Overview

Overview

Ongoing Pain Management Trials - Is Your Patient A Candidate?

Cleveland Clinic's Department of Pain Management is enrolling patients in a range of ongoing clinical studies.

Back or Leg Pain after Spine Surgery

A multi-centered randomized trial of wireless spinal cord stimulation is underway to demonstrate the efficacy of various stimulation frequencies. This technology is now available without an implantable battery.

The key inclusion criteria are:

  • Chronic back or back and leg pain
  • Previous spine surgery
  • Pain unrelieved by medical treatments

A spinal cord stimulator is placed within the epidural space to deliver electrical signals to diminish pain. No implantable battery will be required. Study-related procedures will be paid by the sponsor. For more information about the STIMWAVE study, please contact Robert Bolash MD, Clinical Site Investigator at bolashr@ccf.org or Natalie Mansour MD, clinical study coordinator at mansoun@ccf.org.

Now Enrolling

Now Enrolling

Study: Tolperisone*

PI: Robert Bolash, MD

Contact: Ogena Saied, MS 216.444.1292

Description/Objective Patient Population Sponsor
Randomized controlled clinical study to determine the efficacy of a nonopioid medication, tolperisone for pain due to acute neck and/or low back muscle spasm. Patients 18 to 65 years of age suffering from acute muscle spasms of the neck or spine. Neurana Pharmaceuticals

Pain Management Trials Now Enrolling Patients

Cleveland Clinic’s Department of Pain Management is enrolling patients in a range of ongoing clinical studies, including those outlined below.

Selected Clinical Trials in the Department of Pain Management

Study: MOTION*
PI: Shrif Costandi, MD
Contact: Erika Taco-Vasquez, MD 216.445.0466

Description/ Objective Patient Population/ Key Inclusion Criteria Sponsor
Randomized controlled clinical study examining functional improvement in lumbar spinal stenosis patients treated with the MILD procedure. Patients 50 to 80 years of age suffering from chronic back and lower limb pain due to Spinal Stenosis. Vertos medical

Study: Target*
PI: Robert Bolash MD
Contact: Erika Taco-Vasquez MD 216.445.0466

Description/ Objective Patient Population/ Key Inclusion Criteria Sponsor
Post Approval study to determine better safety profile of Dorsal Root Ganglion (DRG) stimulation for patients with chronic intractable lower extremity neuropathic pain. Patients 22 to 75 years of age suffering from chronic lower limb pain due to Chronic Regional Pain Syndrome (CRPS). Patient should not have any active implantable device. St. Jude Medical

Study: NEUROS*
PI: Nagy Mekhail, MD, PhD
Contact: Ogena Saied, MS 216.444.1292

Description/ Objective Patient Population/ Key Inclusion Criteria Sponsor
High‐Frequency Nerve Block for Post‐Amputation Pain Patients 21+ years old who have a unilateral amputated lower limb pain and/or phantom pain for more than 12 months. Neuros Medical, Inc

Study: Nevro*
PI: Jijun Xu, MD, PhD
Contact: Sarah Guirguis, MD 216.445.8270

Description/ Objective Patient Population/ Key Inclusion Criteria Sponsor
Post-market study to compare the safety, clinical effectiveness, and cost-effectiveness of the addition of HF10™ therapy to medical management Patients 22+ years old, chronic, intractable, neuropathic lower limb pain due to diabetic neuropathy for at least 12 months that have tried pregabalin or gabapentin in the past Nevro

Study: The Hi-Fi Study*
PI: Robert Bolash, MD
Contact: Ogena Saied, MS 216.444.1292

Description/ Objective Patient Population/ Key Inclusion Criteria Sponsor
Clinical Trial Comparing Ultra-High versus Traditional Pulse Widths using the ALGOVITA® SCS System High Fidelity Stimulation Patients 18-75 years old diagnosed with Failed Back Surgery Syndrome (FBSS) who have chronic back and/or leg pain with no history of implantable devices. Nuvectra

Study: DRG vs. SCS*
PI: Robert Bolash, MD
Contact: Sarah Guirguis, MD 216.445.8270

Description/ Objective Patient Population/ Key Inclusion Criteria Sponsor
Single Center, Randomized Prospective Comparative Effectiveness Study of Dorsal Column Spinal Cord Stimulation to Dorsal Root Ganglion Stimulation in the Treatment of Complex Regional Pain Syndrome Patients with hyperesthesia or allodynia who have failed 4 weeks of conservative management for their CRPS displaying sensory, motor, and/or sudomotor symptoms Cleveland Clinic

*Patients should not have an implantable device