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Department Cardiovascular Medicine
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Treatment & Services

  • Abnormal Stress Test
  • Adult General Clinical Cardiology
  • Cardiology
  • Cardiovascular Medicine
  • Cardiovascular Medicine Department
  • Clinical Cardiology Section
  • General Cardiology
View all 7 Treatment & Services +

Specialty in Diseases & Conditions

  • Abnormal Heart Rhythms
  • Aorta Disease
  • Aortic Occlusion (Blockage)
  • Aortic Regurgitation
  • Aortic Stenosis
  • Aortic Valve Regurgitation
  • Arteriosclerosis Obliterans
  • Asymptomatic Valve Dysfunction
  • Atrial Fibrillation
  • Atrial Flutter
  • Cardiomyopathy
  • Cardiovascular Disease
  • Constrictive-Pericarditis
  • Coronary Artery Disease
  • Diastolic Dysfunction
  • Dilated Cardiomyopathy
  • Dyspnea
  • Heart Attack
  • Heart Disease
  • Heart Failure
  • Heart Murmur
  • Heart Valve Disease
  • High Blood Pressure (Hypertension)
  • High Cholesterol
  • Hypertrophic Cardiomyopathy
  • Ischemic Cardiomyopathy
  • Mitral Valve Prolapse
  • Mitral Valve Regurgitation
  • Mitral Valve Stenosis
  • Myocardial Ischemia
  • Pericardial Effusion
  • Pericarditis
  • Rheumatic Heart Disease
  • Shortness of Breath
View all 34 Specialties +


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About Umesh N. Khot, MD

Umesh N. Khot, MD, is a Vice Chairman of the Robert and Suzanne Tomsich Department of Cardiovascular Medicine, the Director of Regional Cardiovascular Medicine, and the Heart, Vascular and Thoracic Institute Chief Compliance Officer. He is a staff cardiologist in the Section of Clinical Cardiology in the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute. His clinical specialties include coronary artery disease, heart attack care, heart valve disease and heart failure. He is board-certified in cardiovascular medicine and echocardiography.

A graduate of The Ohio State University College of Medicine, Dr. Khot completed a residency in internal medicine at Stanford University Medical Center followed by a fellowship in cardiovascular medicine at Cleveland Clinic. He was appointed to the medical staff in 2011.

Prior to his appointment to the Cleveland Clinic staff, Dr. Khot was director of the Noninvasive Vascular Laboratory with Indiana Heart Physicians and director of the EHART® STEMI Program at St. Francis Heart Center in Indianapolis. He also was a member of the Practice Executive Committee and a member of the St. Francis Heart Center Cardiac Operations Group. EHART® is a specialized triage and treatment protocol developed by Dr. Khot to reduce the time-to-treatment for heart attack patients who come to the emergency room. This protocol has led not only to improved time-to-treatment but also to an increased rate of survival after the heart attack. The American Heart Association and the American College of Cardiology have recognized this protocol as a major advance in heart attack care.

Dr. Khot is a world expert in the design of heart attack systems of care with his work being highlighted by multiple medical journals and the American Heart Association and the American College of Cardiology. He also has extensive experience in healthcare information technology, clinical operations, and financial management of complex healthcare systems. His work has been awarded the HIMSS Davies Award for best information technology project nationally, the State of Ohio Patient Safety Institute Best Practice Award, and the Best Achievement of Operational Excellence in Healthcare.

Dr. Khot is the author of a number of research articles in leading medical journals, including The New England Journal of Medicine, Journal of the American Medical Association (JAMA), Journal of the American College of Cardiology and Circulation. He has contributed to novel understanding of the role of vasodilator therapy in severe aortic stenosis, the association between risk factors and heart disease, and insights into outcomes in patients with myocardial infarction, heart failure, and heart surgery. His research has been cited within the practice guidelines of the American College of Cardiology, American Heart Association, and European Society of Cardiology. Dr. Khot has been a reviewer for JAMA, Circulation, American Heart Journal, Nature Practice Cardiovascular Medicine and American Journal of Cardiology. He is a Fellow of the American College of Cardiology. 

 Dr. Khot enjoys spending time with his four children, traveling, and exploring the outdoors.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Graduate School - Harvard University
Healthcare Management
Cambridge, MA USA

Fellowship - Cleveland Clinic
Cardiovascular Medicine
Cleveland, OH USA

Residency - Stanford University
Internal Medicine
Stanford, CA USA

Medical Education - The Ohio State University College of Medicine and Public Health
Columbus, OH USA

Undergraduate - Northwestern University
Evanston, IL USA


  • Internal Medicine - Cardiovascular Disease

Specialty Interests

General cardiology, heart disease, nuclear imaging - heart, clinical cardiology, heart attack, heart valve disease, echocardiogram, cardiac catheterization

Awards & Honors

  • Patient Safety Hero Award, Indianapolis Coalition for Patient Safety (2007)
  • Tony and Mary Hulman Health Achievement Award, Indiana Public Health Foundation (2007)
  • Cleveland Clinic Tarazi Award for Cardiovascular Research (2002)
Research & Publications

Research & Publications

See publications for Umesh N. Khot, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 4/20/2023, Dr. Khot has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Royalty Payments. Dr. Khot receives or has the right to receive royalty payments for inventions or discoveries commercialized through the companies shown below:

  • Cardiac Protection Solutions, LLC

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

83 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 5
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

10 Patient Comments

Reviewed on Apr 10, 2024

Took one year to get in to see Dr. Khot.

Reviewed on Jan 31, 2024

Dr. Khot is great

Reviewed on Sep 20, 2023

Dr. Khot fit me into his schedule as soon as possible.

Reviewed on Sep 20, 2023

Dr. Khot shared all my information and test results with me, and explained the results in detail.

Reviewed on Sep 20, 2023

The Doctor was a very personable man to del with and I felt totally at ease when I left his office.

Reviewed on Aug 2, 2023

Dr. Khot is my most trusted physician and explains everything in detail to me and my family.

Reviewed on Jun 21, 2023

Eternally grateful to the Cleveland Cinic and it's providers for exceptional care.

Reviewed on Jun 21, 2023

Dr Khot is straight forward and realistic about issues which is appreciated

Reviewed on Jun 21, 2023

Dr Khot and assistant were very professional, kind and informative

Reviewed on May 22, 2023

Dr Vargo is a phenomenal surgeon and person

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