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Cleveland Clinic Coordinating Center for Clinical Research is Cleveland Clinic's Academic Research Organization (ARO) providing academic focus and leadership to the design, planning and management of clinical trials. Founded in 1991, our mission is to design and conduct innovative clinical research that enhances scientific knowledge and positively impacts the care of patients. For more than 30 years, we have conducted hundreds of clinical trials investigating new Cardiovascular Disease therapies, Obesity, Lipid and Lp(a) Management, and Valvular Disease Therapies.
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Steven E. Nissen, MD

Partner With Us

The C5Research team is comprised of experienced and dedicated physicians, nurses, technologists and support staff within the Heart, Vascular and Thoracic Institute of Cleveland Clinic providing academic leadership and coordination for trials ranging in size from less than 50 to more than 24,000 patients.

  • We will provide you with real world clinical expertise to deliver integrity and credibility to all aspects of clinical trial conduct.
  • We bring scientific and clinical leadership in cardiovascular disease and other specialties in combination with operational excellence to conduct Phase I-IV multicenter clinical trials.

Cleveland Clinic is nationally ranked and globally recognized as the world leader in cardiovascular care.

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Services & Trials


Learn more about the services we offer including cardiovascular imaging, our clinical events committee, as well as other support services.

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Trial Results

View recently completed clinical trials at Cleveland Clinic, as well as their results.

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Podcast | ACC Late Breaking Science: TACTiC Trial

Dr. Nissen worked with C5Research to investigate if a technology-assisted web application can help consumers appropriately determine if they qualify for a statin drug without a prescription.

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