Emergency icon Important Updates

Lilyana Angelov, MD

Lilyana Angelov, MD
  • Watch Video
  • No ratings
  • 0 Patient Satisfaction Ratings
  • 0 Patient Comments
Title Director, Gamma Knife Center
Department Brain Tumor and Neuro-Oncology Center
Primary Location Cleveland Clinic Main Campus
Type of Doctor Both Adults and Children & Adolescents
Languages Bulgarian, English, French, Macedonian
Surgeon Yes
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Treatment & Services

  • Brain Biopsy
  • Brain Tumor Diagnosis
  • Brain Tumor Management
  • Brain Tumor Surgery
  • Cancer Center
  • Clinical Trials
  • Cranial Radiosurgery
  • Craniotomy for Brain Tumor
  • Gamma Knife Radiosurgery
  • Intra-Arterial Chemotherapy with Blood-Brain-Barrier Disruption
  • Kyphoplasty
  • Lumbar Puncture (Spinal Tap)
  • Minimally Invasive Surgery
  • Neurological Surgery
  • Neuro-Oncology
  • Neurosurgery
  • Novalis Radiosurgery/Radiotherapy
  • Spine Radiosurgery
  • Stereotactic Brain Biopsy
  • Stereotactic Radiosurgery
View all 20 Treatment & Services +

Specialty in Diseases & Conditions

  • Adult Brain Tumors
  • Anaplastic Astrocytomas
  • Anaplastic Oligodendrogliomas
  • Astrocytoma
  • Benign Brain Tumors
  • Benign Tumors of the Spinal Cord
  • Brain Cancer
  • Brain Lymphoma
  • Brain Metastases
  • Ependymomas
  • Glioblastoma Multiforme
  • Malignant Gliomas
  • Malignant Tumors of the Spinal Cord
  • Meningioma
  • Metastatic Cancer
  • Oligodendroglioma
  • Primary Central Nervous System (CNS) Lymphomas
  • Sarcomas of the Brain or Head
  • Schwannoma
  • Spinal Cancer
  • Spine Pain
  • Spine Tumors
View all 22 Specialties +


Is Cleveland Clinic Part of Your Insurance?

Review a list of accepted insurance plans for our Northeast Ohio locations or learn more about purchasing a contracted managed care plan.

View All Plans

About Lilyana Angelov, MD

Lilyana Angelov, MD, is a Neurosurgeon who is board-certified in both the United States and Canada. She is the Director of Cleveland Clinic’s Gamma Knife Center, Director of the Neurosurgical Oncology and Radiosurgery Fellowship Programs, Head, Section of Spinal Tumors and Clinical Professor of Neurological Surgery, Cleveland Clinic Lerner College of Medicine. Outside of the Cleveland Clinic, she is Vice President of the World Spinal Column Society and serves on the AANS/CNS Section on Tumors Executive Committee.

Dr. Angelov has a multifaceted clinical practice and research interests which focus on the surgical treatment of patients with brain tumors such as metastatic brain tumors, primary (malignant and benign) brain tumors as well as cares for patients with malignant and benign spine tumors utilizing spine radiosurgery. Indeed, an important focus of her work is the development of a spine radiosurgery program that she founded at the Cleveland Clinic in 2006. This was the first clinical program of its kind in Ohio and among one of the earliest such programs in all of the United States and this very active clinical program that is now recognized globally.

Dr. Angelov serves as a Course Director for the Gamma Knife CME training course as well the Annual International Symposium on Stereotactic Body Radiation Therapy and Stereotactic Radiosurgery and coordinates the three yearly Neurosurgery Visiting Professorships. She also directly mentors numerous fellows, residents and medical students and has over 100 peer-reviewed publications.

Dr. Angelov received her Medical degree and completed her Neurosurgical Residency at the University of Toronto in Ontario, Canada. Subsequently, she completed a fellowship at St. Michael’s Hospital (Toronto, Canada) in Neurosurgical Trauma as well as a Neurosurgical Oncology fellowship at the Cleveland Clinic. She has been a member of the Cleveland Clinic Staff since 2003.

The following articles related to Dr. Angelov may be of interest to patients:

Management of Lung Cancer Brain Metastases: An Update

Case Study Spotlights Pioneering Use of Staged Radiosurgery for Previously Untreatable Brain Metastases 

Pioneering Staged Gamma Knife Therapy for Large Brain Metastases

2-Staged Stereotactic Radiosurgery for Large Brain Metastases: More Support from Largest Series Yet 

Gamma Knife for Brain Tumors: Latest Developments and What’s on the Horizon

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Cleveland, OH USA

Fellowship - Saint Michael's Hospital
Toronto, ON Canada

Residency - University of Toronto
Toronto, ON Canada

Internship - Saint Michael's Hospital
Internal Medicine
Toronto, ON Canada

Medical Education - University of Toronto Faculty of Medicine

Undergraduate - University of Toronto
Toronto, ON Canada


  • Neurological Surgery
  • Neurological Surgery

Specialty Interests

CNS metastatic disease, Gamma Knife Radiosurgery, intraarterial chemotherapy with blood-brain-barrier disruption, neuro-oncology, spine radiosurgery, benign and malignant tumors of the brain and spinal cord, benign brain tumors (meningiomas, schwannomas), Brain Metastases, brain tumors, gamma knife, gamma knife and radiosurgery, molecular biology of brain tumors clinical and translational trials, Spinal Radiosurgery, stereotactic surgery, tumors of the brain and spine

Awards & Honors

  • 2008 Robert Ginsberg Surgical Oncology Award, Radiation Therapy Oncology Group (RTOG)
  • "Top Docs in America," Cleveland Magazine, 2007
  • Outstanding Presentation Award at Neurosurgery Science Management Meeting, New Orleans, La.; October 2000
  • 1999 McKenzie Award for Basic Neuroscience Research awarded by the Canadian Congress of Neurological Sciences; June 1999
  • Thomas P. Morley Neurosurgery First Prize; February 1999
  •  American Association of Neurological Surgeons Research Fellowship, 2 years; July 1997
  •  National Cancer Institute (NCI) Canada Post-MD Research Fellowship, 3 years; July 1997

Innovations & Patents

  • Spine Radiosurgery at Cleveland Clinic
Research & Publications

Research & Publications

See publications for Lilyana Angelov, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 7/17/2023, Dr. Angelov has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Back to Top