We have an ongoing investigator initiated, randomized controlled trial based on an innovative clinical approach leveraging a group-based dynamic, i.e., the sleep apnea management group clinic effect on positive airway pressure (PAP) adherence, PAP barriers, and patient reported outcomes. In this trial the group approach outcomes are compared to the usual care outcomes.
Another research focus has been to characterize the effect of Positive Airway Pressure (PAP) therapy for Obstructive Sleep Apnea (OSA) on patient reported outcomes (PROs). We have examined changes in quality of life measures, depressive symptoms, drowsy driving, and restless legs syndrome symptoms correlated with the use of PAP therapy and PAP therapy adherence in patients with OSA. Further, we examined the impact of age, gender, and socioeconomic status on these measures.
A final area of focus examines the impact of sleep apnea therapies on PROs in hypertensive and resistant hypertensive individuals.
Cleveland Clinic Neurological Institute (NI) Center of Research Outcomes and Evaluation Scholar, 2016-2017 (Harneet Walia)
Association of severe obstructive sleep apnea and elevated blood pressure despite antihypertensive medication use J Clin Sleep Med. 2014 Aug 15;10(8):835-43, PMCID: PMC4106395. Walia HK, Li H, Rueschman M, Bhatt DL, Patel SR, Quan SF, Gottlieb DJ, Punjabi NM, Redline S, Mehra R.
Longitudinal Effect of Continuous Positive Airway Pressure on Blood Pressure in Resistant Hypertension and Hypertension in a Large Clinic-Based Cohort Chest. 2016 Mar; 149(3):747-55.Walia HK, Griffith SD, Thomas G, Bravo EL, Moul DE, Foldvary-Schaefer, Mehra R.
Impact of Sleep Disordered Breathing Treatment on Subjective Patient Reported Outcomes in a Large Hypertension Clinic-Based Cohort Enriched with Resistant Hypertension, Journal of Clinical Sleep Medicine, 2016 Aug 22. Walia HK, Griffith SD, Moul DE, Foldvary-Schaefer, Mehra R.
Impact of Sleep Disordered Breathing treatment on Quality measures in a large clinic based cohort. J Clin Sleep Med 2017 October 4, PMID 28992832. Walia HK, Thompson N, Foldvary-Schaefer N, Katzan I, Mehra R.
Depression Score Changes in Response to Sleep Disordered Breathing Treatment with Continuous Positive Airway Pressure in a Large Clinic-Based Cohort. Sleep Breath. 2018 Jan 29. doi: 10.1007/s11325-018-1626-6.Relia S, Thompson N, Katzan I, Foldvary-Schaefer N, Mehra R, Walia HK.
Continuous Positive Airway Pressure adherence predictors in a randomized controlled trial enriched with women and minorities. Chest. 2018 Apr 20. May AM, Gharibeh T, Hurley A, Walia HK, Strohl KP, Mehra R.
Effect of Positive Airway Pressure Therapy on Drowsy Driving in a Large Clinic-Based Obstructive Sleep Apnea Cohort.Walia HK, Thompson NR, Pascoe M, Faisal M, Moul DE, Katzan I, Mehra R, Foldvary-Schaefer N., J Clin Sleep Med. 2019 Oct 7.
Upper Airway Stimulation vs Positive Airway Pressure Impact on BP and Sleepiness Symptoms in OSA. Walia HK, Thompson NR, Strohl KP, Faulx MD, Waters T, Kominsky A, Foldvary-Schaefer N, Mehra R., Chest. 2019 Jul 9.
Patient-reported outcomes in older adults with obstructive sleep apnea treated with continuous positive airway pressure therapy. Pallanch J Li Y, Bena J, Wang L, Foldvary-Schaefer N., J Clin Sleep Med. 2018; 14(2):215–222.