IRB Study Number 23-484
Status Recruiting
Locations U Building - Mellen Center, Cleveland Clinic Main Campus
Institutes Imaging Institute, Neurological Institute
Description
We invite you to take part in a research study because you are a cognitively normal adult between the ages of 60-80 years old. By “cognitively normal”, we mean you have not been diagnosed with a disorder that affects your memory or thinking skills such as dementia or Mild Cognitive Impairment (MCI). The purpose of this study is to look at activation patterns in the brain while completing spatial/object recognition tasks in a magnetic resonance imaging (MRI) machine. “Activation patterns” refers to the way brain cells become active as you try to recall memories. This information will help us identify patterns so researchers can see if they are associated with risk factors for Alzheimer’s disease.
You will be asked to complete a MRI scan. While in the MRI scanner, you will look at a screen and perform memory tasks. You will also complete a series of thinking and memory tasks on paper and an iPad. These tests will be completed in a normal exam room. You will also be asked to have a blood draw as part of the study. Your participation in the research will last a maximum of 4.5 hours. This is a one-time visit.
Inclusion Criteria
Age 60-80
Principal language English
Strongly right handed
Exclusion Criteria
Neurological diagnoses which may affect cognitive function (e.g., dementia, MCI, stroke, Parkinson's disease, multiple sclerosis, or history of serious head trauma (head trauma with loss of consciousness >30 minutes or with permanent neurological sequelae)) or history of alcoholism or drug abuse.
History of chronic major psychiatric disorders (e.g., schizophrenia or major recurrent affective disorder) or the presence of current major depressive episode by DSM-IV criteria (American Psychiatric Association, 1994).
Unstable medical problems (such as unstable heart disease, unstable hypertension, diabetes in poor control, respiratory disease complicated by hypoxia or hypercapnia, infectious illnesses, unstable thyroid dysfunction, treatment for cancer currently or within past two years).
Uncorrected vision or hearing deficits severe enough to interfere with cognitive testing.
Exclusionary medications include: unstable dose of antidepressants, neuroleptics or anxiolytics. CNS stimulants, narcotic analgesics, anti-convulsants, anti-Parkinsonian agents, sedating antihistamines, sedative-hypnotics. Subjects will be nonsmokers.
Claustrophobia, metallic implants, cochlear implants, nerve stimulator, cardiac pacemaker, large tattoos (metallic ink can lead to skin burns), or other contraindicated implants/devices (i.e. vascular stents).
