Overview
The overall objective of the Clinical and Translational Outcomes Research team (CTOR) is to optimize the treatment outcomes of patients with epilepsy using today’s therapies, while striving to develop safer and more successful treatments for tomorrow. We characterize the outcomes of epilepsy treatment, while understanding drivers of treatment response, in order to: 1) guide physician-patient decision making, 2) facilitate informed patient choice, and 3) define the mechanisms of surgical failure and drug-resistance in order to develop better therapies. We achieve these goals through a multi-disciplinary team of investigators and collaborators including specialists in outcome research, predictive modeling, neuropsychology, electrophysiology, neuroradiology, pathology, and genetics. Our team capitalizes on the collective expertise of its members to advance its multi-pronged mission. The deep-rooted tradition of Cleveland Clinic’s Epilepsy Center as a leader in epilepsy surgery, allowed us to build the most comprehensive epilepsy surgery outcomes database in the United States, and to advance innovative hypotheses for the mechanisms of post-operative seizure recurrence. We seamlessly incorporate our clinical and translational research efforts in routine clinical care. Examples of this integration include a system to collect health status measures (validated questionnaires evaluating quality of life, seizure severity, and psychosocial function) at every outpatient visit, and a biobank to collect surgical tissue for research. In summary, our goal is to understand how epilepsy treatments work so we can make them better.
Contact Information
Lara Jehi, MD
jehil@ccf.org
Funding Sources
- Impact of generalized tonic-clonic seizures in patients with drug-resistant epilepsy. Research grant by Eisai, Inc. PI Jehi.
- Abnormal Interleukin 1-B and Inflammasome Activation as a Mechanism of Seizure Recurrencey After Resective Epilepsy Surgery. R21 NS099734. PI Jehi.
- A Nomogram to predict seizure outcomes after resective epilepsy surgery. R01 NS097719 (P.I Jehi).
- Clinical and Translational Science Collaborative of Cleveland. NIH/NCATS UL1TR000439-06. (P.I. Konstan).
