Deflux® is a gel that urologists can inject into your bladder to treat vesicoureteral reflux (VUR) — pee flowing backwards into your ureters. Healthcare providers most often use it to treat VUR in kids. Deflux creates a bulge in your bladder that works as a valve to allow pee to enter your bladder but not back up into your ureters.
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Deflux® (dextranomer/hyaluronic acid) is an injected gel that treats vesicoureteral reflux, or pee backing up from your bladder in the wrong direction. A urologist injects Deflux during cystoscopy — a minimally invasive bladder procedure — and it forms a bulge that acts like a valve. The valve allows pee to flow correctly into your bladder but prevents it from backing up into your ureters (tubes that drain pee from your kidneys).
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Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy
You might hear Deflux procedures called subureteral transurethral injection (STING) or hydrodistension implantation technique (HIT).
Healthcare providers most commonly use Deflux to treat vesicoureteral reflux (VUR) in kids, but they can also use it to treat adults. Providers also sometimes use Deflux to treat urinary incontinence (leaking pee).
VUR causes pee to back up into your ureters, and sometimes all the way to your kidneys. This can cause frequent urinary tract infections (UTIs), kidney scarring and other complications. Kids can grow out of VUR, though they don’t always. Deflux can prevent urine backflow while you wait to see if the issue resolves on its own. Your own tissue also breaks down and replaces the Deflux implant over time (the implant shouldn’t lose its effectiveness as this happens).
Deflux is made of:
Your body naturally breaks down and safely absorbs the Deflux gel over time.
Your provider will give you instructions on how to prepare for a Deflux injection. They may ask you to:
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Tell your healthcare provider about any medications you take, including supplements.
To implant Deflux, a healthcare provider will:
Placing a Deflux implant usually takes less than 30 minutes. It’s an outpatient procedure, so you won’t need to stay in the hospital afterward.
You (or your child) may be a little drowsy right after the procedure. You should spend the rest of the day at home, resting. Your provider may perform a follow-up voiding cystourethrogram (VCUG) to make sure the procedure was successful.
A Deflux implant can treat VUR for up to 25 years.
Benefits of Deflux compared to other treatments include:
Studies have reported success rates between 70% and 93% for Deflux injections. Keep in mind that each study reports slightly different success rates. Generally, Deflux is more effective in treating mild (lower grade) VUR than severe VUR.
Risks of placing a Deflux implant include:
Sometimes, VUR and UTIs continue despite treatment. You may need additional injections if your symptoms continue after one Deflux treatment.
You may be sore, have pain when you pee or have bladder spasms (cramping or strong urge to go to the bathroom) for a day or two after Deflux procedure. After that, you’ll be able to return to your usual activities.
Your child’s provider will tell you what to expect and when to call them in the days following a Deflux procedure. Your child might:
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These are common reactions and should go away in a day or two. Contact their provider if these symptoms last longer. Encourage your child to drink plenty of water and make sure they’re not holding their pee for more than eight hours at a time.
Call the provider that performed the Deflux procedure if you or your child experiences any of these symptoms:
A note from Cleveland Clinic
Vesicoureteral reflux can cause frequent infections from pee backing up into your ureters. If your child has VUR, you may wonder what the best treatment options are. A urologist may suggest a Deflux injection. Deflux injections are safe and minimally invasive, but their effectiveness can vary. They might not work as well if you or your child has severe VUR. Ask your healthcare provider about the benefits and risks of any procedure. They can tell you what your options are and help you choose the right treatment for your specific situation.
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Last reviewed on 07/08/2024.
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