Golytely, Nulytely, Trilyte or Colyte Bowel Preparation Instructions

What is Golytely, Nulytely, Trilyte and Colyte bowel preparation?

Golytely, Nulytely, Trilyte, and Colyte are brand names for a medication called polyethylene glycol 3350 with electrolytes. These medications clean out your colon (large intestine) to prepare it for a colonoscopy. They work by softening your poop (stool) so it’s easy to have a bowel movement. The electrolytes in the mixture help prevent dehydration.

Why is bowel preparation important?

Preparing for a colonoscopy with a bowel preparation kit is essential. It completely empties your colon of stool. This gives your gastroenterologist the clearest view of the lining of your colon so they can identify polyps or cancer. When your colon isn’t completely clear, they can’t identify problems, and your colonoscopy results may not be accurate. For your doctor, a clean colon is like driving on a clear, sunny day. A dirty colon is like driving in a rainstorm.

How do I use Golytely, Nulytely, Trilyte and Colyte?

Golytely, Nulytely, Trilyte and Colyte come as powder solutions in a large jug. The day before your colonoscopy, you’ll add a specific amount of water to the jug. Be sure to follow the instructions on the label carefully.

Once you add water to the solution, it creates a laxative that you drink. Your colon should be clear by the time you finish drinking the entire jug (if you followed all the instructions correctly).

If you’re a Cleveland Clinic patient, you must follow the instructions for bowel preparation exactly as prescribed or your colonoscopy will be canceled.

Key preparation instructions

The following instructions are key to a successful colonoscopy:

• Your bowel must be empty so that your doctor can clearly view your colon. Follow the instructions you get from your gastroenterologist exactly as they are written.
• Don’t eat any solid food the entire day before your colonoscopy. Drink only clear liquids.
• Get your bowel preparation kit at least five days before your colonoscopy.

Transportation on the day of your colonoscopy

A responsible adult driver must be with you when you check in before your colonoscopy. They must stay in the waiting area until you’re discharged. You’re not allowed to leave alone after your colonoscopy. If you don’t have a driver with you to take you home, your exam will be canceled.

Medications

For your safety, certain medications will need to be stopped or adjusted before you can have your procedure. These include:

• Blood thinners: Contact your provider at least two weeks before the procedure about adjusting your medication. Examples of blood thinners include clopidogrel (Plavix®), warfarin (Coumadin®), ticlopidine hydrochloride (Ticlid®), anagrelide (Agrylin®), rivaroxaban (Xarelto®), dabigatran (Pradaxa®), apixaban (Eliquis®) and prasugrel (Effient®).
• Insulin and diabetes medication: Always call the provider who orders these medications for instructions on changing the dosage leading up to your colonoscopy. Don’t take your diabetes pills after midnight on the day of your procedure. If you’re taking insulin, like as insulin glargine injection (Lantus®), insulin lispro (Humalog®), long-acting insulin like insulin isophane (HumulinN®, NovolinN®, ReliOn®) or 70/30 insulin, take half your normal dose the day before your procedure.
• Weight management medication: If you take medications for weight-loss, your dosage may need to be adjusted, or you might need to stop taking it several days to a week before. Contact the doctor who prescribes this medication for further instructions. Weight loss medications that you’ll need to stop include canagliflozin (Invokana®), dapagliflozin (Farxiga®, Forxiga®), dulaglutide (Trulicity®), empagliflozin (Jardiance®), ertugliflozin (Steglatro®), exenatide (Byetta®, Bydureon®), liraglutide (Victoza®, Saxenda®), lixisenatide (Adylyxin®), semaglutide (Ozempic®, Wegovy®, Rybelsus®) and tirzepatide (Mounjaro®, Zepbound®).
• Iron pills: Stop taking them one week before your colonoscopy.

Medications like aspirin, antibiotics or diuretics should be taken the day of the exam with a sip of water.

If you’re unsure about which medications you can continue to take, please contact your healthcare provider.

Three days before your colonoscopy

Stop eating these high-fiber foods three days before your colonoscopy:

• Popcorn
• Beans
• Seeds (flax, sunflower, quinoa)
• Multigrain bread
• Nuts
• Salad/vegetables
• Fresh and dried fruit

One day before your colonoscopy

You should only drink clear liquids beginning the day before your colonoscopy. Don’t eat any solid foods.

You can continue to drink clear liquids until three hours before your colonoscopy. The table below shows what you can and can’t drink:

Note: Brand names are registered trademarks.

How to take Golytely, Nulytely, Trilyte or Colyte

Mix the solution the afternoon before your colonoscopy and refrigerate it before drinking. You may add the flavor pack that came with the bowel preparation. Don’t add ice, sugar or any other flavorings to the solution.

You’ll drink the bowel preparation solution in two parts:

Part 1: 6:00 pm the evening before your colonoscopy

• Drink one 8-ounce glass every 15 minutes (the first half of the solution)
• Return the bowel preparation to the refrigerator

Part 2: Six hours before your colonoscopy

• Drink one 8-ounce glass every 15 minutes (the remaining half of the solution)
• You may continue to drink clear liquids up to three hours before your exam
  

Some people's bowels move slowly, and they may need different instructions. Please see your doctor for personalized bowel prep instructions if you have:

• Medical conditions that need special accommodations
• Had a poor bowel prep results or failed bowel prep in the past
• Had difficulty with anesthesia during a past procedure

What are possible side effects of Golytely, Nulytely, Trilyte and Colyte?

Bowel prep with polyethylene glycol is safe and effective, but it can cause side effects. Some of those are:

• Bloating
• Cramping
• Nausea or vomiting
• Burning around your anus
  
  
  

What if I have constipation?

You may take extra laxatives in the days leading up to your prep. This should help resolve your constipation before your bowel prep day.

What if I've had poor prep results in the past?

Contact your physician as you’ll likely need additional bowel prep instructions.

What if I have motility issues from a medical condition?

Certain medical conditions and medications can slow bowel emptying or lead to constipation. Conditions like Parkinson’s, multiple sclerosis (MS) or using a wheelchair can slow down your digestion. Medications like narcotics, gabapentin and anticholinergic medications can also have an impact. Contact your physician and be sure to share your medical history and current medication use, as you’ll likely need extra time and additional laxatives to complete your bowel prep.

What if I can’t drink a large volume of liquid?

Start your prep two to three hours earlier to allow yourself more time to complete the entire prep.

What if I can't finish my bowel prep?

If you can’t finish your entire bowel prep, you’ll likely need to reschedule your colonoscopy due to poor prep quality.

Do I still have to complete the entire prep if I’ve had bariatric surgery?

Gastric bypass surgery involves your stomach and small bowel. It doesn’t change the length of your colon. You may need to drink smaller amounts, more slowly. You’ll need to complete the entire bowel prep, it may just take longer time to complete it.

What if I’m on dialysis?

Please consult your nephrologist before scheduling to get instructions that are specific to you. In general, dialysis patients take the Golytely bowel prep and have the procedure on the same day as their dialysis (colonoscopy in AM, dialysis in PM).

How do I know if something is considered a clear liquid?

If you can pour it in a glass and you can see through it, it’s considered "clear liquid."

Can I take Uber®, Lyft®, taxi or bus home?

An adult must be present with you at check-in for your colonoscopy and remain in the endoscopy area until you’re discharged. You can hire a driver to take you home only if this adult escort is with you at check-in, remains in the endoscopy area until you’re discharged, and takes the hired ride home with you.

Can I “sleep it off” here and drive myself home?

No, you must have an adult with you when you check in. Your responsible adult must remain in the endoscopy center during your procedure and then drive you home. You can’t drive a vehicle after your procedure for the rest of the day.