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Chlorpheniramine; Phenylephrine oral tablet

What is this medication?

CHLORPHENIRAMINE; PHENYLEPHRINE (klor fen IR a meen; fen il EF rin) is a combination of an antihistamine and a decongestant. It is used to treat symptoms of an allergy, cold, or sinus inflammation. It will help relieve runny nose, sneezing, and congestion in the nose. This medicine will not treat an infection.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Actifed Cold and Allergy, Allerest PE, ED A-HIST, ED-A-Hist, Giltuss-D Allergy & Congestion, Maxichlor PEH, NoHist, Phenagil, Sudafed PE Sinus and Allergy

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

•asthma

•diabetes

•glaucoma

•high blood pressure or heart disease

•prostate trouble

•thyroid disease

•trouble passing urine

•an unusual or allergic reaction to chlorpheniramine, phenylephrine, other medicines, foods, dyes, or preservatives

•pregnant or trying to get pregnant

•breast-feeding

How should I use this medication?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. If this medicine upsets your stomach, take with it with food. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Patients over 60 years old may have a stronger reaction and need a smaller dose.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medicine with any of the following medications:

•MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

This medicine may also interact with the following medications:

•any alcohol-containing product

•barbiturates like phenobarbital

•medicines for depression, anxiety, or psychotic disturbances

•medicines for sleep

•some medicines for cold, cough or allergy

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

•breathing problems

•blurred vision

•fast, irregular heartbeat

•fear, anxiety, restless, tremor

•hallucinations

•high or low blood pressure

•seizures

•trouble passing urine or change in the amount of urine

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

•dry mouth, nose, throat

•headache

•loss of appetite

•sleepy

•stomach upset, nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2024 Elsevier Inc. All Rights Reserved.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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