Adult Cystic Fibrosis

Lung Function at Cleveland Clinic’s Adult Cystic Fibrosis Clinic

In addition to caring for individuals with CF who require lung transplantation, the Adult CF Program provides patient-centered, multidisciplinary care to adults with earlier stages of CF lung disease. A major focus of the team is a culture of consistent quality improvement. Most patients opted for 1 to 2 of their clinic visits to occur virtually in 2021. As a result, spirometry measurements are a combination of values obtained in the pulmonary function lab and those obtained at home using handheld spirometry devices.

Median FEV₁ Percent Predicted Among Pretransplant Adult Cystic Fibrosis Patients (N = 105)


CF = cystic fibrosis, FEV₁ = forced expiratory volume in 1 second

Source: Cystic Fibrosis Foundation Patient Registry. 2022 Annual Data Report

Spirometry measurements are an important indicator of the lung health of individuals living with CF. Among individuals aged 18 years and older who have not undergone lung transplant and are followed in the CF Foundation patient registry, the median forced expiratory volume in 1 second (FEV₁) in 2022 was 80.2% predicted. At Cleveland Clinic, the median FEV₁ among similar individuals followed in the CF clinic was 84.5%.