Clinical Trials

What is a clinical trial?

In a clinical trial, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or changes to participants' behavior, such as diet. Clinical trials may compare a new medical approach to a standard one that is already available, to a placebo that contains no active ingredients, or to no intervention. Some clinical trials compare interventions that are already available to each other. When a new product or approach is being studied, it is not usually known whether it will be helpful, harmful, or no different than available alternatives (including no intervention). The investigators try to determine the safety and efficacy of the intervention by measuring certain outcomes in the participants. For example, investigators may give a drug or treatment to participants who have high blood pressure to see whether their blood pressure decreases.

Clinical trials used in drug development are sometimes described by phase. These phases are defined by the Food and Drug Administration (FDA).

Current Clinical Trials

Observational Trial to Evaluate Hematopoietic Stem Cell Transplantation CMV Reactivation (REACT)

Sponsor: Oxford Immunotec
Cleveland Clinic PI: Sherif Mossad, MD
Study Coordinator: Jackie Fox, RN
Clinicaltrials.gov 
Status: Open to enrollment

Safety and Efficacy of Fidaxomicin Versus Placebo for Prophylaxis Against Clostridium Difficile-Associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation (DEFLECT-1)

Sponsor: Merck Sharp & Dohme Corp.
Cleveland Clinic PI: Sherif Mossad, MD
Study Coordinator: Jackie Fox, RN
Clinicaltrials.gov
Status: Closed to enrollment

Study to Evaluate Efficacy, Safety, and Immunogenicity of GlaxoSmithKline (GSK) Biologicals’ Herpes Zoster Vaccine GSK1437173A

Sponsor: GlaxoSmithKline
Cleveland Clinic PI: Sherif Mossad, MD
Study Coordinator: Jackie Fox, RN
Clinicaltrials.gov 
Status: Closed to enrollment

Chronic Kidney Disease Knowledge and Awareness Among American Indians

Sponsor: Cleveland Clinic/National Institute of Diabetes and Digestive and Kidney Diseases
PI: Stacey Jolly, MD
Clinicaltrials.gov 
Status: Closed to enrollment