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Title Collection of Blood & Bone Marrow from Normal Volunteers & Patients for Research Purposes (No Funding)

IRB 5024

Hospital Beachwood, Fairview, Hillcrest, Independence, Main Campus, Mansfield, North Coast Cancer, South Pointe, Strongsville, Wooster

Disease Leukemia , Lymphoma, Peritoneal

Description

Trial Description Not Available

Inclusion Criteria

Normal volunteers and patients with hematologic disorders (adults and children) evaluated and/or treated at the Cleveland Clinic Foundation will be the source of blood, surgical specimen and bone marrow.The normal volunteers will be recruited through an advertisement flyer to be posted in appropriated boards throughout the institution or inter-institutional publications such as Innerpulse (see Appendix A). Patients include individuals with bone marrow failure syndromes, like aplastic anemia, paroxysmal nocturnal hemoglobinuria, myelodysplasia, Fanconi's anemia, and single lineage cytopenias.Patients with malignant disease include those with acute and chronic forms of leukemia including myeloproliferative disorders like mast cell diseases, multiple myeloma, myelofibrosis. Patients with constitutional anemias include patients with thalassemia, sickle cell disease, and all forms of lymphoma. Patients with immune-mediated processes include those with thrombocytopenic thrombotic purpura and idiopathic thrombocytopenic purpura.

Exclusion Criteria

Exclusion Criteria Not Available