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Department Hematology and Medical Oncology
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Treatment & Services

  • Allogeneic Hematopoietic Stem Cell Transplant
  • Autologous Hematopoietic Stem Cell Transplant
  • Bone Marrow Transplant (BMT)
  • Cancer Center
  • CAR T-Cell Therapy
  • Hematopoietic Stem Cell Transplant
  • Stem Cell Transplant
View all 7 Treatment & Services +

Specialty in Diseases & Conditions

  • Graft Versus Host Disease (GvHD)
  • Leukemia
View all 2 Specialties +


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About Matt Kalaycio, MD

Matt Kalaycio, MD, FACP, is the former Chairman of the Department of Hematology and Medical Oncology at Cleveland Clinic Taussig Cancer Institute. Dr. Kalaycio is also a Professor in the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. Board-certified in hematology, Dr. Kalaycio's clinical interests are in leukemia and hematopoietic cell transplantation.

Dr. Kalaycio has published over 200 articles in numerous scientific publications including Bone Marrow Transplantation, Journal of Clinical Oncology, and Leukemia. He serves on the editorial board of Biology of Blood and Marrow Transplantation.  He also is the editor of a book on leukemia and co-editor of a book on clinical malignant hematology. He is the former Editor-in Chief of Hematology News.  He sits on the Board of Directors for the National Comprehensive Cancer Network (NCCN).

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Cleveland, OH USA

Fellowship - Cleveland Clinic
Medical Oncology
Cleveland, OH USA

Residency - UPMC Mercy Hospital of Pittsburgh
Internal Medicine
Pittsburgh, PA USA

Internship - UPMC Mercy Hospital of Pittsburgh
Medical Internship
Pittsburgh, PA USA

Medical Education - West Virginia University School of Medicine
Morgantown, WV USA

Undergraduate - Cornell University
Ithaca, NY USA


  • Internal Medicine - Hematology

Specialty Interests

Bone marrow transplantation, leukemia, myeloma, cancer, chronic lymphocytic leukemia, chronic myelogenous leukemia, hairy cell leukemia, leukemia

Awards & Honors

  • Castle Connelly's "America's Top Doctors"
  • Best Doctors' "Best Doctors in America"
  • Fellow, American College of Physicians
Research & Publications

Research & Publications

See publications for Matt Kalaycio, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 1/30/2023, Dr. Kalaycio has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

123 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 5
Courtesy, Respect & Concern 5
Patient Rating of Doctor 4.9

19 Patient Comments

Reviewed on Aug 21, 2023

Matt Kalaycio, MD has been an amazing doctor to me for the past 5+ years!

Reviewed on Aug 8, 2023

Dr Kalaycio is very caring and thorough. He is the best

Reviewed on Aug 1, 2023

Dr Kalaycio is the best in my opinion! A definite asset to CCF and the the field of Bone Marrow Transplant. He cares not only about finding a cure but in the well being of his patients as a whole. Both during treatment and down the road. I would highly recommend him to anyone!

Reviewed on Jul 27, 2023

Dr. Matt Kalaycio has cared for me for many years and I could not be in better hands.

Reviewed on Jun 12, 2023

Amazing on all fronts with this doctor and staff!! 110%

Reviewed on May 23, 2023

Dr. Kalaycio is wonderful. I would highly recommend him to anyone. He listens, is concerned and truly cares.

Reviewed on May 16, 2023

He's the best !!!

Reviewed on May 8, 2023

Dr Kalaycio was not my original transplant doctor but Dr Majhail made a good choice of who should work with me. He is easy to talk with and he understands me and my concerns. He is very direct and that's fine with me!

Reviewed on Apr 27, 2023

Dr Kalaycio always has my appointments scheduled for me.

Reviewed on Apr 25, 2023

I have already recommended Dr. Kaylaycio to others. And my appointment with him was just what I needed. I was On the verge of a big decision to take or not to take a certain drug. Dr. Kaylaycio sat down and patiently discussedAll of my concerns and made me feel like an Important part of that decision and listened patiently to my thoughts.

Reviewed on Apr 17, 2023

Dr. Kalaycio has done nothing less than the best care for me the past 17.5 years theough Cancer, Bone Marrow Transplant and post care. I am thankful I have him for a doctor.

Reviewed on Mar 23, 2023

Excellent physician, a true asset to CC

Reviewed on Mar 14, 2023

Dr kalaycio is a wonderful doctor that speaks to a patient so they understand. He provides the data and shares all the info so you understand. He's so personable too which always makes my visit comfortable.

Reviewed on Mar 9, 2023

Dr Kalaycio professional, attentive, and thorough. I couldn't be in better hands!

Reviewed on Dec 27, 2022

He is a wonderful doctor who cares about me

Reviewed on Dec 19, 2022

Dr kalaycio is a very kind and caring doctor and takes the time to listen to my questions and concerns.

Reviewed on Dec 19, 2022

My ease of appts and care by Dr kalaycio has been excellent but your other departments and satellites and care providers have been a 1-2!

Reviewed on Oct 23, 2022

The doctors & NP's were great!

Reviewed on Sep 6, 2022

I feel extremely fortunate to be under the care of Dr Kalaycio.

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