Hypokalemic periodic paralysis is a rare genetic condition that causes episodes of muscle weakness or paralysis. It links to low potassium levels. Attacks can be scary, but with the right care and lifestyle changes, you can manage symptoms and prevent complications.
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Hypokalemic periodic paralysis (hypoPP) causes sudden episodes (attacks) of extreme muscle weakness or paralysis. These attacks can last for hours or even days. This rare genetic condition can start in childhood, teen years or adulthood. Most people have their first attack before age 35.
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Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy
Hypokalemia means potassium levels in your blood are too low. Potassium is a mineral that helps your muscles work. During attacks, you may have low potassium in your blood.
When an attack happens, it can feel overwhelming. Your body may not move the way you expect, and that can bring fear or frustration. Getting a clear diagnosis can take time. But once you have it, you and your healthcare provider can work on a plan to manage symptoms.
Treatment may not stop every attack, but it can reduce how often they happen and how severe they feel.
There are two main types. Each links to a different gene. These affect how your muscles work:
The main symptom of hypoPP is sudden muscle weakness or paralysis. It usually affects your arm or leg muscles. It also usually affects your legs before your arms and neck.
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You might notice that weakness:
Before an attack, you might also notice:
Between attacks, you usually get your muscle strength back. You may have mild weakness at times, but light exercise might improve it.
Certain things can set off attacks if you have hypoPP. These include:
Your healthcare provider may recommend avoiding these triggers to help lower your risk of attacks.
A genetic change (mutation) causes hypokalemic periodic paralysis. These affect how sodium or calcium channels work. The channels control how your muscles move.
In hypoPP, sodium channels may stay open too long. When this happens, too much sodium flows into muscle cells. It disrupts the normal electrical signals. This keeps your muscles from firing signals the right way.
Calcium channel problems affect how your muscles tighten (flex) and move. When either channel doesn’t work as it should, your skeletal muscles can’t contract properly. This leads to sudden episodes of muscle weakness or paralysis.
Researchers have found several gene variants that cause most hypoPP cases, including:
You inherit these gene changes in an autosomal dominant pattern. This means if just one of your biological parents has the variant, you can develop the condition.
Your risk is higher if someone in your biological family has hypoPP. Most cases happen because of a genetic mutation, so there’s no way to prevent them.
If you or your partner has hypoPP and plan to have biological children, you may want to meet with a genetic counselor. A counselor can explain your risk of passing the condition on and answer your questions.
Rarely, this condition can affect the muscles you use to breathe. But this can be life-threatening and requires immediate medical attention.
In some cases, low potassium during an attack can also cause irregular heart rhythms.
You might develop persistent muscle weakness later in life. It’s more common in your legs and hips because of muscle damage. Some people only have mild weakness. But others may develop severe weakness that limits daily activities or requires a wheelchair.
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A healthcare provider will start by asking about your symptoms and your biological family health history. They’ll offer tests to learn more about the symptoms you have. Testing helps rule out conditions that cause similar symptoms. These could include:
Some providers may also use an exercise test during an EMG to look for muscle changes between attacks.
There’s no cure for hypokalemic periodic paralysis. But treatments can help you manage the condition and lower your risk of complications.
To treat paralysis attacks right away, your healthcare provider may recommend:
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Your provider may also recommend options to prevent future attacks:
Medications vary based on your body’s needs. Your treatment plan may include:
If you have hypokalemic periodic paralysis, you’ll need regular visits with your healthcare provider. They’ll check your symptoms and potassium levels to make sure your treatment plan is working.
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Call your provider right away if:
Managing hypoPP can sometimes feel stressful. If the condition affects your mood or daily life, consider talking with a mental health professional. They can help you cope with the challenges of living with this condition.
The outlook is different for each person. Some people have only a few mild attacks, while others may have more frequent or severe ones. Attacks may be less frequent as you get older (after the age of 30), but some people might start developing permanent weakness.
Most people can manage the condition with medications and by avoiding triggers. Still, severe attacks can sometimes be serious and may require hospital care. Living with frequent episodes can also affect your work, social life and emotional well-being. Treatment options are available to help you manage the physical and emotional effects of this condition.
Life-threatening complications aren’t common. In rare cases, serious problems, like breathing trouble or pneumonia, can lead to early death. Your healthcare provider can work with you to lower these risks and help you manage symptoms safely.
When your body suddenly stops working the way you expect, it’s scary. Attacks may come and go, but the uncertainty can make it hard to sleep. You may worry about waking up and not being able to move.
A healthcare provider can help you manage hypokalemic periodic paralysis (hypoPP). It may take some trial and error to find what works best. But each step — whether it’s adjusting your meals, learning your triggers or fine-tuning your medicines — can make a difference.
Keep checking in with your provider. Speak up if something isn’t helping. You are your own best advocate.
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Last reviewed on 09/24/2025.
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