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Department Hematology and Medical Oncology
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Treatment & Services

  • Cancer Center
  • Clinical Trials
  • Health Screening and Testing
View all 3 Treatment & Services +

Specialty in Diseases & Conditions

  • Cancer
  • Chemotherapy Related Symptoms
  • Lung Cancer
  • Mesothelioma
  • Rare Cancer and Blood Disease Program
  • Thymic Cancer
  • Thymic Tumors
View all 7 Specialties +


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About Nathan Pennell, MD, PhD

Dr. Pennell is a board certified medical oncologist who joined the staff of the Taussig Cancer Center in 2008. He specializes in the treatment of thoracic malignancies with a focus on lung cancer, and was appointed director of the TCI lung cancer medical oncology program in 2010. He is a professor of medicine at the Cleveland Clinic Lerner College of Medicine.

Dr. Pennell's research interests include clinical trials using novel therapies, with a goal of facilitating the movement of new treatments from the laboratory to the clinic.

He received his Ph.D. in neuroscience in 1998 and his M.D. in 2002 from the University of Florida College of Medicine in Gainesville, FL.

Dr. Pennell completed his internal medicine residency in 2005 at Brigham and Women's Hospital in Boston, MA. His medical oncology fellowship training was completed in 2007 at the Dana Farber Cancer Institute. 

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Dana-Farber Cancer Institute Harvard Medical School
Medical Oncology
Boston, MA

Residency - Brigham & Women's Hospital
Internal Medicine
Boston, MA

Internship - Brigham & Women's Hospital
Internal Medicine
Boston, MA

Medical Education - University of Florida College of Medicine
Gainesville, FL

Medical Education - University of Florida College of Medicine
Gainesville, FL

Undergraduate - University of North Carolina Health Care System
Chapel Hill, NC

Additional Training

  • Program in Clinical Effectiveness, Harvard School of Public Health, 2006

Professional Highlights


  • Internal Medicine - Medical Oncology

Specialty Interests

Lung cancer, mesothelioma, thyroid cancer, clinical trials, cancer, chemotherapy related symptoms

Awards & Honors

Innovations & Patents


  • American Society of Clinical Oncology
  • International Association for the Study of Lung Cancer
Research & Publications

Research & Publications

See publications for Nathan Pennell, MD, PhD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 4/3/2024, Dr. Pennell has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Pennell receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • Janssen Pharmaceuticals, Inc.
  • Iovance Biotherapeutics, Inc.
  • Vial
  • Takeda Pharmaceuticals North America, Inc.
  • ResistanceBio, Inc.
  • Anheart Pharmaceuticals, Inc.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

128 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 4.8
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

22 Patient Comments

Reviewed on May 17, 2024

Dr. Pennell is a very kind and caring doctor. I couldn't ask for better.

Reviewed on May 16, 2024

An outstanding physician

Reviewed on May 7, 2024

Dr. Pennell is a caring, knowledgeable, thoughtful physician.

Reviewed on Apr 25, 2024

Dr Pennell entered room without computer barrier as he clearly had my entire case in mind! First asked me about how I was referred to him then secondly what I understood about my cancer. Being a retired physician, I was frankly able to explain to his satisfaction. After a cursory physical exam, he began explaining to me my options as he sees it. He was very honest and forthright in his explanations

Reviewed on Apr 9, 2024

Dr. Pennell patiently answered all my questions very thoroughly

Reviewed on Apr 9, 2024

I choose to keep in touch with Dr. Pennelll for my second opinions. The staff were very kind and accommodating.

Reviewed on Mar 19, 2024

Dr. Purnell is the Best!

Reviewed on Jan 12, 2024

Dr. Videtic is probably one of the most caring, competent and friendly physicians that I have ever met!

Reviewed on Jan 11, 2024

Dr. Pennell very nice person

Reviewed on Jan 2, 2024

Excellent caring doctor

Reviewed on Dec 15, 2023

When you're Dr walks in and he is smiling from ear to ear you know it's going to be a good thing

Reviewed on Dec 14, 2023

Have been seeing Dr. Pennell for more than six years. He always show care and concern for me. He listens and always answers my questions to my satisfaction. I have recommended him to others.

Reviewed on Dec 8, 2023

Exceptional visit with Dr. Pennell providing complete explanations of current condition, test results and future plans that satisfied all my question and concerns.

Reviewed on Nov 16, 2023

My doctor was very nice & considerate!

Reviewed on Nov 10, 2023

Dr Pennell is the best oncologist I've ever met. He's kind, soft spoken, always smiling, listens, gives advice and answers all of our questions whenever they arise I'm so glad he is my Dr and is helping give me a few extra years on this earth. That is priceless.

Reviewed on Aug 17, 2023

Dr. Pennell is always pleasant and easy to talk to. Always answers any questions or concerns.

Reviewed on Aug 10, 2023

Dr. Pennell is very very competent, caring and cordial.

Reviewed on Jul 28, 2023

We were very impressed and uplifted by the Dr.

Reviewed on Jul 7, 2023

I am so thankful I was able to meet w Dr Pennell. He was very caring, patient, and thorough. I couldn't have asked for a better experience

Reviewed on Jul 6, 2023

Dr. Nathan Pennell is very nice & considerate!!

Reviewed on Jun 15, 2023

The very Best Dr...so thankful to have him!!!!!

Reviewed on Jun 8, 2023

Very good doctor very friendly and very thorough and his nurse Nicole was very good too and she is also very friendly

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