Head and Neck Cancer

Association of Disease Recurrence With Survival Outcomes in Patients With Cutaneous Squamous Cell Carcinoma of the Head and Neck Treated With Multimodality Therapy

1995-2014

Despite intensified bimodality therapy, the presence of features such as deep invasion, perineural invasion, poor differentiation, positive margins, node-positive disease, and extracapular extension have been identified in the literature as factors associated with inferior outcomes in patients with cutaneous squamous cell carcinoma. This study further examines the subset of patients with disease recurrence after surgery and postoperative radiation therapy to identify survival rates after recurrence and determine the association of immune status with this outcome.

Overall Survival After Disease Recurrence After Definitive Surgery and Postoperative Radiotherapy by Immune Status (N = 205)

1994-2014

Overall Survival by Disease Recurrence Among Patients Treated With Salvage Surgery vs No Salvage Surgery (N = 205)

1994-2014

Overall Survival After Disease Recurrence for Patients Not Eligible for Salvage Surgery by Immune Status (N = 205)

1994-2014

Patients with cutaneous squamous cell carcinoma of the head and neck who experience disease recurrence after definitive treatment with surgery and postoperative radiation therapy have poor survival, irrespective of immune status. Further clinical trials evaluating the role of concurrent chemotherapy, targeted agents, and immunotherapy are warranted.

References

Sun L, Chin RI, Gastman B, et al. Association of Disease Recurrence With Survival Outcomes in Patients With Cutaneous Squamous Cell Carcinoma of the Head and Neck Treated With Multimodality Therapy. JAMA Dermatol. 2019 Apr 1; 155(4): 442-7.