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Juvenile Arthritis

The Cleveland Clinic Children’s Center for Pediatric Rheumatology and Immunology team includes physicians, nurses, physical therapists, occupational therapists, ophthalmologists and dietitians working closely together to offer our patients a comprehensive diagnostic evaluation, an integrated multidisciplinary treatment plan and follow-up care for juvenile idiopathic arthritis (JIA) and other pediatric rheumatological diseases and disorders.

Attending to patients at our main campus, Avon and Twinsburg locations, our rheumatology team is backed by Cleveland Clinic's world-class resources for expert consultation and state-of-the-art facilities and services.

Rheumatic diseases are disorders which can affect any part of the body including the joints, muscles, connective tissues, and soft tissues around the joints and bones. We evaluate and treat children with a number of rheumatic and immunological diseases including:

The Center for Pediatric Rheumatology currently cares for more than 250 children with some form of chronic arthritis. Our treatment approach is guided by national guidelines and individualized to meet the needs and expectations of our patients and their families.

Our program offers unique research and treatment opportunities for patients, including:


Our researchers are conducting multiple studies on children with JIA including collaborative studies with the NIH to identify genetic markers associated with JIA, cutting-edge therapeutic trials for new biologics in JIA, and the financial impact of JIA on the healthcare system and families.

Shared Medical Appointments

Our patients and families are invited to participate in Shared Medical Appointments where 6-8 children with JIA and their family members meet with our nurse practitioner every 3 months for an educational session and routine check-up.

The SMA is designed as a group visit consisting of a 20 minute presentation on various subjects related to your child’s arthritis, followed by a private examination to address each child’s needs. For more information about SMAs please contact us at 216.445.1099.

Pediatric Infusion Suites

Patients requiring infusion medications like Remicade®, Orencia®, or Actemra® are able to receive their infusions at the Cleveland Clinic Children’s pediatric infusion center on main campus or at satellite locations in Avon (Richard E. Jacobs Health Center) or Twinsburg.

Pediatric Radiology

During a child’s diagnosis or evaluation, imaging studies may be required. These studies help the child’s healthcare team better understand how the child’s disease is affecting their bones or joints.

Some of the most commonly ordered imaging studies for children with JIA, include:

  • MRI (magnetic resonance imaging)
  • Ultrasound
  • X-rays (radiography)

At Cleveland Clinic Children’s specially trained pediatric radiologists work closely with the child’s pediatric specialists and dedicated pediatric anesthesiologists to provide timely, accurate and effective diagnosis and treatment in a child and the family-centered environment, making the experience as comfortable as possible.

Pediatric Nutrition Services

Nutrition is a critical component to therapy for young children with chronic diseases and medical conditions. Proper nutritional support prevents malnutrition, assures appropriate physical growth and development, and helps to maintain a strong immune system.

Cleveland Clinic Children’s has a team of registered dietitians, board certified in pediatrics, who collaborate with physician teams to provide expert, evidence-based nutritional care for infants, children and adolescents.

The Pediatric Nutrition Support Team provides individual counseling to assess each child’s nutritional needs, develop the most appropriate plan of nutritional support, and monitor nutritional status to ensure an optimal outcome.

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Robert Rennebohm, MD

Robert Rennebohm, MD

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Rennebohm, Robert, MD

Location(s): Cleveland Clinic Main Campus

Department: Center for Pediatric Rheumatology and Immunology

Specialties: Susac's Syndrome, Pediatric Rheumatology, Center for Pediatric Rheumatology

Type of Doctor: Children & Adolescents Only

Surgeon: No

Education: University of California-San Diego School of Medicine


Andrew Zeft, MD

Zeft, Andrew, MD

Location(s): Cleveland Clinic Main Campus, Twinsburg Family Health & Surgery Center, Richard E. Jacobs Health Center, Hillcrest Hospital

Department: Center for Pediatric Rheumatology and Immunology

Specialties: Arthritis, Autoinflammatory Syndromes, Central Nervous System Vasculitis, Chronic Infantile Neurological, Cutaneous, and Articular (CINCA) Syndrome, Dermatophytosis, Familial Cold Autoinflammatory Syndrome, Familial Mediterranean Fever (FMF) Syndrome more

Type of Doctor: Children & Adolescents Only

Surgeon: No

Education: Medical College of Wisconsin



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Information & Appointments

While the treatment of JIA has improved dramatically in the past 15 years, there is still no cure of the disease. Scientists and physicians at Cleveland Clinic Children’s and around the world are studying ways to prevent, treat and cure arthritis in children.

Cleveland Clinic is part of the Childhood Arthritis and Rheumatology Research Alliance (CARRA). This is an organization of pediatric rheumatologists who are committed to advancing the health and quality of life of children living with rheumatic disease and arthritis and who have joined together to answer critical clinical research questions.

Below is a list of current research studies in which Cleveland Clinic Children’s is active (or soon to be active):

  • Chart Review: Efficacy & Safety of Ultrasound Guided Intra-articular Steroid Injections in Children with Juvenile Idiopathic Arthritis: A Retrospective Comparison to Non-guided Injections
  • Registry: CARRA Registry
  • Registry: Cost of Care for Juvenile Idiopathic Arthritis (JIA)
  • A Multicenter, Open-Label Study to Assess The Pharmacokinetics, Safety, and Efficacy Of Certolizumab Pegol In Children And Adolescents With Moderately To Severely Active Polyarticular-Course Juvenile Idiopathic Arthritis
  • Integrative Genomics and Juvenile Rheumatoid Arthritis
  • Pilot Study of the Safety and Efficacy of the Quadrivalent Human Papillomavirus Vaccine (Gardasil®) in Female Subjects with Juvenile Idiopathic Arthritis (JIA) / Seronegative Arthritis
  • Improved Understanding of the Biology and Use of TNF Inhibition in JIA
  • A 6-month, Multicenter, Open-label, Safety Study of VIMOVO (250 mg/20 mg, 375 mg/20 mg, and 500 mg/20 mg Naproxen/Esomeprazole) in Adolescents aged 12 to 16 Years, Inclusive, with Juvenile Idiopathic Arthritis (JIA)

As a patient of Cleveland Clinic Children’s your child may be asked to participate in a research study. While this is completely the choice and of the patient and family, we hope you will consider being a part of our effort to improve the understanding of juvenile arthritis.