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Clonidine Extended-Release Tablets (ADHD)

What is this medication?

CLONIDINE (KLOE ni deen) treats attention-deficit hyperactivity disorder (ADHD). It works by improving focus and reducing impulsive behavior.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Kapvay

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Bleeding in the brain
  • Heart disease
  • High or low blood pressure
  • History of slow or irregular heartbeat
  • Kidney disease
  • An unusual or allergic reaction to clonidine, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medication. You can take it with or without food. If it upsets your stomach, take it with food. Take your doses at regular intervals. Do not take your medication more often than directed. Do not suddenly stop taking this medication. You must gradually reduce the dose. Ask your care team for advice.

Talk to your care team regarding the use of this medication in children. While this medication may be prescribed for children as young as 6 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, skip the missed dose. Take the next dose at your regular time. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

This medication may also interact with the following:

  • Alcohol
  • Certain medications for seizures like phenobarbital
  • Certain medications for blood pressure, heart disease, irregular heart beat
  • Certain medications for depression, anxiety, or psychotic disturbances
  • Medications for sleep

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Check your heart rate and blood pressure regularly while you are taking this medication. Ask your care team what your heart rate should be and when you should contact them.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. To avoid dizzy or fainting spells, do not stand or sit up quickly. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

Avoid becoming dehydrated or overheated.

Do not stop taking except on your care team's advice. You may develop a severe reaction. Your care team will tell you how much medication to take.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water will help.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
  • Slow heartbeat—dizziness, feeling faint or lightheaded, confusion, trouble breathing, unusual weakness or fatigue

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Constipation
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Fatigue
  • Loss of appetite
  • Trouble sleeping

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2024 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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