Carcinogens are substances that may increase your risk of cancer. There are more than 100 known carcinogens. Carcinogens may be physical, such as ultraviolet rays from the sun; chemical, like asbestos; or biological, such as infections caused by certain viruses. Simply having contact with a carcinogen doesn’t mean you’ll develop cancer.
Carcinogens (pronounced “kahr-sin-o-jens”) are substances that may increase your risk of developing cancer. Experts have identified more than 100 carcinogens. Carcinogens may be physical, such as ultraviolet rays from the sun; chemical, like asbestos; or biological, such as infections caused by certain viruses. Simply having contact with a carcinogen doesn’t mean you’ll develop cancer. While you may not be able to avoid some carcinogens, there are steps you can take to reduce your risk of developing cancer from carcinogen exposure.
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To understand how carcinogens cause cancer, it may help to know more about the relationship between carcinogens and your genetic makeup.
Your DNA is in your genes. Your genes contain instruction manuals for making proteins. Proteins control millions of actions, including how cells grow and multiply. When a carcinogen changes your DNA, it triggers a chain reaction that turns normal cells into cancerous cells.
Sometimes, carcinogens do direct damage to your DNA so it stops working as it should. Other times, cells that typically repair DNA damage from carcinogens can’t take care of the issue. Left unrepaired, damaged DNA may lead to changes (mutations) in certain genes.
Depending on the specific mutation or change, your genes may start giving cells instructions to multiply uncontrollably, becoming cancerous tumors or blood cancer. But cancer doesn’t develop right away. Carcinogens build up over time. It may take years before a carcinogen in your body begins the chain reaction that leads to cancer.
You may have contact with a carcinogen if:
Again, simply having contact with a carcinogen doesn’t mean you’ll develop cancer. Factors that increase cancer risk include:
In the United States, the National Toxicology Program (NTP) evaluates research and publishes lists of known and possible carcinogens. The International Agency for Research on Cancer (IARC) also evaluates research and publishes its findings.
In general, both agencies rely on laboratory tests and epidemiology research (studies in people) to determine if a substance is a carcinogen.
The most recent NTP report lists 63 carcinogenic substances. The report also lists 193 substances that may cause cancer. The most recent IARC research lists 122 substances known to cause cancer, 93 substances that probably cause cancer and 319 substances that may cause cancer.
The IARC has three categories of carcinogens:
Some common carcinogens include:
Unfortunately, you can’t avoid all carcinogens. But you can avoid some known carcinogens by:
You may want to talk to a provider if you use tobacco or regularly drink beverages containing alcohol. Providers may recommend programs to help you quit smoking. They may recommend you cut back on the amount of beverages with alcohol that you drink.
You may want to ask a provider about your lifetime risk of developing cancer. (The National Cancer Institute publishes lifetime risk data.) If you have an increased lifetime risk of a certain cancer, you may want to avoid carcinogens linked to that type of cancer.
Depending on your situation, a provider may recommend you have specific cancer screening tests.
A note from Cleveland Clinic
Carcinogens are substances that can cause cancer. There are more than 100 known carcinogens. You may encounter carcinogens in your daily life. For example, there may be tiny amounts of arsenic in drinking water. Ultraviolet rays from the sun are carcinogens. There may be carcinogenic chemicals in your home or workplace.
You may worry that you don’t know enough to decide if you’re at risk. That’s understandable. But research shows the carcinogens mostly likely to cause cancer involve common lifestyle activities you can manage. For example, tobacco is a known carcinogen linked to several cancers. You can reduce your risk by quitting tobacco.
If you’re concerned about carcinogen exposure, talk to a healthcare provider. They’ll evaluate your overall situation and provide perspective on your personal risk of cancer from carcinogens. Knowledge is power. Knowing your risk and how to reduce it will help you manage your overall health. More than that, it may give you peace of mind.
Last reviewed by a Cleveland Clinic medical professional on 06/19/2023.
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