Oxidative Stress

What is oxidative stress?

Oxidative stress is an imbalance between two different types of molecules in your body: free radicals and antioxidants. Specifically, it means there are too many free radicals and not enough antioxidants. As a result, the excess free radicals start to harm your body’s cells and tissues. They damage the different parts of cells, including lipids (fats) and proteins, that allow them to work normally.

Researchers believe oxidative stress plays a role in the onset of many chronic and degenerative conditions. A few examples include:

• Cancer. Oxidative stress damages the DNA in healthy cells, which can raise your cancer risk.
• Cardiovascular disease. Oxidative stress triggers plaque to form in your arteries (atherosclerosis). Plaque buildup can lead to many different problems, including reduced blood supply to your heart (coronary artery disease) and heart attack.
• Kidney disease. Sustained oxidative stress can form scar tissue in your kidneys that prevents them from working as they should. This may lead to kidney failure, which can worsen to the point where you need dialysis.
• Neurological diseases. Researchers have linked oxidative stress to many different neurological diseases, including Alzheimer’s disease, Parkinson’s disease and multiple sclerosis. Excess free radicals contribute to neuron loss, which can progressively lead to dementia.
• Respiratory diseases. Oxidative stress and related inflammation can affect your lungs and cause conditions like asthma or chronic obstructive pulmonary disease (COPD).
• Rheumatoid arthritis. Free radicals contribute to the chronic inflammation that happens in people with rheumatoid arthritis.

What is the difference between free radicals and antioxidants?

Free radicals can harm you if there are too many in your body (oxidative stress). Antioxidants, on the other hand, can help protect your body from such damage.

To understand how this all works, it helps to know a bit more about what free radicals and antioxidants do in your body. Free radicals and antioxidants are two different types of molecules, or chemical compounds, that play a role in how your body works. Your body needs both types to function properly.

Your body converts the food you eat into energy. This normal, necessary process leads to the production of free radicals. They’re simply a byproduct. While free radicals often have a bad reputation, they’re actually not always bad. Free radicals support the work of your immune system and other crucial body processes. But you only need low or moderate levels of them.

Extensive sun exposure, stress and smoking can cause your body to make more free radicals than it needs. This overload can cause problems.

Free radicals are unstable molecules. In chemistry terms, this means they’re missing an electron. They need a certain number of electrons to be stable, or complete. Free radicals search for electrons they can grab from other molecules in your body to regain their stability. This puts healthy, complete molecules in your body at risk. Free radicals can snatch electrons from those molecules, in turn damaging them and making them unstable.

But just like in the movies, a superhero can sweep in to save the day. Antioxidants, or natural substances in foods we eat, are that superhero. Unlike free radicals, antioxidants don’t snatch electrons from healthy cells in your body. Instead, they donate one of their electrons to a free radical. This makes the free radical complete, so it doesn’t steal from other molecules in your body. Antioxidants help keep balance in your body.

When you don’t have enough antioxidants to satisfy the free radicals, those free radicals go scavenging. And your body experiences oxidative stress as a result.

What causes oxidative stress?

Anything that raises the number of free radicals in your body to unhealthy levels can cause oxidative stress. Healthcare providers sometimes call such culprits environmental factors, or environmental triggers. Known examples include:

• Pollution in the environment around you.
• Smoking and tobacco use.
• Sun exposure.
• Drinking too much alcohol.
• Stress.

What are oxidative stress symptoms?

You might not always know your body is experiencing oxidative stress. It involves tiny, microscopic changes that go on behind the scenes. You may not have any symptoms for a while, and when you do, they can vary widely depending on which parts of your body are affected.

For example, extensive sun exposure can cause sun-damaged skin. This is when ultraviolet (UV) radiation from the sun changes the DNA in your skin’s cells. Signs you might notice include:

• Fine lines and wrinkles.
• Sun spots.
• Spider veins.

In other cases, oxidative stress doesn’t cause visible changes. But you may start to feel its effects once it causes substantial damage. For example, the buildup of plaque (sticky substances that include cholesterol) in your arteries can lead to symptoms of cardiovascular disease. These might include chest pain, shortness of breath, fatigue and heart attacks.

A healthcare provider can tell you more about what you might expect in your individual situation.

How can I reduce oxidative stress?

Adding foods rich in antioxidants is one way to reduce oxidative stress. Healthcare providers recommend getting antioxidants from a variety of foods. That’s because there isn’t one antioxidant that’s a superfood or responsible for knocking out all the free radicals. Lots of antioxidants work together to achieve the greatest health benefit.

This chart lists some key antioxidants and examples of foods that contain them.

In some cases, healthcare providers recommend taking dietary supplements to help you get the antioxidants you need. But in general, getting your nutrients from food is best.

The Mediterranean diet is a way of eating that’s high in antioxidants. Research has shown it has many benefits for your health. And you can talk to a dietitian to get advice tailored to your unique nutritional needs.