Primary ciliary dyskinesia (PCD) is a rare, inherited disorder. It affects cilia, tiny hair-like organs that help your body clear mucus. PCD leads to recurring, often severe respiratory infections. It can also cause abnormal organ placement in a developing fetus. Adults and children with this diagnosis need ongoing treatments and monitoring.
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Primary ciliary dyskinesia (PCD) affects your respiratory system and is a rare disorder. It’s due to issues with cilia, microscopic hair-like organs. Healthy cilia use wave-like motions to move cells and other substances within your body.
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Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy
With primary ciliary dyskinesia, cilia may:
Cilia line tissue in the respiratory system and other areas. Here, they help eliminate germs, waste and substances, like dust. They also play a role in the placement of developing organs in a fetis.
They can cause health issues beginning at birth or later in life, such as:
Primary ciliary dyskinesia is passed down in families through gene abnormalities (mutations). There are dozens of mutations that can cause the disease.
Symptoms are often present at birth and worsen over time.
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There is no single test that can confirm a PCD diagnosis. Evaluations include:
Other tests that may indicate a primary ciliary dyskinesia diagnosis include:
There is no cure for PCD. But treatment can slow disease progression.
Therapies that help you eliminate mucus and fluids include:
Care may also include medications for infections and inflammation:
Surgery may be necessary to treat abnormal organ placement. Care may include repairing abnormal structures shortly after birth. Additional procedures may be needed to prevent or treat complications later in life.
The condition is inherited, so there is nothing you can do to prevent it. If you are thinking of starting a family and a close relative has PCD, you may wish to consider genetic testing and counseling. These services help you learn the likelihood of having a child with the disease.
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Many people live a long life, even into older adulthood.
The prognosis varies. Some people are sick at birth and remain so throughout their lives. Other people feel healthy between periods of illness that may sometimes be severe.
Ongoing infections from primary ciliary dyskinesia can scar organ tissue, leading to complications. These include:
Steps you can take to feel your best include:
A note from Cleveland Clinic
Primary ciliary dyskinesia is a rare, inherited disorder affecting the respiratory system and organ placement. Symptoms worsen, sometimes causing respiratory failure and other complications. But there are steps you can take to feel your best. Airway clearance techniques and medications lower your infection risk. Emotional support can ease some of the stress of living with this chronic disease.
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Last reviewed on 02/04/2022.
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