Services Accelerating Clinical Research

Scientific Core Services

Lerner Research Institute’s Scientific Core Services facilitate and advance Cleveland Clinic research by providing low-cost technologies that support basic, translational and clinical research. In 2021, the Scientific Core Services provided more than $12.4 million worth of services to internal researchers and $863 thousand worth of services to external researchers.

Some highlights from 2021 include:

  • The Center for Therapeutics Discovery synthesized more than 850 novel compounds to support tool compound generation and preclinical candidate selection for in-house collaborations and discovery therapeutics. Three 50K and four 8K high-throughput plate-based screening assays were performed, leading to newly identified chemical matter for hit-to-lead optimization.
  • The Engineering Design Core designed and built 96 anatomy models and performed 307 3D print jobs. Of the 96 anatomy models, 82 were used clinically and 14 were used in research. Of the 307 3D printed models, 45 percent were used by Lerner Research Institute, 41 percent were used by clinical institutes and 14 percent were ordered and used by external researchers.
  • The Flow Cytometry Core processed 189 samples for single-cell RNA sequencing.
  • The Genomics Core provides services for 143 users from 105 labs, increasing sequencing data output by approximately 20% compared to 2020.
  • The Imaging Core generated 57,000 raw SEM images and 220,000 images from analysis and provided 26,450 histology tissue slides to 163 Lerner Research Institute labs and eight outside institutions.
  • The Metabolomics Core analyzed more than 4,000 samples, helping to support 85 experiments for 34 different research labs.
  • The Microbial Sequencing and Analytics Resource Facility processed more than 2,000 samples for nucleic acid extraction and microbiome sequencing.
  • The Microbial Culturing and Engineering Facility cultured and engineered microbes for 12 Lerner Research Institute labs and expanded its inventory of microbes to over 300 unique strains.
  • The Proteomics Core analyzed more than 3,200 samples, helping to support 256 experiments for 86 different research labs.
References

For more information about Lerner Research Institute, please visit our website at www.lerner.ccf.org.