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Frank DiFilippo, PhD

Frank DiFilippo, PhD
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Department Diagnostic Radiology
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No


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About Frank DiFilippo, PhD

Frank DiFilippo, PhD, is Director of Nuclear Imaging Physics in the Department of Nuclear Medicine in the Cleveland Clinic Imaging Institute. As a medical physicist, his specialty interest is in nuclear medicine instrumentation and image processing for single photon emission computed tomography (SPECT) imaging and positron emission tomography (PET) imaging. A current focus is in multi-modality imaging combining anatomic imaging with x-ray computed tomography (CT) with molecular imaging, using hybrid PET-CT and SPECT-CT scanners.

A native of the Cleveland area, Dr. DiFilippo attended the Case Western Reserve University and graduated with a B.S. degree in physics, where he received the Case Alumni Association Prize for the best academic record for a graduating senior and the Lubrizol Prize in Physics as best graduating physics student. He received his Ph.D. degree in physics from the Massachusetts Institute of Technology under a prestigious National Science Foundation fellowship and a departmental Compton fellowship.

Dr. DiFilippo was appointed to the Cleveland Clinic Department of Nuclear Medicine in 2002. He holds an academic appointment as a Clinical Assistant Professor of Radiology at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and a joint appointment to the Cleveland Clinic Department of Biomedical Engineering. Prior to his appointment to the Cleveland Clinic, Dr. DiFilippo worked as Director of Technology Development of the Cleveland biomedical device company BIOMEC, Inc. Previously he had been a senior scientist in the Nuclear Medicine Division of Picker International (presently Philips Medical Systems) in Highland Heights, Ohio, where he designed and developed components of SPECT and PET imaging systems.

As principal or co-investigator of numerous research projects, Dr. DiFilippo’s research focuses on techniques to optimize PET and SPECT imaging for cardiac, oncologic, and other applications. He has been principal investigator on several research grants from the National Institutes of Health, most recently for development of high-resolution imaging of small animals for basic research. From his prior work in industry, he has been named as primary inventor or co-inventor on seventeen patents. Named in Crain’s Cleveland Business as one of the “Leaders in Technology,” Dr. DiFilippo had been named by Industry Week as one of the “50 R&D Stars to Watch.”

He has written articles and abstracts on his specialty interests and clinical research in leading peer-reviewed publications including the Journal of Nuclear Medicine, Medical Physics, the Journal of Nuclear Cardiology, and Physical Review Letters.

Dr. DiFilippo is a member of the Society of Nuclear Medicine, the American Association of Physicists in Medicine, the American Society of Nuclear Cardiology, and the Institute of Electrical and Electronic Engineers.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Medical Education - Massachusetts Institute of Technology
Experimental Physics
Cambridge, MA USA

Undergraduate - Case Western Reserve University
Cleveland, OH USA

Specialty Interests

nuclear medicine physics, diagnostic imaging physics

Research & Publications

Research & Publications

See publications for Frank DiFilippo, PhD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 2/7/2024, Dr. DiFilippo has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. DiFilippo receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • American College of Radiology

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

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