OEIS syndrome, or cloacal exstrophy, is a condition that occurs during fetal development. It affects your baby’s urinary, digestive and reproductive systems. It causes the bladder to develop inside out and some organs to push through a hole in the abdomen. It can also affect the genitals and anus. Treatment involves a series of surgeries.
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OEIS syndrome (pronounced “kloh-EY-kel” “EK-struh-fee”) is a rare congenital condition (birth defect) that affects how the lower abdominal wall, intestines and urinary bladder form during fetal development. This results in the bladder and part of the intestines being outside of the body at birth.
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In addition, babies with cloacal exstrophy usually have other associated abnormalities at birth. The abnormalities affect other abdominal organs, the anus/rectum, genital (penis or vagina) formation, the spinal cord and lower limbs.
Other names for OEIS syndrome are OEIS complex and cloacal exstrophy. Healthcare providers sometimes use the “OEIS” names because the condition causes the following conditions:
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OEIS syndrome symptoms are visible at birth and may include:
Healthcare providers don’t know why some babies develop cloacal exstrophy. And there’s no known way to prevent it before or during pregnancy. Something happens during the first trimester of pregnancy that causes the cloacal membrane to tear or break apart.
The cloaca is the area where the male/female reproductive system, digestive system and urinary system come together. The cloacal membrane usually separates the organs in these systems. But if the membrane tears or breaks apart, the fetus’s abdominal wall doesn’t form completely. Organs don’t develop as they should or may connect incorrectly. Some organs poke through an abdominal opening.
Cloacal exstrophy increases the risk of:
Healthcare providers usually diagnose cloacal exstrophy during a prenatal ultrasound. They may also recommend a fetal MRI, which provides more detailed images of fetal organs. These tests may reveal:
After birth, your baby may get other imaging tests to see how severe the condition is and how well their organs work. This information helps your child’s provider develop a treatment plan. These tests may include an MRI, abdominal ultrasound and other tests.
All newborns with OEIS syndrome need staged surgical reconstruction. It’s a series of surgeries that take place over many years. During these surgeries, healthcare providers put your baby’s organs in their proper places and close the abdominal and spinal openings.
Treatments soon after birth may include:
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Treatments during early childhood may include:
Your child will usually need other surgeries on their bladder as they grow.
Your child will likely need multiple surgeries over many years. It can take years because your child needs to grow and develop in between procedures. But improvements in surgical approaches, anesthesia and infant nutrition have helped increase cloacal exstrophy survival rates. Your child will have a team of specialists to help manage their long-term needs.
Your child’s recovery depends on the severity of their cloacal exstrophy and how many procedures they need. You may need special strategies for managing their pee and poop. Their medical team will give you a better idea of what to expect according to your child’s specific situation.
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The goals of treatment are to:
You’ll work closely with your child’s healthcare providers to learn about and manage their care and learn how to prevent infections. As your child grows and develops, their providers may recommend additional procedures.
During your appointments, you may wish to ask the following questions:
OEIS syndrome is a complex condition that can cause many complicated feelings. You might feel scared or helpless. But you’ll have a care team to support you. A team-based approach to your child’s care is very important. The team may include:
It’s important to schedule regular appointments with your child’s providers so they can check on your child’s health and schedule any other necessary treatments. They can also recommend support groups. If you have any questions, reach out to them for help.
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Cloacal exstrophy is a more severe condition that involves more areas of the body. It usually affects the bladder, genitals, spinal cord and bowel.
Bladder exstrophy is typically just one part of cloacal exstrophy. Classic bladder exstrophy only affects the external genitals and bladder. The bladder and genitals are “opened up.” The bladder is outside the body at birth.
Finding out that your child has a congenital condition can cause a flood of emotions. You might feel afraid for your child or second-guess your abilities as a caregiver.
It’s important to remember that if your child has OEIS, you’re not to blame. It’s a condition that appears to happen without any specific cause. Many times, a healthcare provider can diagnose it during an ultrasound and prepare you for what to expect during the rest of your pregnancy and the first years of your child’s life.
With appropriate treatment, most children who have cloacal exstrophy at birth enjoy full lives. But those first years can be challenging. Talk to your child’s providers about any concerns you have and lean on your family and friends for support.
Our fetal surgery program includes leading experts and advanced technology. We perform in utero surgery for tumors, spina bifida and many other birth defects.
Last reviewed on 07/08/2025.
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