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Cleveland Clinic Coordinating Center for Clinical Research is Cleveland Clinic's Academic Research Organization (ARO) providing academic focus and leadership to the design, planning and management of clinical trials. Founded in 1991, our mission is to design and conduct innovative clinical research that enhances scientific knowledge and positively impacts the care of patients. For more than 30 years, we have conducted hundreds of clinical trials investigating new Thrombolytic Therapies, Lipid Management Therapies, Valve Replacement Therapies and COVID-19 Treatments.
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Steven E. Nissen, MD

Partner With Us

The C5Research team is comprised of experienced and dedicated physicians, nurses, technologists and support staff within the Heart, Vascular and Thoracic Institute of Cleveland Clinic providing academic leadership and coordination for trials ranging in size from less than 50 to more than 24,000 patients.

  • We will provide you with real world clinical expertise to deliver integrity and credibility to all aspects of clinical trial conduct.
  • We bring scientific and clinical leadership in cardiovascular disease and other specialties in combination with operational excellence to conduct Phase I-IV multicenter clinical trials.

Our expertise in cardiovascular disease is recognized worldwide, as evidenced by U.S. News & World Report naming the Cleveland Clinic’s heart program No. 1 in the nation since 1995 and also as one of the nation's top hospitals in its annual "America's Best Hospitals" survey.

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Services & Trials


Learn more about the services we offer including cardiovascular imaging, our clinical events committee, as well as other support services.

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Trial Results

View recently completed clinical trials at Cleveland Clinic, as well as their results.

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