High Blood Protein (Hyperproteinemia)

High protein in blood (hyperproteinemia) means you have abnormally high levels of protein in your blood plasma. If your blood protein levels are unusually high, a healthcare provider will order more tests to determine the condition or issue that caused your high blood protein levels.


What does it mean to have high protein in my blood?

Like its name, high protein in blood (hyperproteinemia) means the levels of protein in your blood plasma are higher than normal. Plasma is the liquid part of your blood. There are two main blood proteins — albumin and globulins:

  • Albumin: Your liver makes albumin protein. This protein keeps fluid from leaking from your blood vessels. It also helps enzymes, vitamins and other substances circulate throughout your body. A normal albumin range in an adult is 3.5 to 5.0 grams per deciliter (g/dl).
  • Globulins: Your liver and your immune system make globulins. This protein helps fight off infections. A normal globulin range in an adult is about 2.0 to 3.5 g/dl.

What are high blood protein symptoms?

High blood protein levels don’t cause symptoms. You may learn you have high blood protein if a healthcare provider orders a comprehensive metabolic panel. The results will show your total protein levels, albumin levels and the ratio of albumin to globulins, or A/G ratio. (A normal A/G ratio is 0.8 to 2.0.) If your blood protein levels are unusually high, a healthcare provider may order more tests, such as protein electrophoresis or total immunoglobulin levels.

Should I be worried if I have high blood protein?

No, you shouldn’t worry about a test result that shows your blood protein is higher than normal. Your test result doesn’t necessarily mean you have a serious illness. If your blood protein level is unusually high, your healthcare provider may order additional blood tests to get more information. They’ll also explain what may be causing a high blood protein level and what other tests they’ll order to identify the underlying condition.


Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Possible Causes

What causes high blood protein?

High blood protein levels are linked to several medical conditions and issues:

Care and Treatment

How do healthcare providers treat high blood protein?

High blood protein isn’t a medical condition. It’s a sign of an underlying issue. By treating the underlying issue, healthcare providers solve your blood protein problem.

Can I prevent high blood protein?

Many things may cause high blood protein levels, from dehydration to infections to certain blood cancers. In general, you can’t prevent all of the issues that may cause high blood protein.


Additional Common Questions

A blood test shows I have high blood protein. What should I do next?

If a test shows you have high blood protein, you should:

  • Make sure you get any additional tests your healthcare provider recommends.
  • Follow up with your healthcare provider. They may schedule additional appointments and tests so they can diagnose the issue causing high blood protein.

A note from Cleveland Clinic

It’s human nature to worry when medical tests show abnormal results. If a test shows you have high blood protein, you’re probably wondering why. You may worry that the test result means you could have a serious medical issue. If this is your situation, it’s important to remember a single blood test result isn’t a diagnosis. It’s a signal to your healthcare provider that there’s something going on in your body. If you have high blood protein, ask your healthcare provider to explain what your test results mean and what next steps they recommend.

Medically Reviewed

Last reviewed on 10/11/2022.

Learn more about our editorial process.

Cancer Answer Line 866.223.8100