The overall objective of the Clinical and Translational Outcomes Research team (CTOR) is to optimize the treatment outcomes of patients with epilepsy using today’s therapies, while striving to develop safer and more successful treatments for tomorrow. We characterize the outcomes of epilepsy treatment, while understanding drivers of treatment response, in order to: 1) guide physician-patient decision making, 2) facilitate informed patient choice, and 3) define the mechanisms of surgical failure and drug-resistance in order to develop better therapies. We achieve these goals through a multi-disciplinary team of investigators and collaborators including specialists in outcome research, predictive modeling, neuropsychology, electrophysiology, neuroradiology, pathology, and genetics. Our team capitalizes on the collective expertise of its members to advance its multi-pronged mission. The deep-rooted tradition of Cleveland Clinic’s Epilepsy Center as a leader in epilepsy surgery, allowed us to build the most comprehensive epilepsy surgery outcomes database in the United States, and to advance innovative hypotheses for the mechanisms of post-operative seizure recurrence. We seamlessly incorporate our clinical and translational research efforts in routine clinical care. Examples of this integration include a system to collect health status measures (validated questionnaires evaluating quality of life, seizure severity, and psychosocial function) at every outpatient visit, and a biobank to collect surgical tissue for research. In summary, our goal is to understand how epilepsy treatments work so we can make them better.
Lara Jehi, MD
- Impact of generalized tonic-clonic seizures in patients with drug-resistant epilepsy. Research grant by Eisai, Inc. PI Jehi.
- Abnormal Interleukin 1-B and Inflammasome Activation as a Mechanism of Seizure Recurrencey After Resective Epilepsy Surgery. R21 NS099734. PI Jehi.
- A Nomogram to predict seizure outcomes after resective epilepsy surgery. R01 NS097719 (P.I Jehi).
- Clinical and Translational Science Collaborative of Cleveland. NIH/NCATS UL1TR000439-06. (P.I. Konstan).
Preliminary report: Late seizure recurrence years after epilepsy surgery may be associated with alterations in brain tissue transcriptome. L, Yehia L, Peterson C, Niazi F, Busch R, Prayson R, Ying Z, Bingaman W, Najm I, Eng C. Epilepsia Open. 2018 May 17;3(2):299-304. doi: 10.1002/epi4.12119. eCollection 2018 Jun. PubMed PMID: 29881812; PubMed Central PMCID: PMC5983127.
International recommendation for a comprehensive neuropathologic workup of epilepsy surgery brain tissue: A consensus Task Force report from the ILAE Commission on Diagnostic Methods. I, Aronica E, Miyata H, Sarnat HB, Thom M, Roessler K, Rydenhag B, Jehi L, Krsek P, Wiebe S, Spreafico R. Epilepsia. 2016 Mar;57(3):348-58. doi: 10.1111/epi.13319. Epub 2016 Feb 3. PubMed PMID: 26839983.
Development and validation of nomograms to provide individualised predictions of seizure outcomes after epilepsy surgery: a retrospective analysis. L, Yardi R, Chagin K, Tassi L, Russo GL, Worrell G, Hu W, Cendes F, Morita M, Bartolomei F, Chauvel P, Najm I, Gonzalez-Martinez J, Bingaman W, Kattan MW. Lancet Neurol. 2015 Mar;14(3):283-90. doi: 10.1016/S1474-4422(14)70325-4. Epub 2015 Jan 29. PubMed PMID: 25638640.
Nomograms to Predict Naming Decline After Temporal Lobe Surgery in Adults with Epilepsy. Busch R., Hogue O, Kattan M, Hamberger M, Drane D, Hermann B, Kim K, Ferguson L, Bingaman W, Gonzalez-Martinez J, Najm I, and Jehi L. Neurology, accepted August 2018.
Members & Collaborations
- William Bingaman, MD
- Robyn Busch, PhD
- Lara Jehi, MD
- Marcia Morita, MD, PhD
- Deborah Vegh, PhD
- Ann Warbel, RN
Cleveland Clinic Affiliations
- Charis Eng, MD, PhD, Genomic Medicine Institute, Cleveland Clinic
- Stephen Jones, MD, PhD, Diagnostic Radiology, Cleveland Clinic
- Michael Kattan, PhD, Chair of Quantitative Health Sciences
External Relationships & Collaborations
- Gregory Worrell, MD, PhD, Mayo Clinic, Chair, Division of Clinical Neurophysiology, Associate Chair, Neurology Research, Department of Neurology
- Fernando Cendes, MD, PhD, University of Campinas, Head of neuroimaging Laboratory, Bresil
- Ingmar Blumcke, MD, Erlangen University, Director of European Brain Bank