Reproductive Endocrinology and Infertility

Reproductive Endocrinology and Infertility

While success rates for in vitro fertilization (IVF) continue to improve over time, patient age remains the strongest predictor of success. Cleveland Clinic’s In Vitro Fertilization Laboratory employs advanced technology for the culture, growth, and assessment of embryos. The EmbryoScope®, a highly sophisticated incubation chamber with time-lapse imaging capacity enables continuous monitoring of embryo growth kinetics. We are the only lab in Ohio that uses these hi-tech time-lapse incubators for culture of all patient embryos. The laboratory’s extensive databases allow tracking and analysis of embryo morphologic features associated with a high probability of resulting in a pregnancy. Algorithms developed using morphokinetic data from time-lapse imaging have been instrumental in enhancing the lab’s ability to select embryos most likely to implant. As a result, our IVF program has successfully shifted to transfer of only a single blastocyst to patients while still maintaining high pregnancy rates even wthout preimplantation genetic testing. Embyro cryopreservation is another area in which the IVF lab excels. Pregnancy rates with transfer of frozen-thawed embryos is equivalent if not higher than that with fresh embryo transfer. The research laboratory associated with our IVF clinic has been instrumental in development of new techniques and the expertise of our embryologists. Recently, the Cleveland Clinic IVF program was ranked #7 in Newsweek’s report on the top fertility clinics in the U.S. We continue to explore application of cutting edge technologies that may benefit our patients. Our newest research venture has been exploring the use of artificial intelligence for embryo selection.

Unless otherwise specified, outcomes reported here reflect care by gynecology staff practicing in Cleveland Clinic facilities in northeast Ohio.