Cleveland Clinic’s Wound Healing Center offers wound care management in an outpatient setting. Several facilities feature hyperbaric oxygen chambers. The center uses a multi-disciplinary approach to wound healing and provides complete wound care services to those suffering from diabetic ulcers, pressure ulcers, compromised skin grafts and flaps or wounds that haven’t healed within 30 days.

Cleveland Clinic's Wound Healing Center offers specialized and advanced treatments, resources and options to help patients get on the road to healing.

Treatments & Services

Treatments & Services

Diabetes related wounds

The most common chronic complication of diabetes is diabetic neuropathy, a serious nerve disorder that affects the legs and feet, and causes ulcerations, infections and, in advanced cases, amputation.

Without proper prevention or early detection with proper treatment, diabetic neuropathy can lead to severe complications.

Hyperbaric Oxygen Therapy

Hyperbaric Oxygen Therapy (HBOT) is a medical treatment in which the body is exposed to 100% oxygen while under increased atmospheric pressure. HBOT must be used in addition to standard wound care and is usually recommended when there are no measurable signs of healing after 30 days of standard wound care. 

During treatment, patients can sit back, relax, read, nap or watch a movie; the only physical sensation that may be felt l is slight pressure in the eardrums.

HBOT is used to treat a variety of conditions:

  • Crush injuries and severed limbs.
  • Peripheral arterial insufficiency (muscle pain or cramping in limbs caused by physical activity).
  • Chronic refractory osteomyelitis (persistent bone infection after treatment for osteomyelitis).
  • Osteoradionecrosis (radiation injury to the bone).
  • Injury to the soft tissue caused by radiation.
  • Actinomycosis (inflamed tissue in the mouth or jaw).
  • Diabetic wounds of the lower extremities in people who:
    • Have type I or type II diabetes and a lower extremity wound that is due to diabetes.
    • Have a wound classified as Wagner grade III or higher, which could be classified as gangrene.
    • Have received an unsuccessful course of standard wound therapy.

An evaluation for HBOT will be conducted.

Lower extremity wounds

The Wound Healing Center uses a broad-based approach to treat wounds by a comprehensive team of experts.

The first step is to find the underlying cause of the problem. Lower extremity wounds, such as leg and foot sores, can be caused by one or a combination of problems including poor circulation, diabetes and other medical problems.

Negative pressure therapy

Negative pressure wound therapy (NWPT) is a type of wound care treatment that can be used for wounds on most parts of the body.


The skin is a seamless organ protecting the body from infection. Throughout our lives we have experiences that injure our skin, leaving behind a scar. Scars depend on many factors.

Types of Wounds

Types of Wounds

Persistent non-healing wounds come in many forms. Depending on the type of wound your physician will prescribe a different course of treatment. Some wounds, such as pressure sores, diabetic ulcers, and vascular ulcers may require surgical debridement, which is the removal of weakened or dead tissue. Reconstructive surgery is also a possibility for wound repair.

Diabetic wounds

Diabetic wounds and ulcers often occur on lower extremities and are frequently associated with diabetic neuropathy also known as a decrease in sensation. Diabetic ulcers can be quite severe and sometimes lead to surgical amputation. Diabetic wounds often require management by more than one physician. A surgeon will work in conjunction with your care team if surgery to remove or reconstruct the wound is necessary.

Neoplastic wounds

Skin and soft tissue cancers related to chronic wounds are a frequently under-recognized cause of non-healing. The appearance of a cancerous wound can be fairly unexceptional; as such chronic non-healing wounds that have not responded to traditional wound care regimens benefit from assessment by a wound specialist. The wound care specialist may biopsy, or sample, the soft tissue of the wound for further analysis.

Pressure ulcers

Pressure ulcers develop when external pressure over a bony area cuts off the supply of oxygen and nutrients to soft tissue like skin or muscle. This results in tissue damage. Over time, issues can range from treatable wounds to outright death of the tissue.

The skin is more tolerant of pressure than the underlying fat and muscle. Pressure-related skin changes are the “tip of the iceberg” compared with the extent of the underlying tissue damage. Common locations for pressure ulcers can be the lower back, tail bone, buttocks, heels, back of the head, and the sitting bones.

Radiation related wounds

Radiation-induced tissue injury is a common side-effect of radiation therapy. Tissue changes can occur suddenly or long after therapy is completed and usually appears at the site of treatment but can also appear in the soft tissue nearby.

Radiation related wounds can also develop because of minor trauma to the radiated tissue. Surgical incisions located on or near radiated tissue may have difficulty closing, resulting in non-healing wound.

For some patients, Hyperbaric Oxygen Therapy (HBOT) can be prescribed in addition to conventional medical and surgical care for radiation related tissue injury.

Vascular wounds

Vascular ulcers are wounds which usually occur below the knee as a result of a decreased blood flow and can affect one or both legs. Vascular ulcers are common in patients who have a history of swelling in their legs, varicose veins, or blood clots. Like diabetic ulcers, management usually requires more than one doctor – for example, a surgeon will work  together with a patient's care team if surgery is required.



The Cleveland Clinic Wound Healing Center offers a variety of services throughout the healthcare system. There are several dedicated locations around the region that focus specifically on a multi-disciplinary approach to wound healing. 


Same-day consultations

Same-day consultations are available at these dedicated Wound Healing Center locations:

  • Euclid Hospital
  • Hillcrest Hospital
  • Lutheran Hospital
  • Medina Hospital
  • South Pointe Hospital

Additional wound services

Additional wound services are available at these Cleveland Clinic locations:

  • Akron General
  • Avon Lake Family Health Center
  • Beachwood Family Health and Surgery Center
  • Independence Family Health Center
  • Marymount Hospital
  • Strongsville Family Health and Surgery Center
  • Stephanie Tubbs Jones Health Center
  • Wooster Family Health & Surgery Center