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Department Infectious Disease
Primary Location Medical Office Building and Surgery Center, Stuart
Type of Doctor Adults Only
Languages English, Spanish
Surgeon No
Primary Location

Medical Office Building and Surgery Center, Stuart

Specialties & Treatments

Treatment & Services

  • Clinical Trials
  • Infectious Disease Consultation
  • Infectious Disease Treatment
  • International Travel Related Preparation
  • Outpatient Antibiotic Therapy
  • Second Opinion
  • Travel Vaccines
View all 7 Treatment & Services +

Specialty in Diseases & Conditions

  • Bacteremia
  • Bone Infection
  • Bone Marrow Transplant Related Infections
  • Breast Infections
  • Cardiac Device Infections
  • Cardiac Implantable Electronic Device Infection
  • Cellulitis
  • Chlamydia Trachomatis
  • Defibrillator Infections
  • Encephalitis
  • Endocarditis
  • Fever
  • Fever in Transplant Recipients
  • Fungal Infections
  • General Infectious Diseases
  • General Infectious Transplant
  • General Outpatient Infectious Disease
  • Giardiasis
  • Gonorrhea
  • Herpes
  • Histoplasmosis
  • Hospital Acquired Infections
  • Infections in Leukemia and Oncology Patients
  • Infective Endocarditis
  • International Travel Related Diseases
  • Joint Infection
  • Kidney Infections
  • Meningitis
  • Methicillin-Resistant Staphylococcus Aureus (MRSA)
  • Mycobacterial Infections
  • Mycobacterium Avium Complex
  • Neurologic Infections
  • Non-Tuberculosis Mycobacteria (ASB)
  • Prosthetic Joint Infections
  • Sepsis
  • Solid Organ Transplant Related Infections
  • Spinal Infections
  • Staphylococcus Aureus Infections
  • Surgical Site Infections
  • Syphilis
  • Transplant Infections
  • Tropical Diseases
  • Tuberculosis
  • Ventricular Shunt Infections
View all 44 Specialties +


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About Lyssette Cardona, MD

Lyssette L. Cardona, MD, MPH, MSHA, FIDSA has been on Staff in the Department of Infectious Diseases Medicine at Cleveland Clinic Florida in Weston, Fla., since 2002. She was appointed Department Chair until 2014 when she joined Cleveland Clinic Abu Dhabi to pioneer  the inaugural Infectious Diseases, Infection Control and Occupational Health Departments. In 2017 she was named Chair for the Caregiver Wellbeing Division where she led an innovative and holistic program focused on caregiver occupational health & wellness until December 2020. Dr. Cardona relocated back to Cleveland Clinic Florida in January 2021 to build the Infectious Diseases Department at Martin Health, and the Occupational Health & Wellness Departments for Cleveland Clinic Martin Health and Cleveland Clinic Indian River Hospital. Her specialty interests are in bone-joint infections, mycobacterial infections, travel medicine, general infectious diseases, outpatient antimicrobial therapy and quality in healthcare. She is very passionate about workplace safety, health and workforce well-being. 

Dr. Cardona received her BS in biology from the University of Puerto Rico, Mayaguez, in 1979. She then completed an MPH in epidemiology at Tulane School of Public Health and Tropical Medicine in New Orleans, La. Dr. Cardona earned her medical degree from the University of Puerto Rico Medical School in Rio Piedras in 1983. She completed an internship in internal medicine and residencies in internal medicine and preventive medicine, followed by an infectious disease fellowship, at Tulane University Medical Hospital in New Orleans. Additionally, she completed an MS in health administration at Barry University in Miami, Fla., in 2005. The Infectious Diseases Society inducted Dr. Cardona as a Fellow in 2009 and she remains active as a taskforce member of the Leadership Institute.

Her professional experience includes working as Infectious Disease Consultant and Director of AIDS Research Protocols for the Keith Medical Practice Group in Los Angeles, Calif., from 1989 to 1993. She also worked in private practice in internal medicine and infectious disease in Los Angeles during that time. After that, she was Medical Director of the Los Angeles Immune Suppressed/AIDS Unit of the Medical Center of North Hollywood in North Hollywood, Calif (1993-1995). She was Infectious Disease Consultant for the Pacific Oaks Medical Group and Medical Director of the Pacific Oaks Women's Education and Resource Center for HIV in 1994-1995.

From 1995-2002, she served as Infectious Disease Consultant for the Friedberg Medical Group in Ft. Lauderdale, Fla., and Infectious Disease Consultant for Travel Medicine for Weston International Clinic in Weston, Fla. In 2002, she was appointed to Staff in the Department of Infectious Diseases at Cleveland Clinic Florida. From 2014-2020, she was seconded to serve as Department Chair of Infectious Diseases and Occupational Health at Cleveland Clinic Abu Dhabi in the United Arab Emirates.

Presently, she is Chair of the Department of Infectious Diseases at Cleveland Clinic Martin Florida under the Medical Specialties Institute. In addition, she is Chair of the Department of Occupational Health and Wellness for Cleveland Clinic Martin Health and Cleveland Clinic Indian River Hospital.

Dr. Cardona is certified by the American Board of Internal Medicine with subspecialty certification in infectious diseases. Dr. Cardona was certified in risk management by the AHCA, Florida, in 2006. She is currently licensed to practice in the state of Florida.

Education & Professional Highlights

Education & Professional Highlights


Additional Training

  • TB/NTM Denver Course, National Jewish Health, 2013
  • Board-certified, American Academy HIV Medicine, 2005-Present
  • Florida Risk Management Institute, licensed Risk Manager, AHCA, 2006
  • International HIV Physician Mentor Certification, 2006
  • Master's in Health Services Administration, Barry University, Fla., 2005

Professional Highlights

  • AMA CPT E/M Task Force IDSA Representative,2013-4
  • Broward County Medical Association, Women's Task Force,Co-Chair, 2013-14
  • Education Committee,Quality Task Force Member, ID Society of America , 2009-present
  • Clinical Affairs Committee, Member, ID Society of America , 2009-12
  • HIV/ID MOC Program, Member & Reviewer, ABIM/IDSA , 2010-11,2014
  • Staph aureus Metrics(SAM) Task Force, ID Society of America, 2012-2014
  • ID Society of America, Fellow
  • Department Chair, Infectious Diseases, Cleveland Clinic Florida, 2008–Present
  • Chair, Infection Control, 2006–2013
  • Chair, CME Committee, Cleveland Clinic Florida,2010-2014
  • Co-Chair, CME Committee, Cleveland Clinic Florida, 2005–2010
  • Employee Health Medical Director, Cleveland Clinic Florida, 2005–2013
  • Florida Board Member, American Academy HIV Medicine, 2005–2012
  • Chair,Founding Member, Women's Professional Staff Association,Cleveland Clinic Florida, 2005–2014


  • Internal Medicine - Infectious Disease
  • Internal Medicine

Specialty Interests

HIV/AIDS, bone and joint infections, mycobacterial infections, international travel health, C. difficile, STDs, healthcare and quality in infectious diseases and preventative medicine

Awards & Honors

  • 100 Outstanding Women of Broward County, Honoree, Florida, 2014
  • Women's Professional Staff Association Achievement Awards,Cleveland Clinic Florida 2007, 2008, 2010, 2012
  • Castle Connolly List, Top Doctor in South Florida, Infectious Diseases, 2012,2013,2014
  • Women of Merit, International Business Women Association, Weston, Fla., 2008
  • Physician of the Year, Cleveland Clinic Florida WPSA, 2007, 2012
  • Certificate of Appreciation, Hospice by the Sea, 2006
  • Ritter Foundation Merit Scholarships, Barry University, Miami, Fla., 2003–2004
  • Doctor Congeniality, Cleveland Clinic Hospital, Florida, 2003
  • Physician of the Month, Cleveland Clinic Hospital, Florida, December 2002
  • Alpha Omega Alpha Honors Society, Elected 1983
  • Outstanding Graduate, Medical Class of 1983, Puerto Rico
  • Tulane Musser-Burch Honor Society, Elected August 1983, New Orleans, La.
  • Who’s Who of New Orleans, Award of Achievement, 1993
  • Women of Achievement Award, Tri-Valley Professional Business Clubs, Los Angeles, Calif., 1993
  • POMG Commendation/AIDS Services Award, Mayor of Los Angeles, 1994
  • Nuestros Recuerdos, AIDS Community Service Award, 1994


  • IDSA, AAHIVS, AMA, Broward County Medical Association, Transplant Society, APIC, SHEA, ASM
Research & Publications

Research & Publications

See publications for Lyssette Cardona, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 2/7/2024, Dr. Cardona has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

37 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.8 out of 5
Explains 4.8
Courtesy, Respect & Concern 4.8
Patient Rating of Doctor 4.8

0 Patient Comments

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