Carrie Hersh, DO

Appointed
2015

Education & Fellowships

Graduate School - Case Western Reserve University School of Medicine
Clinical Research
Cleveland, OH USA
2016

Fellowship - Cleveland Clinic
Neuroimmunology
Cleveland, OH USA
2015

Residency - Cleveland Clinic
Neurology
Cleveland, OH USA
2013

Internship - Cleveland Clinic
Internal Medicine
Cleveland, OH USA
2010

Medical Education - Nova Southeastern University
Davie, FL USA
2009

Undergraduate - University of Florida
Gainesville, FL USA
2005

Additional Training

Professional Highlights

• Peer Reviewed Publications:

  Hersh, CM. The effects of environmental challenges on nociception/orphanin FQ-induced anxiety. J Undergrad Res. 2005; 6(7). http://ufdc.ufl.edu/UF00091523/00330/1j.
• Hersh, C, Rae-Grant, A. Extended-release dalfampridine in the management of MS-related walking impairment. Ther Adv Neurol Disord. 2012; 5(4):199-204. doi: 10.1177/1756285612447091. PMID: 22783369.
• Hersh, CM, Cohen, JA. Alemtuzumab for the treatment of relapsing-remitting multiple sclerosis. Immunotherapy. 2014; 6(3): 249-259. doi: 10.2217/imt.14.7. PMID: 24762071.
• Hersh, CM, Hara-Cleaver, C, Rudick, RA, Cohen, JA, Bermel, RA, Ontaneda, D. Experience with fingolimod in clinical practice. Int J Neurosci. 2015; 125(9):678-85. doi: 10.3109/00207454.2014.969839. PMID: 25271798.
• Hersh, CM, Love, TE, Cohn, S, Hara-Cleaver, C, Bermel, RA, Fox, RJ, Cohen, JA, Ontaneda, D. Comparative efficacy and discontinuation of dimethyl fumarate and fingolimod in clinical practice at 12-month follow-up. Mult Scler Relat Disord. 2016 Nov; 10:44-52. doi: 10.1016/j.msard.2016.08.002. PMID: 27919497.
• Hersh, CM, John, S, Subei, A, Willis, MA, Kosmorsky, G, Prayson, RA, Bhimraj, A. Optic neuropathy and stroke secondary to invasive Aspergillus in an immunocompetent patient. J Neuroophthalmol. 2016 Dec; 36(4):404-407. doi: 10.1097/WNO.0000000000000361. PMID: 27031126.
• Hersh, CM, Love, TE, Bandyopadhyay, A, Cohn, S, Hara-Cleaver, C, Bermel, RA, Fox, RJ, Cohen, JA, Ontaneda, D. Comparative efficacy and discontinuation of dimethyl fumarate and fingolimod in clinical practice at 24-month follow-up. Mult Scler J Exp Transl Clin. 2017 Aug; 3(3):2055217317715485. doi: 10.1177/2055217317715485. PMID: 28890796.
• Moss, B, Rensel, MR, Hersh, CM. Wellness and the role of comorbidities in multiple sclerosis. Neurotherapeutics. 2017 Oct; 14(4):999-1017. doi: 10.1007/s13311-017-0563-6. PMID: 28785958.
• Vollmer, B, Ontaneda D, Bandyopadhyay, A, Cohn, S, Nair, K, Sillau, S, Bermel, R, Corboy, J, Fox, RJ, Vollmer, T, Cohen, JA, Alvarez, A, Hersh, CM. Discontinuation and comparative effectiveness of dimethyl fumarate and fingolimod in two centers. Neurol Clin Pract. 2018 Aug; 8(4):292-301. doi: 10.1212/CPJ.0000000000000487. PMID: 30140580.
• Hua, LH, Hersh, CM, Morten, P, Kusel, J, Lin, F, Cave, J, Varga, S, Herrera, V, Ko, J. The impact of price reductions after loss of exclusivity in a cost-effective analysis: fingolimod versus intramuscularly-administered interferon beta-1a for the treatment of relapsing forms of multiple sclerosis. J Manag Care Spec Pharm. 2019 Apr; 25(4):490-498. doi: 10.18553/jmcp.2019.25.4.490. PMID: 30917079.
• Vollmer, B, Ontaneda, D, Harris, H, Nair, K, Bermel, R, Corboy, J, Fox, RJ, Vollmer, T, Cohen, JA, Alvarez, A, Hersh, CM. Comparative discontinuation, effectiveness, and switching practices of dimethyl fumarate and fingolimod at 36-month follow-up. J Neurol Sci. 2019 Dec 15; 407:116498. doi:10.1016/j.jns.2019.116498. PMID: 31644992.
• Conway, DS, Hersh, CM, Harris, HC, Hua, LH. Duration of natalizumab therapy and reasons for discontinuation in a multiple sclerosis population. Mult Scler J Exp Transl Clin. 2020 Jan 27; 6(1): 2055217320902488. doi: 10.1177/2055217320902488. PMID: 32064117.
• Hua, LH, Harris, H, Conway, D, Hersh, CM. Disease activity outcomes with different washout periods after switching from natalizumab to an alternative disease-modifying therapy. J Neurol. 2020 Aug;267(8):2214-2220. doi: 10.1007/s00415-020-09816-1. PMID: 32270292.
• Ontaneda, D, Tallantyre, EC, Raza, PC, Planchon, S, Nakamura, K, Miller, D, Hersh, C, Craner, M, Bale, C, Chaudhry, B, Gunzler, DD, Love, TE, Gerry, S, Coles, A, Cohen, JA, Evangelou, N. Determining the effectiveness of early intensive versus escalation approaches for the treatment of relapsing-remitting multiple sclerosis: The DELIVER-MS study protocol. Contemp Clin Trials. 2020 Aug;95:106009. doi: 10.1016/j.cct.2020.106009. PMID: 32320842.
• Hauser SL, Bar-Or A, Cohen JA, Comi G, Correale J, Coyle PK, Cross AH, de Seze J, Leppert D, Montalban X, Selmaj K, Wiendl H, Kerloeguen C, Willi R, Li B, Kakarieka A, Tomic D, Goodyear A, Pingili R, Häring DA, Ramanathan K, Merschhemke M, Kappos L; ASCLEPIOS I and ASCLEPIOS II Trial Groups and Clinical Investigators: Hersh, C (I did not work closely with any of the listed authors on this publication). Ofatumumab versus teriflunomide in multiple sclerosis. N Engl J Med. 2020 Aug 6;383(6):546-557. doi: 10.1056/NEJMoa1917246.N Engl J Med. 2020. PMID: 32757523.
• Mowry, E, Bermel, RA, Williams, JR, Benzinger, T, de Moor, C, Fisher, E, Hersh, CM, Hyland, MH, Izbudak, I, Jones, SE, Kieseier, BC, Kitzler HH, Krupp, L, Lui, YW, Montalban, X, Naismith, RT, Nicholas,, JA, Pellegrini, F, Rovira, A, Schulze, M, Tackenberg, B, Tintore, M, Tivarus, ME, Ziemssen, T, Rudick, RA. Harnessing real-world data to inform decision-making: multiple sclerosis partners advancing technology and health solutions (MS PATHS). Front Neurol. 2020 Aug 7;11:632. doi: 10.3389/fneur.2020.00632. PMID: 32849170.
• Hersh, CM, Harris, H, Ayers, M, Conway, D. Effect of tobacco use on disease activity and DMT discontinuation in multiple sclerosis patients treated with dimethyl fumarate or fingolimod. Mult Scler J Exp Transl Clin. 2020 Oct 13;6(4):2055217320959815. doi: 10.1177/2055217320959815. PMID: 33110616.
• Hua, LH, Hersh, CM, Tian, F, Mowry, EM, Fitzgerald, KC. Clinical characteristics of a large multi-center cohort of people with multiple sclerosis over age 60. Mult Scler Relat Disord. 2020 Nov 23;47:102637. doi: 10.1016/j.msard.2020.102637. PMID: 33276238.
• Hersh, CM, Harris, H, Conway, D, Hua, LH. Impact of switching from natalizumab to moderate versus high efficacy DMT in clinical practice. Neurol Clin Pract. 2020 Dec 10 (6) e53-e65; doi: 10.1212/CPJ.0000000000000809. PMID: 33510948. Received “Notable This Week” and “Most Read Article” designations.
• Morrison-Banks, E, Michtich, K, Hersh, CM. How the COVID-19 pandemic has changed multiple sclerosis clinical practice: results of a nationwide provider survey. Mult Scler Relat Disord. 2021 Mar 18;51:102913. doi: 10.1016/j.msard.2021.102913. PMID: 33839482.
• Hersh, CM, Brook, RA, Beren, IA, Rohrbacker, NJ, Lebson, L, Henke, C, Phillips, A. The implications of suboptimal treatment outcomes with disease-modifying drugs in employees with multiple sclerosis. J Med Econ. 2021 Mar 19;24:1:479-486.doi: 10.1080/13696998.2021.1906013. PMID: 33739915.
• Hersh, CM, Kieseier, B, deMoor, C, Miller, D, Campagnolo, D, Williams, JR, Fitzgerald, K, Xiong, K, McGinley, M, Hyland, M, Ruddick, R, Ziemssen, T, Koulinska, I. Impact of natalizumab on quality of life in a real-world cohort of patients with multiple sclerosis: results of MS PATHS. 2021 Apr 15;7(2). doi: 10.1177/20552173211004634.
• Ziemssen, T, Giovannoni, G, Alvarez, E, Bhan, V, Hersh, C, Hoffman, O, Oreja-Guevara, C, Robles-Cedeno, R, Trojano, M, Vermersch, P, Dobay, P, Khwaja, M, Stadler, B, Rauser, B, Hach, T, Piani-Meier, D, Burton, J. MSProDiscussTM, a useful digital tool to evaluate early signs of multiple sclerosis disease progression in a real world setting. J Med Internet Res. J Med Internet Res. 2021 Oct 6;23(10):e29558. doi: 10.2196/29558. PMID: 34612826.
• Cohen, JA, Bermel, RA, Grossman, CI, Hersh, CM, Hyland, H, Mowry, EM, Naismith, R, Naylor, ML, Nicholas, J, Rajbhandari, R, Singh, CM, Tintorè, M, Zabalza, A, Ziemssen, T, Williams, JR, Montalban, X, on behalf of the MS PATHS Investigators. IgG Immune response to SARS-CoV-2 vaccination in people living with multiple sclerosis within MS PATHS. Mult Scler. 2022 Jan 7;13524585211061343. doi: 10.1177/13524585211061343. PMID: 34994577.
• Hersh, CM, Altincatal, A, Kapadia, S, de Moor, C, Rudick, R, Williams, JR, Miller, C, Koulinska, I. Real-world effectiveness of dimethyl fumarate versus fingolimod in a cohort of patients with multiple sclerosis using standardized, quantitative outcome metrics. Mult Scler J Exp Transl Clin. 2022 Jan 7;8(1):20552173211069852. doi: 10.1177/20552173211069852. PMID: 35024161.
• Foley JF, Defer G, Ryerson LZ, Cohen JA, Arnold DL, Butzkueven H, Cutter G, Giovannoni G, Killestein J, Wiendl H, Smirnakis K, Xiao S, Kong G, Kuhelj R, Campbell N; NOVA study investigators. Comparison of switching to 6-week dosing of natalizumab versus continuing with 4-week dosing in patients with relapsing-remitting multiple sclerosis (NOVA): a randomised, controlled, open-label, phase 3b trial: Hersh, CM. Lancet Neurol. 2022 Apr 25:S1474-4422(22)00143-0. doi: 10.1016/S1474-4422(22)00143-0. Epub ahead of print. PMID: 35483387.
• Conway DS, Briggs FB, Mowry EM, Fitzgerald KC, Hersh, CM. Racial disparities in hypertension management among multiple sclerosis patients. Mult Scler Relat Disord. 2022 Jun 15;64:103972. doi: 10.1016/j.msard.2022.103972. Epub ahead of print. PMID: 35728435.
• Amin, M and Hersh, CM. Updates and advances in multiple sclerosis neurotherapeutics. Neurodegener Dis Manag. 2022 Oct 31. doi: 10.2217/nmt-2021-0058. Epub ahead of print. PMID: 36314777.
• Sotirchos, ES, Fitzgerald, KC, Singh, CM, Smith, MD, Reyes-Mantilla, M, Hersh, CM, Hyland, MH, Canissario, R, Simmons, S, Arrambide, G, Montalban, X, Comabella, M, Naismith, RT, Krupp, LB, Nicholas, JA, Ziemssen, T, Rudick, R, Fisher, E, Bermel, RA, Mowry, EM, Calabresi, PA. Associations of serum neurofilament light chain with clinical characteristics and radiological measures in a large real world MS population. Ann Clin Transl Neurol. 2022 Nov 25. doi: 10.1002/acn3.51704. Epub ahead of print. PMID: 36427295.
• Sullivan, AB, Hersh, CM, Rensel, R, Benzil, D. Leadership inequity, burnout and lower engagement of women in medicine. J Health Serv Psychol. 2023. https://doi.org/10.1007/s42843-023-00078-9.
• Hersh, CM, Morrow, SA, Williams, MJ, Amezcua, L, Halper, J, Wandersee, K. Diversity, Equity, and Inclusion in the Multiple Sclerosis Community: A Call to Action. Int J MS Care. 2023 May 23. https://doi.org/10.7224/1537-2073.2023-039.
• Sotirchos, ES, Hu, C, Smith, MD, Lord, H, DuVal, A, Arrambide, G, Montalban, X, Akguen, K, Ziemssen, T,  Naismith, RT, Hersh, CM, Hyland, MH, Krupp, LB, Nicholas, JA, Bermel, RA, Mowry, EM, Calabresi, PA, Fitzgerald, KC. Agreement between reference resources for blood neurofilament light chain levels in people with multiple sclerosis. Neurology. 2023 Oct 10:10.1212/WNL.0000000000207957. doi: 10.1212/WNL.0000000000207957. Epub ahead of print. PMID: 37816633.
• Alvarez, E, Longbrake, EE, Rammohan, K, Stankiewicz, J, Hersh, CM. Secondary hypogammaglobulinemia in patients with multiple sclerosis on anti-CD20 therapy: pathogenesis, risk of infection, and disease management. Mult Scler Relat Disord. 2023 Sep 15;79:105009. doi: 10.1016/j.msard.2023.105009. Epub ahead of print. PMID: 37783194.
• Hersh, CM. Contemporary topics in multiple sclerosis. Neurol Clin. 2024 Feb;42(1):xiii-xv. doi: 10.1016/j.ncl.2023.08.001. Epub 2023 Aug 26. PMID: 37980125.
• Aboseif, A, Roos, I, Krieger, S, Kalincik, T, Hersh, CM. Leveraging real world evidence and observational studies in treating multiple sclerosis. Neurol Clin. 2024 Feb;42(1):203-227. doi: 10.1016/j.ncl.2023.06.003. Epub 2023 Jul 21. PMID: 37980116.

Certifications

• Psychiatry and Neurology - Neurology

Awards & Honors

• 2001 University of Florida Honors Program
• 2002 Phi Eta Sigma Honor Society, UF
• 2002 National Society of Collegiate Scholars
• 2002 Golden Key International Honor Society, UF
• 2004 National Dean’s List
• 2004 National Society of Collegiate Scholars Merit Award, UF
• 2004 Presidential Recognition, UF
• 2004 Chancellor’s List, UF
• 2004 University Scholars Program, UF
• 2004 Phi Kappa Phi Honor Society, UF
• 2004 Phi Beta Kappa, UF
• 2005-2009 Dean’s List, NSU
• 2006 Sigma Sigma Phi Honor Society, NSU
• 2009 Psi Sigma Alpha National Osteopathic Honor Society, NSU
• 2012 7^th Annual MASTER MS Fellowship Program
• 2014 Consortium of MS Centers (CMSC) Scholarship Award
• 2015 American Academy of Neurology (AAN) Fellows Scholarship Award
• 2015 Neurological Institute Research Day Clinical Fellow Award, CCF
• 2016 Travel Grant Award, European Committee for Treatment and Research in MS (ECTRIMS) 2016
• 2016 Top Score Poster, ECTRIMS 2016
• 2016 Top Score Poster, ECTRIMS 2016
• 2016 Editor’s Choice for original research, Multiple Sclerosis and Related Disorders journal article “Comparative efficacy and discontinuation of dimethyl fumarate andfingolimod in clinical practice at 12-month follow-up”
• 2017 Travel Grant Award, ECTRIMS 2017
• 2018 Healthcare Headliner Award in Research/Science, Vegas Inc.
• 2018 Top Score Poster, ECTRIMS 2018
• 2019 Top Score Poster, ECTRIMS 2019
• 2020 Fellow of the American Academy of Neurology (FAAN)

Innovations & Patents

Memberships

• Consortium of Multiple Sclerosis Centers
• National Multiple Sclerosis Society
• Multiple Sclerosis Association of America
• American Academy of Neurology

See publications for Carrie Hersh, DO.

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Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 7/24/2023, Dr. Hersh has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Hersh receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

• Biogen Idec, Inc.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.