Mycoplasmas are a unique type of bacteria that can cause infections. Mycoplasmas don’t have cell walls, so common antibiotics like penicillin won’t effectively kill them. Some infections don’t need treatment. But if you do, your healthcare provider will prescribe a special kind of antibiotic that can destroy the bacteria and make you feel better.
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Mycoplasma is a bacterium (singular form of bacteria) that can lead to bacterial infections. Different types of mycoplasmas target specific areas of your body, including your lung (respiratory) system and urinary system, as well as your genitals. Mycoplasmas that cause lung infections are the most common type.
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Mycoplasmas are unique because, unlike other bacteria, they don’t have cell walls. Standard antibiotics destroy most bacteria by weakening their cell walls. Since mycoplasmas don’t have cell walls, those antibiotics don’t work on them. While most mycoplasma infections will go away on their own, healthcare providers will sometimes use special antibiotics to kill the bacterium and get you feeling well again.
There are three main types of mycoplasma that cause bacterial infections:
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Some mycoplasma infections don’t cause symptoms. You may not even know you have an infection at first. If you do have mycoplasma symptoms, they may last from just a few days up to a month. Symptoms may appear two to three weeks after exposure to the bacterium. The most common symptoms of Mycoplasma pneumoniae infections include:
Rarely, you may develop a type of mycoplasma rash. This skin condition can range from mild redness to severe, painful blisters.
Mycoplasma is a contagious bacterium. Mycoplasma pneumoniae easily spreads from an infected person to others nearby in tiny droplets that become airborne after a cough or sneeze. Respiratory mycoplasma infections are contagious for an average of 10 days.
Mycoplasma pneumoniae infections can affect anyone. But certain risk factors increase your chances of developing the condition, including:
Complications of a mycoplasma infection may include:
Your healthcare provider will perform a physical exam and ask you about your symptoms. They’ll ask about your medical history and whether you live or spend time in a crowded environment. You may need a chest X-ray to confirm a Mycoplasma pneumoniae infection. Sometimes, providers request other imaging tests, like CT scans.
Several lab tests can help your provider diagnose or confirm a mycoplasma infection. These include:
Some mycoplasma infections resolve on their own, so treatment isn’t always necessary, especially if you have very mild symptoms. You can take over-the-counter (OTC) medications to relieve your symptoms if you’re congested or have a cough.
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If you think you have a more severe infection, talk to your healthcare provider about mycoplasma treatment options. They may prescribe you an antibiotic that can effectively kill the bacteria.
While many antibiotics are ineffective at destroying mycoplasma bacteria, the macrolide class of antibiotics can usually eliminate them. These antibiotics include:
Other possible antibiotic options include a tetracycline, like doxycycline. If you’re immunocompromised, your provider may recommend fluoroquinolone (levofloxacin).
After you begin antibiotics, your symptoms will often decrease after two to three days. But respiratory infections may take weeks to completely resolve. Contact your healthcare provider if you still feel sick or have symptoms after you’ve completed your antibiotics.
If you experience symptoms that persist, like cough and fever, or worsening symptoms like wheezing, visit your healthcare provider for treatment.
If you have difficulty breathing or a high fever that lasts more than a couple of days, go to your nearest emergency room immediately.
Infections from mycoplasma bacteria vary based on the type and location of the infection in your body.
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Your healthcare provider may test for the type of bacteria that caused your infection. Treatment should help you start to feel better after a few days. Some symptoms may persist after you finish treatment but should go away in a few weeks.
With antibiotics, your symptoms should start to fade after a couple of days. If you have Mycoplasma pneumoniae, your cough could last a few weeks after you’ve finished your antibiotics.
There’s no vaccine to prevent mycoplasma infections, and the bacteria are highly contagious. But you can take steps to protect yourself and others from the bacteria by:
Mycoplasma is a highly contagious bacterium that can cause bacterial infections. While the condition usually isn’t too serious, you still want to keep an eye on your symptoms. Any symptoms that don’t go away or seem to be getting worse should be checked out by a healthcare provider. They can prescribe you a specific kind of antibiotic that destroys bacteria without cell walls. You may have to try a couple of different antibiotics until you find one that works, but you should feel better soon.
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Last reviewed on 05/28/2025.
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