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Tegaserod Tablets

What is this medication?

TEGASEROD (te GAS a rod) treats irritable bowel syndrome (IBS) with constipation. It works by helping the muscles in your intestines move stool. This helps produce a bowel movement.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Zelnorm

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Cigarette smoker
  • Depression
  • Diabetes
  • Gallbladder disease
  • Heart disease
  • High blood pressure
  • High cholesterol
  • History of stroke
  • Kidney disease
  • Liver disease
  • Now have diarrhea or have diarrhea often
  • Previous heart attack
  • Rectal bleeding
  • Stomach or intestine problems
  • Suicidal thoughts, plans or attempt by you or a family member
  • An unusual or allergic reaction to tegaserod, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth with water. Take it at least 30 minutes before meals. Take it as directed on the prescription label at the same time every day. Keep taking it unless your care team tells you to stop.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, skip it. Take your next dose at the normal time. Do not take extra or 2 doses at the same time to make up for the missed dose.

What may interact with this medication?

  • Medications for bowel problems or bladder incontinence (these can cause constipation)

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Diarrhea is a common side effect that usually happens in the first week of starting the medication. This will usually last only a few days and will not come back. You should not start taking this medication if you already have diarrhea or have diarrhea most of the time. Severe or prolonged diarrhea can lead to dehydration, a lack of fluids within your body. If you experience severe cramping, stomach pain, lightheadedness, dizziness or fainting accompanied by diarrhea, tell your care team immediately.

If you get new or worsening stomach pain with or without blood in your stools, call your care team right away.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
  • Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
  • Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
  • Sudden or severe stomach pain, bloody diarrhea, fever, nausea, vomiting
  • Thoughts of suicide or self-harm, worsening mood, feelings of depression

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Diarrhea
  • Dizziness
  • Gas
  • Headache
  • Nausea
  • Stomach pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 15 and 30 degrees C (59 and 86 degree F). Protect from heat and moisture. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

  • Take the medications to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If your cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, take the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2024 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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