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James K. Stoller, MD and Brian Mandell, MD

Alpha-1 Antitrypsin Deficiency

In this podcast featuring the Cleveland Clinic Journal of Medicine commentary, “Alpha-1 antitrypsin deficiency: A persistently underrecognized condition,” author James K. Stoller, MD, MS, Cleveland Clinic, joins moderator and Cleveland Clinic Journal of Medicine Editor-in-Chief Brian Mandell, MD, PhD. The podcast discusses the underrecognized nature of alpha-1 antitrypsin deficiency, causing harm, and reviews both established guideline-based and emerging AI-supported strategies to improve its detection.

Transcript

Release Date: 10/15/26
Expiration Date: 10/14/29

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Estimated Time of Completion: 30 minutes

Podcast Title

Alpha-1 Antitrypsin Deficiency

CME Title

Alpha-1 Antitrypsin Deficiency: A persistently underrecognized condition

CME Description

“Beyond the Pages: CCJM Podcast” takes you in depth into Cleveland Clinic Journal of Medicine articles. Through moderated interviews with the authors and article reviews by experts in the field, clinicians can have an even better understanding of clinical breakthroughs that are changing the practice of medicine and how to practically apply them in patient care.

Learning Objectives

  • Provide physicians with up-to-date, practical clinical information relevant to internal medicine, cardiology, and related fields.
  • Relay clinical breakthroughs that are changing medical practice and advise listeners how to apply them in daily patient care.

Target Audience

The education is designed for all clinicians.

Accreditation

In support of improving patient care, Cleveland Clinic Center for Continuing Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

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American Medical Association (AMA)

Cleveland Clinic Center for Continuing Education designates this enduring activity for a maximum of 0.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.

Activity Director and Faculty

Activity Directors

Anthony Fernandez, MD, PhD
Director, Medical and Inpatient Dermatology
W.D. Steck Chair of Clinical Dermatology
Co-Director, Center for Continuing Education
Cleveland Clinic, Cleveland, OH

Steven Kawczak, PhD, CHCP, FACEHP
Assistant Professor of Medicine, Cleveland Clinic Lerner College of Medicine of CWRU
Co-Director, Center for Continuing Education
Director, Center for International Medical Education
Staff, Center for Educational Resources
Education Institute
Cleveland Clinic, Cleveland, OH

Moderator

Brian Mandell, MD, PhD
Editor-in-Chief, Cleveland Clinic Journal of Medicine
Cleveland Clinic, Cleveland, OH

Faculty

James K. Stoller, MD, MS
Chief, Education, Cleveland Clinic, Cleveland, OH
Professor and Senior Associate Dean, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

Faculty Disclosure

In accordance with the Standards for Integrity and Independence issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Center for Continuing Education mitigates all relevant conflicts of interest to ensure CME activities are free of commercial bias. All relevant financial relationships have been mitigated.

The following faculty have indicated that they may have a relationship, which in the context of their presentation(s), could be perceived as a potential conflict of interest:

Faculty
Anthony Fernandez, MD, PhD
Company
Abbvie Pharmaceuticals
Relationship
Consulting, Teaching and Speaking (Ended: 07/01/2025), Advisor or review panel participant
Company
Amgen
Relationship
Teaching and Speaking
Company
Biogen Inc.
Relationship
Consulting
Company
Boehringer Ingelheim, UCB, Inc.
Relationship
Consulting (Ended: 07/01/2025), Research
Company
Bristol-Myers Squibb Co.
Relationship
Consulting (Ended: 07/01/2025), Teaching and Speaking (Ended: 07/01/2025)
Company
Castle Biosciences
Relationship
Research (Ended: 08/01/2025)
Company
EMD Serono, Inc.
Relationship
Consulting
Company
Galderma
Relationship
Consulting, Teaching and Speaking
Company
Kyowa Kirin
Relationship
Teaching and Speaking (Ended: 07/01/2025)
Company
Mallinckrodt Inc.
Relationship
Consulting, Teaching and Speaking
Company
Novartis
Relationship
Consulting (Ended: 08/01/2024), Teaching and Speaking (Ended: 08/01/2024)
Company
Pfizer, Inc.
Relationship
Research, Awarded a grant to fund a medical dermatology fellowship position
Company
Priovant Therapeutics
Relationship
Research
Company
UCB, Inc.
Relationship
Consulting (Ended: 07/01/2025)
Faculty
Brian Mandell, MD, PhD
Company
Amgen
Relationship
Consulting, Teaching and Speaking
Company
Arthrosi Pharma
Relationship
Teaching, Speaking and Research. Advisor or review panel participant
Company
Horizon Pharma
Relationship
Consulting (Ended: 12/31/2024)
Company
SOBI
Relationship
Consulting
Company
Wave Therapeutics
Relationship
Data monitoring safety board - phase 1/2 clinical development
Faculty
James K. Stoller, MD, MS
Company
CSL Behring
Relationship
Consulting, Teaching and Speaking
Company
Genzyme/Sanofi
Relationship
Consulting
Company
Gondolabio
Relationship
Consulting
Company
Grifols
Relationship
Consulting, Teaching and Speaking
Company
InhibRx
Relationship
Consulting (Ended: 07/01/2024)
Company
Korro
Relationship
Consulting (Ended: 06/30/2025)
Company
Lupin Pharmaceuticals
Relationship
Consulting
Company
Takeda
Relationship
Consulting and Research
Company
Uptodate
Relationship
Consulting

All other individuals have indicated no relationship which, in the context of their involvement, could be perceived as a potential conflict of interest.

This CME activity was produced by The Cleveland Clinic Foundation Center for Continuing Education.

CME Disclaimer

The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation be liable for any decision made or action taken in reliance upon the information provided through this CME activity.

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Log into myCME and begin the activity evaluation and print your certificate. If you need assistance, contact the CME office at myCME@ccf.org

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