Department Hematology and Medical Oncology
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Treatment & Services

  • Cancer Center
  • Clinical Trials
  • Screening and Testing
View all 3 Treatment & Services +

Specialty in Diseases & Conditions

  • Cancer
  • Chemotherapy Related Symptoms
  • Lung Cancer
  • Mesothelioma
  • Rare Cancer and Blood Disease Program
  • Thymic Cancer
  • Thymic Tumors
View all 7 Specialties +


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About Nathan Pennell, MD, PhD

Dr. Pennell is a board certified medical oncologist who joined the staff of the Taussig Cancer Center in 2008. He specializes in the treatment of thoracic malignancies with a focus on lung cancer, and was appointed director of the TCI lung cancer medical oncology program in 2010. He is a professor of medicine at the Cleveland Clinic Lerner College of Medicine.

Dr. Pennell's research interests include clinical trials using novel therapies, with a goal of facilitating the movement of new treatments from the laboratory to the clinic.

He received his Ph.D. in neuroscience in 1998 and his M.D. in 2002 from the University of Florida College of Medicine in Gainesville, FL.

Dr. Pennell completed his internal medicine residency in 2005 at Brigham and Women's Hospital in Boston, MA. His medical oncology fellowship training was completed in 2007 at the Dana Farber Cancer Institute. 

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Dana-Farber Cancer Institute Harvard Medical School
Medical Oncology
Boston, MA USA

Residency - Brigham & Women's Hospital
Internal Medicine
Boston, MA USA

Internship - Brigham & Women's Hospital
Internal Medicine
Boston, MA USA

Medical Education - University of Florida College of Medicine
Gainesville, FL USA

Medical Education - University of Florida College of Medicine
Gainesville, FL USA

Undergraduate - University of North Carolina Health Care System
Chapel Hill, NC USA

Additional Training

  • Program in Clinical Effectiveness, Harvard School of Public Health, 2006

Professional Highlights


  • Internal Medicine - Medical Oncology

Specialty Interests

Lung cancer, mesothelioma, thyroid cancer, clinical trials, cancer, chemotherapy related symptoms

Awards & Honors

Innovations & Patents


  • American Society of Clinical Oncology
  • International Association for the Study of Lung Cancer
Research & Publications

Research & Publications

See publications for Nathan Pennell, MD, PhD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 4/22/2020, Dr. Pennell has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Pennell receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Merck & Co., Inc.
  • AstraZeneca
  • Research to Practice
  • Cota, Inc.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

108 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 5
Courtesy, Respect & Concern 5
Patient Rating of Doctor 4.9

17 Patient Comments

Reviewed on Jul 16, 2020

Dr. Pennell is always very thorough and caring

Reviewed on Jun 19, 2020

I greatly appreciate Dr. Pennell and the treatment I have received from him and his staff.

Reviewed on Jun 18, 2020

Dr. Pennell always explains what he is recommending and why. He carefully listens to your iinput and and will make recommendations. He is quick to look at anything that he feels may be suspicious. I have never had a Doctor that has demonstrated this amount of care. i will always be grateful to him.

Reviewed on Jun 11, 2020

*Dr. Pennell is wonderful & excellent dr. as well as a great personal manner.

Reviewed on Jun 4, 2020

my experience with Dr. Pennell has always been good

Reviewed on May 5, 2020

we have a lot of respect for Dr.Pennell very patient and helpful we are and will be forever grateful

Reviewed on Mar 13, 2020

Dr. Pennell was prepared for my appointment and was excellent at answering my questions. Feel much more confident in the care I'm receiving at CC knowing Dr. Pennell is coordinating my care.

Reviewed on Mar 10, 2020

I have complete trust in Dr Pennell and his care and treatment of my disease.

Reviewed on Mar 3, 2020

Dr Pennell is an exceptional doctor. He saved my life. My wife and I will always hold him in high regards.

Reviewed on Mar 3, 2020

Dr Pennell brought to my attention and referred me to a Vascular Doctor due to finding two aneurysms. They are small enough now that they do not need an operation. I am very greatfull he found them on my scan.

Reviewed on Feb 27, 2020

Dr. Pennell is good about answering my questions. His positive yet realistic approach is appreciated.

Reviewed on Dec 31, 2019

Dr. Pennell is always very professional, polite and listens to my concerns. And if I need any thing to call and leave a message.

Reviewed on Dec 3, 2019

Dr Pennell is very knowledgeable in his practice of an oncologist. he has a good bed side manner and is thorough in his diagnosis

Reviewed on Nov 22, 2019

The Dr was very thorough.

Reviewed on Oct 8, 2019

Very good experience. *Dr. LeGrand is the best. We appreciate her expertise. Excellent!!

Reviewed on Sep 19, 2019

Dr Pennell is an excellent communicator.

Reviewed on Sep 17, 2019

The Dr was very caring and professional. He answered all my concerns.

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