Hemispherectomy

Overview

What is a hemispherectomy?

A hemispherectomy is where half of your child’s brain is either totally or partly removed or disconnected from the rest of the brain. It is a rare surgical procedure done for epilepsy not responsive to medications. It is typically done in children and occasionally in adults. In these patients, the whole hemisphere is abnormal and responsible for causing seizures.

The “hemi” part of “hemispherectomy” means “half” and refers to the cerebral (brain) hemisphere – half of your brain.

What patients are appropriate for a hemispherectomy? What kinds of conditions can be treated with a hemispherectomy?

Your child might need a hemispherectomy if they have these symptoms:

  • Seizures (epilepsy), not controlled with medication.
  • Weakness on one side of their body. Also, they can’t use their hand as well and they might lose their peripheral vision.
  • Abnormal finding on brain MRI that usually affects one side of the brain.
  • Developmental delay because of seizures.

The symptoms listed above are associated with the following conditions and diseases:

Your child might have started having seizures and weakness early in life. Once your healthcare provider suspects drug-resistant epilepsy, you should be referred to a center that specializes in children with seizures.

What are the types of hemispherectomies?

There are two types of hemispherectomies: anatomic and functional (disconnective).

  • Functional (disconnective): The functional technique involves removing a smaller area of the brain and disconnecting the side from the rest of the brain. It has less risk for complications. Hemispherotomy is a term used when the tissue removed is small.
  • Anatomic: Anatomic hemispherectomies are usually performed on children who have persistent seizures despite the “functional/ disconnective” hemispherectomy. This type of hemispherectomy is where the frontal, parietal, temporal and occipital lobes of the brain are removed. This procedure has higher risk for complications – there can be extra blood loss and fluid buildup.

The two types have fairly equal success. However, when a functional hemispherectomy does not lead to seizure freedom, redoing as anatomic hemispherectomy may lead to seizure freedom in a third of patients.

Is a hemispherectomy inpatient or outpatient?

Inpatient. Your child will have to spend time in the hospital.

Figure 1: Right Anatomic Hemispherectomy

A. Coronal MRI at level of anterior frontal lobe.

B. Coronal MRI at level of brainstem.

C. Sagittal MRI demonstrating removal of right hemisphere.

Figure 2: Left Functional Hemispherectomy

A. Coronal MRI demonstrating central resection and temporal lobectomy.

B. Sagittal MRI demonstrating corpus callosotomy and fronto-basal disconnection.

Risks / Benefits

How effective is hemispherectomy?

Two-thirds of children who undergo hemispherectomy are completely seizure-free and another 15-20% have a substantial reduction of seizures. If a child has persistent seizures after an initial procedure, they should be carefully evaluated to see if they could benefit from a repeat surgery.

What complications are possible following a hemispherectomy?

Most children have excellent long-term results following a hemispherectomy. Occasionally, however, some complications may occur:

  • Early complications, which occur either while the operation is happening or immediately after it, include blood loss, electrolyte changes, hypothermia and aseptic meningitis.
  • Fluid buildup in brain, also called hydrocephalus - in less than 5% with disconnective / functional hemispherectomy, and slightly higher risk with anatomic hemispherectomy.

Recovery and Outlook

How long is the hospital stay after hemispherectomy?

After epilepsy surgery, your child will spend two to three days in the pediatric intensive care unit (PICU) for close monitoring. Antiepileptic medications will be continued.

What tests may be performed in the hospital after hemispherectomy?

A brain CT or MRI may be performed on the first morning after the operation to assess your child’s brain. Once the surgical drains are removed, your child will be transferred to a regular pediatric nursing floor. PT, OT and speech therapy will be consulted based on the child’s needs. An average hospital stay slightly varies between patients and usually ranges from five to seven days. Length of stay decisions are made by the surgical team and are based on your child’s condition and recovery.

What happens after being discharged from hemispherectomy?

Upon discharge, rehabilitation services are often required to enhance recovery from hemispherectomy. Your child may be transferred to a rehab facility for intensive physical, occupational and speech therapy. This is usually followed by home or outpatient services. Outpatient therapy can be provided through hospitals and free-standing facilities and schools. Check with your individual school system to see if this is a service provided.

Last reviewed by a Cleveland Clinic medical professional on 12/14/2020.

References

  • Brain Injury Association of America. . Accessed 12/13/2020.Functions of the Brain (https://www.biausa.org/brain-injury/about-brain-injury/basics/function-of-the-brain)
  • National Organization of Rare Disorders. . Accessed 12/13/2020. Hemimegalencephaly (https://rarediseases.org/rare-diseases/hemimegalencephaly/)
  • Children’s Hemiplegia and Stroke Association. . Accessed 12/13/2020.Hemispherectomy (https://chasa.org/medical/hemispherectomy/)
  • Moosa ANV, Gumpta A, Jehi L, et al. Longitudinal seizure outcome and prognostic predictors after hemispherectomy in 170 children. American Academy of Neurology. 2013;80:253-260. Accessed 12/13/2020.

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