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E. Murat Tuzcu, MD

E. Murat Tuzcu, MD
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Department Cardiovascular Medicine
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Treatment & Services

  • Abnormal Stress Test
  • Angiography
  • Angioplasty
  • Balloon Mitral Valvotomy
  • Cardiovascular Medicine Department
  • Coronary Balloon Angioplasty (PTCA)
  • Coronary Intervention
  • Drug Eluting Stenting
  • Endovascular Patent Foramen Ovale (PFO) Closure
  • Fractional Flow Reserve (FFR) Determination
  • Heart Valve Disease - Percutaneous Interventions
  • Hypertrophic Cardiomyopathy Center
  • Intervention Section
  • Intra-Aortic Balloon Pumping
  • Percutaneous Closure of Paravalve Leak
  • Percutaneous Valve Treatment
  • Percutaneous VSD closure
  • Rotational Atherectomy
  • Valve Surgery
  • Virtual Histology
View all 20 Treatment & Services +

Specialty in Diseases & Conditions

  • Angina
  • Aortic Stenosis
  • Atrial Septal Defects
  • Coronary Artery Disease
  • Heart Attack
  • Hypertrophic Cardiomyopathy
  • Ischemic Cardiomyopathy
  • Patent Foramen Ovale
  • Restenosis
View all 9 Specialties +


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About E. Murat Tuzcu, MD

Murat Tuzcu, M.D. is a Professor of Medicine, Vice Chairman of the Robert and Suzanne Tomsich Department of Cardiovascular Medicine, and a Staff Physician in the Section of Interventional Cardiology in the Sydell and Arnold Heart, Vascular & Thoracic Institute. 

Dr. Tuzcu's clinical interests cover a wide range of interventional cardiology patients.  In addition to percutaneous treatment of coronary artery disease, his expertise includes catheter-based treatment of valvular heart disease (Transcatheter aortic valve replacement - TAVR), and adult congenital heart defects.  He is an internationally recognized expert in the emerging field of percutaneous valve repair and replacement.  Patients from all over the United States and around the world seek his expertise.

Dr. Tuzcu's current research interests focus on the investigation of catheter-based treatments for valvular heart disease.  He holds several patents involving catheter design.  Another long term research interest involves the use of various imaging modalities to elucidate the development and progress of atherosclerosis.  He has made seminal contributions to the understanding of transplant coronary artery disease and subclinical atherosclerosis using intravascular ultrasound imaging.  He had and continues to have leadership roles in landmark studies in his areas of his research interests.

Dr. Tuzcu received his medical degree from Istanbul Medical Faculty in Turkey, where he completed his internship and residency in Internal Medicine.  He was then awarded fellowships by Cleveland Clinic in Cardiovascular Disease and Interventional Cardiology.  He was a special clinical and research fellow, then a junior faculty at the Massachusetts General Hospital and Harvard Medical School in Boston.  He was appointed to Cleveland Clinic as a staff in 1992.  He is certified as a Diplomate of the American Board of Internal Medicine in Internal Medicine, Cardiovascular Diseases and Interventional Cardiology.

Dr. Tuzcu is heavily involved in the training of young cardiologist.  Through work in the International Center, Dr. Tuzcu is also involved in medical education of doctors from all over the world.  He has held several academic appointments including Instructor in medicine and Research at Harvard Medical School, Assistant Professor of Medicine at the University of Pittsburgh and Professor of Medicine at Ohio State University.  Currently, he is a Professor of Medicine in the Lerner College of Medicine at Case Western Reserve University.

He has authored or co-authored more than 200 peer-reviewed publications.  Dr. Tuzcu has directed or co-directed many national and international symposiums and professional conferences worldwide, and has been an invited lecturer to many others.  He was the Chairman of the Scientific Program Committee of the 56th Annual Scientific Sessions in 2007.  He is currently on the editorial board of several academic journals.

Dr. Tuzcu is a Fellow in the American College of Cardiology, American Heart Association, Society for Cardiac angiography and Interventions, the American College of Physicians, and a member of the Turkish Society of Cardiology.  Dr. Tuzcu was voted into the recent listing of "Best Physicians in America," and is listed in the National Registry of Who's Who.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Massachusetts General Hospital
Cardiology and Cardiology Research
Boston, MA

Fellowship - Cleveland Clinic
Interventional Cardiology
Cleveland, OH

Fellowship - Cleveland Clinic
Cleveland, OH

Residency - Istanbul University, Istanbul Medical School
Internal Medicine
Capa, Istanbul,

Internship - Istanbul University, Istanbul Medical School
Capa, Istanbul,

Medical Education - Istanbul University, Istanbul Medical School
Capa, Istanbul,

Professional Highlights

  • Chair, American College of Cardiology Annual Scientific Sessions 2007


  • Internal Medicine - Cardiovascular Disease

Specialty Interests

Coronary artery disease, aortic stenosis, stent restenosis, endovascular patent foramen ovale closure, intravascular ultrasound, coronary intervention, percutaneous closure of paravalve leak, valvuloplasty, heart valve disease - percutaneous interventions

Awards & Honors

  • Best Doctors in America
  • Top Doctors in America

Innovations & Patents

  • Pioneer in catheter-based treatment of heart valve disease
  • Among the leaders in the newly emerging technique of nonsurgical valve replacement and repair


  • American College of Cardiology
  • American Heart Association
  • Society for Cardiovascular Angiography and Interventions
  • American College of Physicians
Research & Publications

Research & Publications

See publications for E. Murat Tuzcu, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 10/2/2020, Dr. Tuzcu has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

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