Preparing for your colonoscopy is important. Bowel prep begins days before your exam. Follow your provider’s instructions on the SUPREP bowel prep exactly to avoid last-minute cancellations.
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SUPREP® is a brand name for a medication that contains polyethylene glycol (PEG) and magnesium sulfate. It cleans out your colon (large intestine) to prepare it for a colonoscopy. PEG works by pulling water into your colon so it’s easy to have a bowel movement. Magnesium sulfate stimulates the nerves that control bowel movements.
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Bowel prep completely empties your colon of stool. It’s essential because it gives your gastroenterologist the best view of the lining of your colon. It helps them identify polyps that may lead to cancer. For your doctor, a clean colon is like driving on a clear, sunny day. A dirty colon is like driving in a rainstorm.
SUPREP bowel prep comes in a kit that contains two small bottles of solution and a mixing container. To make the bowel prep drink, you empty one of the small bottles into the mixing container. Then, you fill the container with cool water to the fill line. Be sure to follow the instructions carefully before making the drink.
If you’re a Cleveland Clinic patient, you must follow the instructions for bowel preparation exactly as prescribed or your colonoscopy will be canceled.
The following instructions are key to a successful colonoscopy:
A responsible adult driver must be with you when you check in before your colonoscopy. They must stay in the waiting area until you’re discharged. You’re not allowed to leave alone after your colonoscopy. If you don’t have a driver with you to take you home, your exam will be canceled.
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For your safety, certain medications will need to be stopped or adjusted before you can have your procedure. These include:
Medications like aspirin, antibiotics or diuretics should be taken the day of the exam with a sip of water.
If you’re unsure about which medications you can continue to take, please contact your healthcare provider.
Stop eating these high-fiber foods three days before your colonoscopy:
You should only drink clear liquids beginning the day before your colonoscopy. Don’t eat any solid foods.
You can continue to drink clear liquids until three hours before your colonoscopy. The chart shows what you can and can’t drink:
OK to Drink (No Red, Purple or Orange Liquids) | DO NOT DRINK |
---|---|
Gatorade or Powerade in yellow, green or blue | Alcohol |
Clear broth or bouillon | Milk or non-dairy creamer |
Coffee or tea (no milk or creamer. Sugar and sugar substitutes are OK) | Noodles or vegetables in broth |
Sodas/soft drinks | Juice with pulp |
Kool-Aid or other fruit-flavored drinks in yellow, green or blue | Liquid you can’t see through |
Strained fruit juices (no pulp) | |
Jell-O, Popsicles, hard candy (not red, purple or orange) | |
Water | |
OK to Drink (No Red, Purple or Orange Liquids) | |
Gatorade or Powerade in yellow, green or blue | |
DO NOT DRINK | |
Alcohol | |
Clear broth or bouillon | |
DO NOT DRINK | |
Milk or non-dairy creamer | |
Coffee or tea (no milk or creamer. Sugar and sugar substitutes are OK) | |
DO NOT DRINK | |
Noodles or vegetables in broth | |
Sodas/soft drinks | |
DO NOT DRINK | |
Juice with pulp | |
Kool-Aid or other fruit-flavored drinks in yellow, green or blue | |
DO NOT DRINK | |
Liquid you can’t see through | |
Strained fruit juices (no pulp) | |
DO NOT DRINK | |
Jell-O, Popsicles, hard candy (not red, purple or orange) | |
DO NOT DRINK | |
Water | |
DO NOT DRINK | |
Note: Brand names are registered trademarks.
Take the bowel preparation in two parts. You can refrigerate the solution, but don’t add ice, sugar or any flavorings.
Part 1: 6:00 p.m. on the evening before your colonoscopy
Part 2: six hours before colonoscopy
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Some people's bowels move slowly, and they may need different instructions. Please see your doctor in for personalized bowel prep instructions if you have:
No. Use only water to mix the solution.
It varies. You’ll continue to poop until you have watery diarrhea.
You may take extra laxatives in the days leading up to your prep. This should help resolve your constipation before entering the bowel prep day.
Contact your physician as you’ll likely need additional bowel prep instructions.
Certain medical conditions and medications can slow bowel emptying or lead to constipation. Conditions like Parkinson’s, multiple sclerosis (MS) or using a wheelchair can slow down your digestion. Medications like narcotics, gabapentin and anticholinergic medications can also have an impact. Contact your physician and be sure to share your medical history and current medication use, as you’ll likely need extra time and additional laxatives to complete your bowel prep.
Start your prep two to three hours earlier to allow yourself more time to complete the entire prep.
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If you can’t finish your entire bowel prep, you’ll likely need to reschedule your colonoscopy due to poor prep quality.
Gastric bypass surgery involves your stomach and small bowel. It doesn’t change the length of your colon. You may need to drink smaller amounts, more slowly. You’ll need to complete the entire bowel prep, it may just take longer time to complete it.
Please consult your nephrologist before scheduling to get instructions that are specific to you. In general, dialysis patients take the Golytely bowel prep and have the procedure on the same day of their dialysis (colonoscopy in AM, dialysis in PM).
If you can pour it in a glass and you can see through it, it’s considered "clear liquid."
An adult must be present with you at check-in for your colonoscopy and remain in the endoscopy area until you’re discharged. You can hire a driver to take you home only if this adult escort is with you at check-in, remains in the endoscopy area until you’re discharged, and takes the hired ride home with you.
No, you must have an adult with you when you check in for your procedure. Your responsible adult must remain in the endoscopy center during your procedure and then drive you home. You can’t drive a vehicle for the rest of the day.
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Bowel preparation is an important part of your colonoscopy. Make sure to follow your gastroenterologist’s instructions on how to do this. Having a clear colon makes it easier for them to detect polyps and other abnormalities. Be sure to ask them any questions you have about using SUPREP bowel prep before you begin.
A colonoscopy or other screening is an important test for colon cancer. The team at Cleveland Clinic can give you peace of mind and expert care when you need it.
Last reviewed on 04/22/2025.
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