Locations:

Doxepin Solution

What is this medication?

DOXEPIN (DOX e pin) treats depression and anxiety. It increases the amount of serotonin and norepinephrine in the brain, hormones that help regulate mood. It belongs to a group of medications called tricyclic antidepressants (TCAs).

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Sinequan

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Bipolar disorder
  • Difficulty passing urine
  • Glaucoma
  • Heart disease
  • If you frequently drink alcohol containing drinks
  • Liver disease
  • Lung or breathing disease, like asthma or sleep apnea
  • Prostate trouble
  • Schizophrenia
  • Seizures
  • Suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member
  • An unusual or allergic reaction to doxepin, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth. Follow the directions on the prescription label. Shake well before using. Measure the correct amount of medication with the special dropper provided. Just before taking, dilute the solution with half a glass (4 oz.) of water, milk, or orange, grapefruit, tomato, prune or pineapple juice. Do not mix with a carbonated beverage or grape juice, they can stop the medication from working properly. Take your doses at regular intervals. Do not take your medication more often than directed. Do not stop taking this medication suddenly except upon the advice of your care team. Stopping this medication too quickly may cause serious side effects or your condition may worsen.

Advertisement

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. While this medication may be prescribed for children as young as 12 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

  • Arsenic trioxide
  • Certain medications used to regulate abnormal heartbeat or to treat other heart conditions
  • Cisapride
  • Halofantrine
  • Levomethadyl
  • Linezolid
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • Methylene blue
  • Other medications for mental depression
  • Phenothiazines like perphenazine, thioridazine and chlorpromazine
  • Pimozide
  • Procarbazine
  • Sparfloxacin
  • St. John's Wort

This medication may also interact with the following:

  • Cimetidine
  • Tolazamide
  • Ziprasidone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. It can take several days before you feel the full effect of this medication.

Patients and their families should watch out for worsening depression or thoughts of suicide. Also watch out for sudden or severe changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of antidepressant treatment or after a change in dose, call your care team.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may increase dizziness and drowsiness. Avoid alcoholic drinks.

Do not treat yourself for coughs, colds, or allergies without asking your care team for advice. Some ingredients can increase possible side effects.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.

Advertisement

This medication may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your care team if the problem does not go away or is severe.

This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Irritability, confusion, fast or irregular heartbeat, muscle stiffness, twitching muscles, sweating, high fever, seizure, chills, vomiting, diarrhea, which may be signs of serotonin syndrome
  • Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
  • Thoughts of suicide or self-harm, worsening mood, or feelings of depression
  • Trouble passing urine

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Change in sex drive or performance
  • Constipation
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Tremors
  • Weight gain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Advertisement

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Advertisement

Copyright ©2024 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

Ad
Call Appointment Center 866.320.4573
Questions 216.444.2200