Department Global Patient Services
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages Arabic, English
Surgeon No
Locations Specialties & Treatments

Treatment & Services

  • Abnormal Liver Tests
  • Clinical Trials
  • Colonoscopy
  • Egd
  • Endoscopy
  • Flexible Sigmoidoscopy
  • Hepatology
  • Liver Biopsy
  • Liver Transplantation
  • Pediatric Liver Transplantation
  • Percutaneous Endoscopic Gastrostomy (PEG)
View all 11 Treatment & Services +

Specialty in Diseases & Conditions

  • Alpha-1 Antitrypsin Deficiency
  • Ascites
  • Autoimmune Chronic Hepatitis
  • Bile Duct Cancer
  • Bile Duct Diseases
  • Bile Duct Obstruction
  • Bile Duct Stones
  • Cirrhosis
  • Diseases of the Liver Biliary Tract and Pancreas
  • Extrahepatic Bile Duct Cancer
  • Fatty Liver Disease
  • Gallbladder Disease
  • Gallstones
  • GI Bleeding
  • Hepatitis A
  • Hepatitis B
  • Hepatitis C
  • Liver Cancer
  • Liver Disease
  • Liver-Biliary Tract Disease
  • Non Alcoholic Fatty Liver Disease
  • Paracentesis
  • Portal Hypertension
  • Primary Biliary Cirrhosis
  • Primary Sclerosing Cholangitis
View all 25 Specialties +


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About Nizar Zein, MD

Dr Zein is the Chief of Hepatology and the inaugural endowed holder of the Mikati Foundation Chair in Liver Diseases. He received several awards, including the American Liver Foundation Scholar Award, the Cleveland Clinic Innovator Award and the Distinguished Faculty Award for Research Mentorship. He has been recognized for academic excellence by the Syrian American Medical Society and honored for his leadership and community service by the Ana G. Mendez University of Puerto Rico as the recipient of Presidential Medal in 2011. He was elected to the Board of Governors of the Cleveland Clinic in 2015.

Dr Zein’s research focuses on improving disease and treatment outcome in patients with the Hepatitis C virus before and after liver transplantation.  He has authored over 200 publications, and has been the Principal Investigator of several large clinical trials. He holds several patents and established a research group at Cleveland Clinic focused on 3D printing of solid organs.

Dr. Zein is actively involved in the education of fellows and residents being trained at the Cleveland Clinic.  He has been recognized by the Cleveland Clinic Lerner College of Medicine Teacher of the Year, a distinction that reflects his commitment to the education and mentorship of young physicians.

Dr Zein has served as the Editor of “The Year in Gastroenterology and Hepatology” associate editor of the American Journal of Gastroenterology, Special Section Editor of “Liver Transplantation” and an editorial board member of Hepatology and Gastroenterology & Hepatology.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Mayo Clinic
Adult & Pediatric Gastroentero
Rochester, MN USA

Residency - Medical College of Ohio Hospitals
Internal Medicine/Pediatrics
Toledo, OH USA

Internship - Medical College of Ohio Hospitals
Internal Medicine/Pediatrics
Toledo, OH USA

Medical Education - MetroHealth Medical Center
Cleveland, OH USA

Medical Education - Tishreen University Faculty of Medicine
Lattakia, Syria

Additional Training

  • Mayo Clinic Scholar 1996-1997

Professional Highlights

  • Chairman, Global Patient Services
  • Mikati Foundation Endowed Chair in Liver Diseases and Transplantation

Specialty Interests

Liver disease, liver transplantation, cirrhosis, hepatitis B, hepatitis C, nonalcoholic fatty liver disease, portal hypertension, Wilson's disease, hemochromatosis, autoimmune hepatitis, cholangitis, Budd Chiari, diagnostic and therapeutic EGD (upper endoscopy) and colonoscopy. Medical school education.

Awards & Honors

  • Medical College of Ohio most outstanding resident award 1992
  • Mayo Clinic J Arnold Bargen Award for outstanding achievement in Gastroenterology training 1996
  • American Liver Foundation Scholar Award 1997
  • Innovator Award, Cleveland Clinic 2004
  • Physician of the Year, Cleveland Clinic International Center 2005
  • Innovator Award, cleveland Clinic 2006
  • Academic Achievement Award, Syrian American Medical Society 2007
  • Mikati Foundation Endowed Chair in Liver Diseases and Transplantation 2007
  • Top Doctors in Cleveland, Cleveland Magazine 2007
  • Teacher of the year, Cleveland Clinic 2008

Innovations & Patents

  • NS5 and Core proteins in inducing protective antibodies, MMV # 99-073
  • Inhaled liposomal IL-2 in the treatment of chronic HCV infection, MMV # 01-022
  • Etanercept as an adjuvant to interferon and ribavirin for patients with chronic hepatitis C infection, MMV # 03-07
  • A novel assay using ascetic fluid Lactoferrin to diagnose spontaneous bacterial peritonitis and other bacterial infections in patients with liver cirrhosis (CCF, 2004)
  • Non-invasive diagnostic test (serum cytokeratin-18) for patients with suspected nonalcoholic fatty liver disease (serial # 60/801,728)


  • American College of Gastroenterology
  • American Gastroenterology Association
  • American Association for the Study of Liver Diseases
  • Syrian-American Medical Society
Research & Publications

Research & Publications

See publications for Nizar Zein, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 8/7/2020, Dr. Zein has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

39 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.7 out of 5
Explains 4.7
Courtesy, Respect & Concern 4.8
Patient Rating of Doctor 4.7

9 Patient Comments

Reviewed on Jul 30, 2020

Love Dr Zein. we live an hour away, and there are doctors locally and we choose to come to Cleveland to see him.

Reviewed on Jul 2, 2020

Dr. Zein and Dr Andrews are always informative and ready to listen to any concerns that I have. I always know that I am in excellent care.

Reviewed on Jun 25, 2020

Dr. Zein answered all my questions completely.

Reviewed on Jun 11, 2020

I did not realize *Dr. Zein only did procedures but was not a Crohn's physician - so I need to find one at the clinic (I previously had *Dr. Shen). My colonoscopy was somewhat painful as I was only mildly sedated - I have never had a problem w/twilight sedation before and would have preferred it this time too.

Reviewed on May 7, 2020

Dr. Zein went out of his way to see me about 3 hours early.

Reviewed on May 7, 2020

Dr. Zein is without doubt the best physician I have ever had in my 72 years of living. I honestly believe his knowledge, professionalism and kindness has enabled me to be in the best health I could possibly be in. I am blessed to have him as my doctor.

Reviewed on Mar 12, 2020

Dr. Zein explained my health concerns completely. He gave me a thorough explanation of my diagnosis until I completely understood. He is highly professional and kind. He is one of the best doctors that I ever have had.

Reviewed on Nov 7, 2019

The staff was very fast and courteous and efficient. I have never seen Dr Zein and was so worried and he was so calm and Awesome!

Reviewed on Oct 31, 2019

Dr Zein is very professional and friendly. I have complete confidence in him.

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