What is bone marrow concentrate (BMC)?

Bone marrow is the soft, spongy substance that fills the inner cavities of bones. It is where blood is produced.

Tiny spaces in the bone marrow hold blood and stem cells, the primitive cells that are able to grow into various types of blood cells. Under certain conditions, some of these stem cells can also create new tissue like bone, cartilage, fat and blood vessels.

BMC, also known as bone marrow aspirate concentrate (BMAC), is a fluid containing cells taken from bone marrow.

How is bone marrow concentrate (BMC) obtained?

The first step in producing BMC is to collect bone marrow aspirate through a minimally invasive method that uses a needle to remove bone marrow from a large bone, such as the pelvic bone. The procedure is generally done under local anesthesia, sedation or with general anesthesia. The aspirate is then put through processing that uses a centrifuge. Bone marrow processing methods vary widely and can affect the number and quality of cells, especially in terms of useful stem and progenitor cells.

What are the risks involved with obtaining bone marrow concentrate?

Risks are rare, but may include:

  • Bleeding
  • Infection
  • Pain that continues after the procedure

How is bone marrow concentrate (BMC) used to help repair or heal tissue?

Stem and progenitor cells, combined with other bone marrow cells and platelets, can be used to heal tissue when injected. Furthermore, BMC contains proteins, called cytokines and growth factors, that may help heal tissue. The proposed mechanism of action is still to be determined, as well as the clinical efficacy. However, BMC is believed to decrease (modulate) inflammation and potentially aid in new tissue formation.

BMC may:

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