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Sevelamer Capsules or Tablets

Sevelamer is a medication that prevents increases in phosphates among people who are on dialysis due to chronic kidney disease. A phosphate is an essential substance in your body. This medication works by binding to phosphates in your stomach, which prevents your body from absorbing them.

What is this medication?

SEVELAMER (se VEL a mer) treats high phosphorus levels in people with kidney disease. It works by lowering the amount of phosphorus your body absorbs from food. It belongs to a group of medications called phosphate binders.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): RenaGel, Renvela

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Blockage in your bowel
  • Constipation
  • Difficulty swallowing
  • Stomach or intestine problems
  • An unusual or allergic reaction to sevelamer, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth with a glass of water. Take it as directed on the prescription label. Take it with food. Keep taking it unless your care team tells you to stop.

Talk to your pharmacist about when to take your medications. Some medications must be separated from this one by several hours.

Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 6 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

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What may interact with this medication?

This medication may interact with the following:

  • Ciprofloxacin
  • Cyclosporine
  • Mycophenolate
  • Levothyroxine
  • Tacrolimus

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

You may need blood work done while you are taking this medication.

You should make sure you get enough vitamins while you are taking this medication. Discuss the food you eat and the vitamins you take with your care team.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Bowel blockage—stomach cramping, unable to have a bowel movement or pass gas, loss of appetite, vomiting
  • Stomach bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Diarrhea
  • Gas
  • Nausea
  • Stomach pain
  • Upset stomach
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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