As the body’s largest organ, skin protects against germs, regulates body temperature and enables touch (tactile) sensations. The skin’s main layers include the epidermis, dermis and hypodermis and is prone to many problems, including skin cancer, acne, wrinkles and rashes.


layers of the skin
The three layers of skin on top of muscle tissue.

What is the skin?

The skin is the body’s largest organ, made of water, protein, fats and minerals. Your skin protects your body from germs and regulates body temperature. Nerves in the skin help you feel sensations like hot and cold.

Your skin, along with your hair, nails, oil glands and sweat glands, is part of the integumentary (in-TEG-you-MEINT-a-ree) system. “Integumentary” means a body’s outer covering.


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What are the layers of the skin?

Three layers of tissue make up the skin:

  • Epidermis, the top layer.
  • Dermis, the middle layer.
  • Hypodermis, the bottom or fatty layer.

What does the epidermis (top layer of skin) do?

Your epidermis is the top layer of the skin that you can see and touch. Keratin, a protein inside skin cells, makes up the skin cells and, along with other proteins, sticks together to form this layer. The epidermis:

  • Acts as a protective barrier: The epidermis keeps bacteria and germs from entering your body and bloodstream and causing infections. It also protects against rain, sun and other elements.
  • Makes new skin: The epidermis continually makes new skin cells. These new cells replace the approximately 40,000 old skin cells that your body sheds every day. You have new skin every 30 days.
  • Protects your body: Langerhans cells in the epidermis are part of the body’s immune system. They help fight off germs and infections.
  • Provides skin color: The epidermis contains melanin, the pigment that gives skin its color. The amount of melanin you have determines the color of your skin, hair and eyes. People who make more melanin have darker skin and may tan more quickly.


What does the dermis (middle layer of skin) do?

The dermis makes up 90% of skin’s thickness. This middle layer of skin:

  • Has collagen and elastin: Collagen is a protein that makes skin cells strong and resilient. Another protein found in the dermis, elastin, keeps skin flexible. It also helps stretched skin regain its shape.
  • Grows hair: The roots of hair follicles attach to the dermis.
  • Keeps you in touch: Nerves in the dermis tell you when something is too hot to touch, itchy or super soft. These nerve receptors also help you feel pain.
  • Makes oil: Oil glands in the dermis help keep the skin soft and smooth. Oil also prevents your skin from absorbing too much water when you swim or get caught in a rainstorm.
  • Produces sweat: Sweat glands in the dermis release sweat through skin pores. Sweat helps regulate your body temperature.
  • Supplies blood: Blood vessels in the dermis provide nutrients to the epidermis, keeping the skin layers healthy.

What does the hypodermis (bottom layer of skin) do?

The bottom layer of skin, or hypodermis, is the fatty layer. The hypodermis:

  • Cushions muscles and bones: Fat in the hypodermis protects muscles and bones from injuries when you fall or are in an accident.
  • Has connective tissue: This tissue connects layers of skin to muscles and bones.
  • Helps the nerves and blood vessels: Nerves and blood vessels in the dermis (middle layer) get larger in the hypodermis. These nerves and blood vessels branch out to connect the hypodermis to the rest of the body.
  • Regulates body temperature: Fat in the hypodermis keeps you from getting too cold or hot.


What else makes up the skin?

One inch of your skin has approximately 19 million skin cells and 60,000 melanocytes (cells that make melanin or skin pigment). It also contains 1,000 nerve endings and 20 blood vessels.

Conditions and Disorders

What conditions and disorders affect the skin?

As the body’s external protection system, your skin is at risk for various problems. These include:


How can I protect my skin?

You lose collagen and elastin as you age. This causes the skin’s middle layer (dermis) to get thinner. As a result, the skin may sag and develop wrinkles.

While you can’t stop the aging process, these actions can help maintain healthier skin:

  • Apply sunscreen every day (even if you’re mostly indoors). Choose a sunscreen with a broad-spectrum sun protection factor (SPF) of at least 30.
  • Don’t tan indoors or outdoors. Tanning causes skin damage. It ages skin and can cause skin cancer.
  • Find healthy ways to manage stress. Stress can make certain skin conditions worse.
  • Perform regular skin and mole checks to look for changes that may be signs of skin cancer.
  • Quit smoking and using tobacco products. Nicotine and other chemicals in cigarettes and electronic cigarettes age skin faster.
  • Use gentle cleansers to wash your face in the morning and at night.
  • Shower regularly and apply moisturizing lotion to prevent dry skin.

Additional Common Questions

When should I talk to a doctor?

You should call your healthcare provider if you experience:

  • Change in size, color, shape or symmetry of a mole.
  • Skin changes like a new mole.
  • A cut that a household bandage can’t close (that may need stitches).
  • Severe, blistering burns.
  • Signs of skin infections like red streaks or yellow discharge.
  • Unexplained skin rash or skin condition.

A note from Cleveland Clinic

As the body’s largest organ, your skin plays a vital role in protecting your body from germs and the elements. It keeps your body at a comfortable temperature, and nerves beneath the skin provide the sense of touch. This external body covering can have serious problems like skin cancer, as well as more common issues like acne and skin rashes. Your healthcare provider can offer tips to help keep skin healthy.

Medically Reviewed

Last reviewed on 10/13/2021.

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