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Department Neurological Institute
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English, Portuguese
Surgeon Yes
Locations Specialties & Treatments

Treatment & Services

  • Deep Brain Stimulation (DBS)
  • Gamma Knife Radiosurgery
  • Intrathecal Baclofen Pump
  • Microvascular Decompression
  • Neurological Surgery
  • Peripheral Nerve Stimulators
  • Spinal Cord Stimulation
View all 7 Treatment & Services +

Specialty in Diseases & Conditions

  • Back Pain in Athletes
  • Cancer Pain
  • Causalgia
  • Central Pain Syndrome
  • Chronic Back Pain
  • Chronic Neuropathic Pain
  • Dystonia
  • Essential Tremor
  • Failed Back Surgery Syndrome
  • Myofascial Pain Syndrome
  • Neuropathy
  • Occipital Neuralgia
  • Parkinson's Disease
  • Radiculopathy
  • Reflex Sympathetic Dystrophy (RSD)
  • Spasticity
  • Tardive Dyskinesia
  • Trigeminal Neuralgia
View all 18 Specialties +


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About Andre Machado, MD, PhD

Andre Machado, MD, PhD is the Chairman of the Neurological Institute and the Charles and Christine Carroll Family Endowed Chair in Functional Neurosurgery. Dr. Machado performs deep brain stimulation (DBS) surgery for patients with Parkinson’s disease, tremor, dystonia and obsessive-compulsive disorder as well as surgical procedures for patients with trigeminal neuralgia, intractable pain syndromes and spasticity.

Dr. Machado is a Professor of Neurosurgery at the Cleveland Clinic Lerner College of Medicine and has Joint Appointments in the Departments of Neuroscience and Biomedical Engineering. He is the past Chairman for the Joint Pain Section of the CNS/AANS and Vice-President of the American Society of Stereotactic and Functional Neurosurgery.

Dr. Machado is an Associate Chief of Staff at Cleveland Clinic and leads several enterprise-level projects with the Office of the Chief of Staff, including innovations in the model of care and a new program for professional career development.

Dr. Machado received his medical degree from the University of Sao Paulo in 1997. He completed his residency in the same institution in 2003 and obtained his PhD in 2004. He came to Cleveland Clinic in 2004, completed his fellowship in Stereotactic and Functional Neurosurgery in 2006 and has been on the staff at Cleveland Clinic since then.

Dr. Machado leads several deep brain stimulation and neuromodulation clinical trials as well as laboratory research. His research in deep brain stimulation for thalamic pain syndrome was awarded the National Institutes of Health Director’s New Innovator’s Award. His current research is aimed at developing novel treatments to promote rehabilitation after stroke and other acquired brain injuries and is funded by the NIH BRAIN initiative.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Functional Neurosurgery
Cleveland, OH

Graduate School - University of Sao Paulo Faculty of Medicine
Sao Paulo,

Residency - University of Sao Paulo Hospitals and Clinics
Sao Paulo,

Internship - Universidade de Sao Paulo
Sao Paulo,

Medical Education - University of Sao Paulo Faculty of Medicine
Sao Paulo,


  • Neurological Surgery

Specialty Interests

Stereotactic and functional neurosurgery, surgery for Parkinson's Disease, movement disorders and deep brain stimulation, surgical management of chronic pain, conditions including spinal cord stimulation, deep brain stimulation for pain, psychiatric disorders and emerging applications

Awards & Honors

  • Gildenberg Award in Stereotactic and Functional Neurosurgery

Innovations & Patents

  • Preclinical research on deep-brain stimulation for rehabilitation of motor function following strokes
  • First randomized clinical trial of deep brain stimulation for thalmic pain syndrome
  • Research in new devices for deep brain stimulation
  • Research in new devices for neuromodulation, invasive and non-invasive
  • Emerging applications of deep brain stimulation including psychiatric disorders and traumatic brain injury
    1. Intraluminal electrode assembly. US 7,532,938
    2. Methods of treating medical conditions by neuromodulation of the cerebellar pathways. US 7,640,063
    3. Methods of treating neurological conditions by neuromodulation of interhemispheric fibers. US 7,697,991
    4. Corpus Callosum Neuromodulation Assembly. US 7,725,196
    5. Method and system for treating acute heart failure by neuromodulation. US 8,818,501
    6. Methods and systems of achieving hemodynamic control through neuromodulation. 20060100667
    7. Systems and methods for neuromodulation using pre-recorded waveforms. 20080208284
    8. Methods and apparatus for securing a neuromodulation lead to nervous system tissue or tissue surrounding the nervous system. 2009007644
    9. Corpus Callosum Neuromodulation Method. US 8.942,812
Research & Publications

Research & Publications

See publications for Andre Machado, MD, PhD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 3/22/2024, Dr. Machado has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Royalty Payments. Dr. Machado receives or has the right to receive royalty payments for inventions or discoveries commercialized through the companies shown below:

  • Ceraxis Health, Inc.

Right to Future Distribution of Cleveland Clinic Financial Interest. Dr. Machado may receive future financial benefits from the Cleveland Clinic for inventions or discoveries commercialized through the companies shown below:

  • Enspire DBS
  • Ceraxis Health, Inc.
  • CardioNomic

Equity Dr. Machado owns stock or stock options in the following companies for activities as a founder, inventor, discover, developer:

  • Ceraxis Health, Inc.

Fiduciary Role. Dr. Machado serves in a fiduciary capacity, such as an elected officer, director or chief medical officer, for the following companies or other entities:

  • Ceraxis Health, Inc.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

42 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.8 out of 5
Explains 4.8
Listens 4.9
Courtesy, Respect & Concern 4.8
Patient Rating of Doctor 4.9

3 Patient Comments

Reviewed on Mar 20, 2024

John Ozinga and Dr Machado ,, talked to us in length about procedure and what thye were going to do and they would talk very good care of,our daughter.. I know she is in good hands , they treat us like family

Reviewed on Aug 28, 2023

Dr. Machado and staff were terrific !

Reviewed on Jul 5, 2023

Love Dr. Machado! He's WONDERFUL!

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