Cystic lung disease is a group of conditions that cause air- or fluid-filled sacs (cysts) in your lungs. Examples include LAM, pulmonary Langerhans cell histiocytosis and Birt-Hogg-Dubé syndrome. You could be born with cystic lung disease or develop it over time. Causes include genetic conditions, autoimmune disorders, infections and smoking.
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Cystic lung disease is a name for many conditions that cause fluid- or air-filled pockets (cysts) in your lungs. The cysts can be the main sign of certain diseases. Other health conditions — like autoimmune disorders, cancer, infections or genetic diseases — can also cause them.
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Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy
Some examples of cystic lung diseases include:
Some people with cystic lung disease have no symptoms. But those who do have symptoms could experience:
Depending on the cause, you may have additional symptoms.
There are many causes of cystic lung diseases, including:
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A collapsed lung is the most common complication of cystic lung diseases. You may also get fluid around your lungs.
Healthcare providers can see cystic lung disease on imaging, like chest X-rays and high-resolution CT scans (HRCT). During pregnancy, your provider might see cysts on a prenatal ultrasound. Your provider might also recommend:
Treatment for cystic lung disease depends on the type you have. Some treatments could include:
There are also medications that treat specific diseases. If you’ve had a collapsed lung, your provider may recommend pleurodesis. This is a procedure that attaches your lung to your chest cavity to prevent lung collapse from happening again.
Talk to your healthcare provider if you or your child has symptoms like a chronic cough or shortness of breath. These symptoms can have many causes, but it’s always important to get them checked out, especially if they’re getting worse over time.
If you have a cystic lung disease diagnosis, be sure to attend follow-up appointments. Let your provider know how you’re managing any kind of treatment you’re on and if you have new or worsening symptoms.
It might be helpful to ask your provider:
Some cystic lung diseases, like LAM, can be serious because of the damage they do to your lungs. Some need to be watched closely because they can cause problems outside of your lungs that appear later in life. Others may not cause serious symptoms or can get better with treatment. Talk to your provider about what to expect in your specific situation.
Cystic lung disease can have many causes and outcomes. Your provider will be able to tell you more about your (or your child’s) specific condition and the treatment options available. Don’t hesitate to bring up questions or concerns you have.
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Last reviewed on 06/25/2025.
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