Periventricular leukomalacia (PVL) is a type of brain injury that affects the white matter. Preterm babies are most at risk for this condition. PVL varies widely in severity and can lead to developmental delays and other symptoms. It also increases your child’s risk of cerebral palsy. PVL has no cure, but therapy can help improve your child’s day-to-day life.
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Periventricular leukomalacia (PVL) is damage to the inner part (white matter) of a baby’s brain. White matter is made up of the “wires” that neurons (brain cells) use to communicate with other parts of your brain and spinal cord.
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Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy
If your baby has periventricular leukomalacia, there’s damage to some part of their white matter. This may lead to motor (movement) and cognitive (mental) developmental delays. They’ll also have a higher risk of cerebral palsy.
It may help to break down the condition’s name to better understand it:
In other words, periventricular leukomalacia is the softening (damage) of white matter around the ventricles in your baby’s brain.
Babies born before 32 weeks’ gestation (very preterm) are most at risk for developing PVL. The younger their gestational age (or the more pre-term they’re born), the greater the risk.
If you had a preterm delivery, your mind may be spinning with questions and concerns about your baby’s health and future. Know that your baby’s healthcare team will help you understand how this condition may affect your baby — and family — and offer guidance and support.
You generally can’t tell that a baby has periventricular leukomalacia by looking at them — there may not be any physical signs. But over time, they may develop any of the following due to PVL:
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These conditions typically appear by age 2. PVL affects every baby differently.
PVL occurs when not enough blood or oxygen gets to your baby’s brain, either before or after they’re born. Babies born preterm or small for their gestational age are most at risk. This is because their brains are still developing and may be more likely to be injured.
Other conditions linked to PVL include:
If your baby is born preterm, their healthcare team may recommend screening tests in their first several days and weeks. In other cases, your baby may not receive testing for the condition until they show signs of it, like developmental delays.
Tests that can diagnose PVL include:
There isn’t a direct treatment or cure for periventricular leukomalacia. Brain damage from PVL is permanent. But several therapies can help manage symptoms and improve your child’s quality of life. These therapies may include:
There’s nothing you can directly do to prevent periventricular leukomalacia. The main goal is to try to prevent preterm birth. If you’re at risk for having your baby preterm, going to a medical facility that specializes in preterm delivery may help prevent this condition.
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You can’t always prevent preterm delivery, but taking the following steps during pregnancy can help reduce your risk:
No two children with periventricular leukomalacia are affected in the same way. The prognosis (outlook) depends on several factors, like the severity of the brain damage and any other health conditions your child may have.
Some children have minimal to no symptoms, while others face significant physical and/or intellectual disabilities. Your providers should be able to give you a sense of the severity of the injury that your baby has and how this may affect their development.
It’s impossible to predict how your baby will be affected. The best way you can prepare is to talk to healthcare providers who specialize in researching and treating PVL. As they grow, your child may benefit from a team of specialists who can care for their needs.
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Most babies with periventricular leukomalacia can expect to live a full lifespan. If your baby has severe brain damage or other associated medical conditions, then they may have a shorter life expectancy. Factors that may affect their lifespan include:
Having a baby can be an overwhelming time, especially if your baby comes very early or requires a NICU stay. And sometimes, the days and weeks that follow are filled with more healthcare providers and tests than you imagined possible. You may feel out of control or look for someone to blame — even yourself. But with periventricular leukomalacia (PVL), there’s no one to blame. Even researchers aren’t exactly sure what causes it. And PVL affects every child differently. So, it’s important to lean on your child’s healthcare team to provide the best medical care, advice and support as your child grows. Be sure to take care of yourself, too.
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When your child has a neurological condition, you want them to have the best care. At Cleveland Clinic Children’s, we offer compassionate, personalized treatment.
Last reviewed on 04/11/2025.
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