alert icon Coronavirus
Now scheduling COVID-19 vaccines for ages 5+, boosters and third doses
Schedule your appointment
COVID-19 vaccine FAQs

Going to a Cleveland Clinic location?
New visitation guidelines
Masks required for patients and visitors (even if you're vaccinated)

Department Hematology and Medical Oncology
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Treatment & Services

  • Allogeneic Hematopoietic Stem Cell Transplantation
  • Autologous Hematopoietic Stem Cell Transplantation
  • BMT (Bone Marrow Transplantation)
  • Bone Marrow Transplantation
  • Cancer Center
  • CAR T-Cell Therapy
  • Hematopoietic Stem Cell Transplantation
  • Stem Cell Transplant
View all 8 Treatment & Services +

Specialty in Diseases & Conditions

  • Graft Versus Host Disease
  • Leukemia
View all 2 Specialties +


Is Cleveland Clinic Part of Your Insurance?

Review a list of accepted insurance plans for our Northeast Ohio locations or learn more about purchasing a contracted managed care plan.

View All Plans

About Matt Kalaycio, MD

Matt Kalaycio, MD, FACP, is the former Chairman of the Department of Hematology and Medical Oncology at Cleveland Clinic Taussig Cancer Institute. Dr. Kalaycio is also a Professor in the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. Board-certified in hematology, Dr. Kalaycio's clinical interests are in leukemia and hematopoietic cell transplantation.

Dr. Kalaycio has published over 200 articles in numerous scientific publications including Bone Marrow Transplantation, Journal of Clinical Oncology, and Leukemia. He serves on the editorial board of Biology of Blood and Marrow Transplantation.  He also is the editor of a book on leukemia and co-editor of a book on clinical malignant hematology. He is the former Editor-in Chief of Hematology News.  He sits on the Board of Directors for the National Comprehensive Cancer Network (NCCN).

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Cleveland, OH USA

Fellowship - Cleveland Clinic
Medical Oncology
Cleveland, OH USA

Residency - UPMC Mercy Hospital of Pittsburgh
Internal Medicine
Pittsburgh, PA USA

Internship - UPMC Mercy Hospital of Pittsburgh
Medical Internship
Pittsburgh, PA USA

Medical Education - West Virginia University School of Medicine
Morgantown, WV USA

Undergraduate - Cornell University
Ithaca, NY USA


  • Internal Medicine - Hematology

Specialty Interests

Bone marrow transplantation, leukemia, myeloma, cancer, chronic lymphocytic leukemia, chronic myelogenous leukemia, hairy cell leukemia, leukemia

Awards & Honors

  • Castle Connelly's "America's Top Doctors"
  • Best Doctors' "Best Doctors in America"
  • Fellow, American College of Physicians
Research & Publications

Research & Publications

See publications for Matt Kalaycio, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 9/20/2021, Dr. Kalaycio has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Kalaycio receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Novartis Oncology
  • AstraZeneca

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

135 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 4.8
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 5

27 Patient Comments

Reviewed on Oct 21, 2021

Dr. Kalaycio is second to none. He is exceptional. He asks questions, listens, reviews my care, asks about my family. He has saved my life, and I trust him more than any provider I have ever seen.

Reviewed on Oct 14, 2021

Dr. Kalaycio is the best physician I've ever worked with.

Reviewed on Oct 5, 2021

Dr Kalaycio is the greatest !

Reviewed on Sep 27, 2021

Dr. Kalaycio is a wonderful doctor who combines deep expertise with a caring attitude and a great sense of humor so it always is a pleasure to see him!

Reviewed on Sep 9, 2021

Dr Kalaycio is an excellent physician

Reviewed on Aug 31, 2021

Can't begin to say enough wonderful things about Dr Kalaycio. I owe him my life! I have the utmost respect for him as a Physician. His knowledge in the field of Leukemia and Bone Marrow Transplant is an asset to CCF. It was a long hard journey but I'm glad he's the one that has walked me through It!

Reviewed on Aug 16, 2021

Dr kalaycii is brilliant, caring and informative

Reviewed on Aug 5, 2021

Dr Kalaycio's is very helpful and supportive

Reviewed on Aug 5, 2021

Dr. Kalaycio is a great doctor

Reviewed on Aug 3, 2021

Love Dr. Kalaycio!

Reviewed on Jul 26, 2021

One doctor was rushed and not as polite, but ALL others exceptional.

Reviewed on Jul 12, 2021

Dr Kalaycio excellent

Reviewed on Jul 8, 2021

I feel so very lucky that Dr. Kalaycio is my Doctor.. He always is able to put my mind at ease . I feel that he gives me clear information in a gentle way.. I don't feel like I am just a number I am so very grateful that he is my Doctor.

Reviewed on Jul 1, 2021

Dr. Kalaycio is always very kind and informative. He is straight forward and is easy to understand.

Reviewed on Jun 29, 2021

Very good doctor!

Reviewed on Jun 10, 2021

great doctor.. great care

Reviewed on Apr 29, 2021

Dr. Kalaycio is such a wonderful, caring Physician.

Reviewed on Apr 12, 2021

I love Dr. Kalaycio. He has a wonderful disposition and always puts me at ease.

Reviewed on Mar 29, 2021

Dr. Kalaycio is the best .he has been my dr. for almost 20 yrs.

Reviewed on Mar 23, 2021

I am so grateful for the care given to me by Dr Kalaycio

Reviewed on Mar 23, 2021

Doctor gave me a new outlook on my disease by taking the time to explain the prognosis.

Reviewed on Feb 25, 2021

Dr. Kalaycio is the very best doctor out there.

Reviewed on Feb 16, 2021

great doctorexplains everythingreally cares

Reviewed on Jan 26, 2021

Best Doctor Ever!

Reviewed on Jan 18, 2021

Dr. Kalaycio is just so amazing! He answers my questions in a calm concerned way . I trust him completely . I am very lucky he is my care giver.

Reviewed on Jan 12, 2021

I have been a patient of Dr. Kalaycio for over 20 years and I highly respect him and his opinion about my treatment and other concerns.

Reviewed on Nov 24, 2020

Dr. Kalaycio is very professional yet approachable. He listened to me and he made suggestions and then we came up with a course of action. I would not be here if it wasn't for Dr. Kalaycio. He is not allowed to leave or retire....when that day comes.

Related Videos Featuring Matt Kalaycio, MD

Related Videos Featuring Matt Kalaycio, MD

Back to Top