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Department Orthopaedic Surgery
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon Yes
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Treatment & Services

  • Arthritis Surgery
  • Arthroplasty
  • Bone Marrow Concentrate (BMC)
  • Bone Marrow Concentrate Hip
  • Complex Primary Hip Arthroplasty
  • Complex Primary Knee Arthroplasty
  • Hip Replacement
  • Hip Revision
  • Hip Surgery
  • Hyaluronic Acid Injections
  • Joint Injections
  • Joint Preservation
  • Joint Preservation Center
  • Joint Preserving Hip Surgery
  • Joint Reconstruction
  • Joint Replacement
  • Joint Replacement of the Knee
  • Knee Arthroplasty
  • Knee Replacement
  • Knee Revision
  • Knee Surgery
  • Minimally Invasive Hip Joint Replacement
  • Minimally Invasive Knee Joint Replacement
  • Minimally Invasive Surgery
  • Orthopaedic Surgery
  • Orthopaedics
  • Platelet Poor Plasma (PPP)
  • Platelet Rich Plasma Injections (PRP)
  • Primary Joint Replacements
  • Primary Total Hip Arthroplasty
  • Primary Total Knee Arthroplasty
  • Reconstructive Surgery of the Hip
  • Reconstructive Surgery of the Knee
  • Revision Hip Arthroplasty
  • Revision Hip Joint Replacement
  • Revision Joint Replacement
  • Revision Knee Arthroplasty
  • Revision Knee Joint Replacement
  • Revision Total Hip Arthroplasty
  • Revision Total Hip Replacement
  • Revision Total Knee Arthroplasty
  • Revision Total Knee Replacement
  • Surgery
  • Surgical Treatment of Arthritis of the Hips and Knees
  • Total Knee Replacement
View all 45 Treatment & Services +

Specialty in Diseases & Conditions

  • Arthritic Knee Problems
  • Arthritis
  • Arthritis of the Hip
  • Arthritis of the Knee
  • Avascular Necrosis of the Hip
  • Avascular Necrosis of the Knee
  • Fracture Nonunion
  • Hip Pain
  • Knee Injuries
  • Knee Pain
  • Osteoarthritis
  • Osteoarthritis of the Hips in the Elderly
  • Osteoarthritis of the Knees in the Elderly
  • Osteonecrosis
View all 14 Specialties +


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About George Muschler, MD

George Muschler, MD, joined the Department of Orthopaedic Surgery in 1988. Since his arrival, he has developed a regional and national reputation in reconstructive surgery for arthritis, failed joint replacements, treatment of fractures that have failed to heal and treatment of limb deformities. He is recognized and appreciated internationally as a leader in skeletal reconstruction, bone regeneration and fracture repair. In 1999, he was appointed Research Associate in the Cleveland Clinic Office of Clinical Effectiveness, due to his work in establishing a program of patient-oriented outcomes assessment for hip and knee replacements performed in the Department of Orthopaedic Surgery. Dr. Muschler is also a member of Cleveland Clinic Taussig Cancer Center, leading and collaborating in research related to aging and adult stem cell therapies and transplantation.

In addition to his commitment to patient care, Dr. Muschler is a Vice-Chairman of the Department of Biomedical Engineering within the Cleveland Clinic's Lerner Research Institute. There he directs the Bone Biology Laboratory. This laboratory is supported by the National Institutes of Health and other funding agencies, and is focused on development of improved methods for tissue engineering and regenerative medicine. This work has provided insight into the effects of aging on stem cells of bone and cartilage, and the importance and application of these cells in development of osteoporosis, bone diseases and in the broader area of tissue repair, including bone, cartilage, tendon, nerve, muscle and skin.

Dr. Muschler has become a leader in the development of collaborative interdisciplinary programs and research teams in the area of tissue engineering and regenerative medicine, contributing significantly to both regional and national development of translational research leading to new products and therapeutic strategies. In 2005, he and colleagues at Cleveland Clinic, Case Western Reserve University, University Hospitals, NASA Glenn Research Center and the Ohio Super Computer Center established the Clinical Tissue Engineering Center (CTEC), through a grant from the Ohio Third Frontier Program. CTEC continues to serve as a catalyst for research and collaboration in the development and assessment of new therapies between over 70 Ohio investigators and over 10 Ohio institutions.

Dr. Muschler and CTEC participate in the National Center for Regenerative Medicine (NCRM), a collaboration between Cleveland Clinic and Case Western Reserve University, where he serves in the Executive Committee.

Since 2007, Dr. Muschler has served as Vice Chairman of the Orthopaedic and Rheumatologic Institute at the Cleveland Clinic, focusing efforts in the area of Research and Clinical Quality Assessment and Management.

In 2007, Dr. Muschler became Co-Director of the Armed Forces Institute for Regenerative Medicine (AFIRM), which is now an integrated national network of leading scientists and clinicians at 28 other institutions dedicated to developing new methods for treating battlefield injuries sustained by US service members.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Weill Cornell Medical, Hospital for Special Surgery
Orthopaedic Surgery
New York, NY USA

Fellowship - Memorial Sloan-Kettering Cancer Center
Musculoskeletal Oncology
New York, NY USA

Residency - University of Texas Southwestern Medical Center at Dallas
Orthopedic Surgery
Dallas, TX USA

Internship - University of Texas Southwestern Medical Center at Dallas
Surgical Internship
Dallas, TX USA

Medical Education - Northwestern University Feinberg School of Medicine
Chicago, IL USA

Undergraduate - University of Illinois Hospital at Urbana-Champaign
Urbana, IL USA

Professional Highlights

  • Director, Orthopaedic and Rheumatologic Research Center, 2005-Present
  • Director, Clinical Tissue Engineering Center (CTEC), 2005-Present
  • Vice Chairman, Department of Biomedical Engineering, 2004-Present
  • Vice Chairman for Research, Cleveland Clinic Orthopaedic and Rheumatologic Institute, 2007-Present
  • Co-Director, Armed Forces Institute for Regenerative Medicine (AFIRM), 2007-Present

Specialty Interests

Joint replacement surgery, treatment of fracture non-unions and avascular necrosis, research in regenerative tissue engineering, adult stem cell biology, health care quality assessment

Awards & Honors

  • North American Traveling Fellowship, American Orthopaedic Association, 1989
  • Career Development Award, Orthopaedic Research and Education Foundation, 1990-1992
  • J.P Ranney Award for Innovation in Regenerative Medicine and Stem Cell Research, 2006
  • Clevelands Best Doctors, Northern Ohio Live magazine, 2007

Innovations & Patents

  • Innovator in both implant design for joint surgery and limb reconstruction, as well as in the application of biological principles to the regeneration of new tissues, particularly bone.  
  • Responsible for over nine patents and recognized as inventor of the concept of selective retention as a means of rapidly concentrating and delivering a patient's own stem cells for use in tissue-healing applications. This is the basis for the Cellect TM Device, that has now been used in treatment of over 50,000 patients worldwide for bone repair following spine surgery or fractures.  


  • American Academy of Orthopaedic Surgeons
  • Orthopaedic Research Society
  • American Orthopaedic Association
  • Association of Bone and Joint Surgeons
  • International Society for Tissue Engineering
  • International Society for Stem Cell Research
  • American Society for Bone and Mineral Research
Research & Publications

Research & Publications

See publications for George Muschler, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 5/15/2023, Dr. Muschler has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Muschler receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • Fortus Medical, Inc.

Right to Future Distribution of Cleveland Clinic Financial Interest. Dr. Muschler may receive future financial benefits from the Cleveland Clinic for inventions or discoveries commercialized through the companies shown below:

  • Cell X Technologies, Inc.

Equity Dr. Muschler owns stock or stock options in the following companies for activities as a founder, inventor, discover, developer:

  • Cell X Technologies, Inc.

Fiduciary Role. Dr. Muschler serves in a fiduciary capacity, such as an elected officer, director or chief medical officer, for the following companies or other entities:

  • Cell X Technologies, Inc.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

78 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 5
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

15 Patient Comments

Reviewed on Aug 7, 2023

Dr Mushler was very thorough in explaining the procedure to me and went in depth when answering my questions. I felt like he really listened and took his time with me.

Reviewed on Jul 10, 2023

Dr. Muschler not only explained the root of my problem, he showed me, by manipulating my knee and using a model of the knee joint. Once I understood what was going on, all of my concerns immediately vanished!

Reviewed on May 15, 2023

The doctor and n/a explained in detail what the problem was and what needs to be done very good

Reviewed on May 15, 2023

I have had multiple medical procedures done at Cleveland Clinic. The hospital, physicians, staff and ancillary medical personnel are all superb. They provide the finest medical care available in this country and throughout the world. Thank you for sharing your facilities and expertise for improving the quality of life for your patients.

Reviewed on Apr 10, 2023

The Doctor was very kind and thorough. I would recommend him to anyone and be comfortable doing so. Dr. Muschler gave me options for my treatment.

Reviewed on Apr 10, 2023

All 11 of my Physicians are at the Clinic; I go nowhere else for care.

Reviewed on Mar 20, 2023

Dr. Muschler is a knowledgeable gifted doctor with great care for the patient

Reviewed on Mar 20, 2023

Dr. Muschler, Adam and Holley in addition to the Resident Pieter made me feel like there was a well functioning team at my side at all times

Reviewed on Mar 20, 2023

Dr. Muschler is the best! I am so grateful for the outstanding care he provides and his incredible skills and knowledge of his field. I trust him completely and have had wonderful outcomes with each of my two hip replacements that he has done.

Reviewed on Jan 16, 2023

Dr. Muschler did a phenomenal job on my first hip replacement that is why I am coming back to him for my second and have recommended him many times.

Reviewed on Dec 19, 2022

My experience with the doctor has been great

Reviewed on Dec 19, 2022

BothDr. Muschler and his staff were excellent

Reviewed on Nov 21, 2022

X-ray tech, nurse, and doctor were awesome. The front line staff was not friendly, short tempered, and very interested in discussing with co workers who was cooking thanksgiving turkey.

Reviewed on Oct 3, 2022

Dr Muschler is sincere, super intelligent & very helpful w/my complicated knee situation.

Reviewed on Oct 3, 2022

Dr Muschler knows his engineering & orthopedic specialty. I feel confident going to him regarding my complex 3rd knee replacement. It was worth the 2500 mile round trip to get up for an appointment.

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