Docusate Rectal Enema

Docusate is a laxative that treats occasional constipation. It comes in a small tube filled with liquid. You place the tip of the tube in your rectum and then release the medication. It works by softening your stool, making it easier to poop.

What is this medication?

DOCUSATE (doc CUE sayt) prevents and treats occasional constipation. It works by softening the stool, making it easier to have a bowel movement. It belongs to a group of medications called laxatives.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): DocuSol, Enemeez, VACUANT

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Nausea or vomiting
  • Severe constipation
  • Stomach pain
  • Sudden change in bowel habit lasting more than 2 weeks
  • An unusual or allergic reaction to docusate, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is for rectal use only. Do not take by mouth. Follow the directions on the label. Wash your hands before and after use. Remove tip from enema. Gently insert enema tip into the rectum. Squeeze tube until all the medication is inside the rectum. With the tube still squeezed, remove enema tip from the rectum. Do not use more often than directed.

Talk to your care team regarding the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

This does not apply; this medication is not for regular use.

What may interact with this medication?

  • Mineral oil

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Do not use for more than one week without advice from your care team. If your constipation returns, check with your care team.

Drink plenty of water while taking this medication. Drinking water helps decrease constipation.

Stop using this medication and contact your care team if you experience any rectal bleeding or do not have a bowel movement after use. These could be signs of a more serious condition.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Rectal pain, burning, or bleeding after use

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Diarrhea
  • Irritation at the application site
  • Stomach pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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