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Department Rheumatologic and Immunologic Disease
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Locations Specialties & Treatments

Treatment & Services

  • Administration Of Injectable Medications For Osteoporosis
  • Adult Rheumatology
  • Arthritic Knee Conditions
  • Bone Density Testing
  • Clinical Trials
  • Cortisone injections
  • Diagnosis of Osteoporosis
  • Dual Energy X-ray Absorptiometry (DXA)
  • General Rheumatology
  • General Rheumatology including Lupus
  • Hyaluronic acid (HA)
  • Hyaluronic acid injections
  • Immunoglobulin Infusion
  • Immunotherapy
  • Infusion Therapy
  • Infusions Of Biologic Agents On Site
  • Joint Aspiration
  • Joint Injections
  • Joint Preservation Center
  • Medical Management of Early Osteoarthritis
  • Medication Management
  • Musculoskeletal Evaluation
  • Musculoskeletal Medicine
  • Musculoskeletal Treatment For Joint Pain
  • Rheumatology
  • Steroid Injections
  • Therapeutic Injections
  • Ultrasound-guided Procedures
  • Viscosupplementation
  • Viscosupplementation Injections
View all 30 Treatment & Services +

Specialty in Diseases & Conditions

  • EGPA (Eosinophilic granulomatosis with Polyangiitis)
  • AIDS & HIV
  • Ankylosing Spondylitis
  • Antiphospholipid Syndrome
  • Arthritic Knee Problems
  • Arthritis
  • Arthritis Of The Hip
  • Arthritis Of The Knee
  • Arthritis of the Thumb Base
  • Arthritis of the Wrist & Hand
  • Autoimmune Disease
  • Autoinflammatory Syndromes
  • Behcet's Disease
  • Benign Hypermobility Joint Syndrome
  • Buerger's Disease
  • Bursitis
  • Calcification Tendinitis
  • Calcinosis
  • Central Nervous System Vasculitis
  • Chondrocalcinosis (Pseudo Gout)
  • Churg-Strauss Syndrome
  • Connective Tissue Diseases
  • Connective Tissue Disorders
  • Cryoglobulinemia
  • Dermatomyositis
  • Elbow Arthritis
  • Familial Mediterranean Fever
  • Familial Mediterranean Fever (FMF) Syndrome
  • Giant Cell Arteritis
  • Gout
  • Gout Arthritis
  • Granulomatosis with Polyangitis (Wegener’s)
  • Hand and Wrist Arthritis
  • Hand Pain
  • Hand Problems
  • Henoch Schonlein Purpura
  • Hip Arthritis
  • Hip Disorders
  • Hip Pain
  • Immunodeficiency
  • Immunosuppression
  • Inflammatory Arthritis
  • Iritis
  • Joint Pain
  • Knee Arthritis
  • Knee Joint Disorders
  • Knee Pain
  • Lupus
  • Lupus Anticoagulant
  • Lupus Nephritis
  • Metabolic Bone Disease
  • Metabolic Diseases
  • Microscopic Polyangiitis (MPA)
  • Musculoskeletal Disorders
  • Musculoskeletal Impairments
  • Musculoskeletal Pain
  • Myositis
  • Osteoarthritis
  • Osteoarthritis Of The Hips And Knees In The Elderly
  • Painful Joints
  • Palindromic Rheumatism
  • Panuveitis
  • Polumyalgia Rheumatica
  • Polyarteritis Nodosa
  • Polymyositis
  • Pseudogout
  • Psoriatic Arthritis
  • Radiculopathy
  • Raynaud's Phenomenon
  • Reactive Arthritis
  • Relapsing Polychondritis
  • Retroperitoneal Fibrosis
  • Rheumatoid Arthritis
  • Rheumatoid Arthritis and Heart Disease
  • Rheumatoid Arthritis: How to Treat
  • Sacroilitis
  • Sarcoidosis
  • Scleritis
  • Scleroderma
  • Shoulder Arthritis
  • Shoulder Pain
  • Sjogren's Syndrome
  • Spondylitis
  • Spondyloarthopathy
  • Spondyloarthropathies
  • Spondylosis
  • Systemic Autoimmune Diseases
  • Systemic Lupus
  • Systemic Lupus Erythematosus
  • Tendinosis
  • Tendonitis
  • Tenosynovitis
  • Trigger Finger
  • Uveitis
  • Vasculitis
View all 95 Specialties +


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About Brian Mandell, MD, PhD

Brian Mandell, MD, PhD, is board-certified in internal medicine and rheumatology. He is Director of Scholarly Activities of the Internal Medicine Residency Program at Cleveland Clinic, and serves on the Clinic's Board of Governors, the Graduate Medical Education Council, Continuing Health Sciences Education Committee, and Education Governing Group.

Dr. Mandell is also Editor-in-Chief, Cleveland Clinic Journal of Medicine.
Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Hospital of the University of Pennsylvania
Philadelphia, PA USA

Residency - Hospital of the University of Pennsylvania
Internal Medicine
Philadelphia, PA USA

Internship - Hospital of the University of Pennsylvania
Internal Medicine
Philadelphia, PA USA

Medical Education - New York University School of Medicine
New York, NY USA

Medical Education - Washington University School of Medicine
St. Louis, MO USA

Undergraduate - Washington University
St. Louis, MO USA

Additional Training

  • Stanford University Clinical Teaching Faculty Development Program

Professional Highlights

  • Editor, Rheumatology and Allergy Sections, The Merck Manual (home and professional editions)
  • Chair of Annual Scientific Meeting American College Rheumatology
  • Chair of Annual American College of Physicians Annual Meeting


  • Internal Medicine
  • Internal Medicine - Rheumatology

Specialty Interests

Vasculitis, gout, systemic lupus, myositis, multi-system involvement in autoimmune disease

Awards & Honors

  • Cleveland Best Doctors list for many years


  • Association Program Director of Internal Medicine
  • Fellow American College of Rheumatology
  • Fellow American College of Physicians
Research & Publications

Research & Publications

See publications for Brian Mandell, MD, PhD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 4/13/2022, Dr. Mandell has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Mandell receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Horizon CME, Inc.
  • Chemocentryx

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

116 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

45 Patient Comments

Reviewed on Nov 8, 2022

Dr Mandell is very professional and courteous! I didn't feel rushed or as though my concerns weren't valid. He explained things clearly and easily for me while calming any fears or anxieties on my part. Thank you!!

Reviewed on Nov 1, 2022

Excellent physician! That's the reason for coming to Cleveland Clinic.

Reviewed on Oct 19, 2022

Love visiting with Dr Mandell, his staff is very helpful

Reviewed on Oct 18, 2022

Dr. Mandell always makes time to explain and answer any of my questions or concerns.

Reviewed on Oct 17, 2022

So grateful for Dr Mandell and to be as his patient! He diagnosed my polymyositis in 2016 after 5 months of lots of dr appointments, tests, and no answers. After 2 big flares since Nov 2021, he was so caring and helpful regarding where I am today, actions my local Dr and I can take to continue my recovery and how to approach my immunocompromised state with flu season and Covid risk. He is hands down the best doctor I've ever interacted with. So blessed to be his patient.

Reviewed on Sep 13, 2022

Dr Mandel always considers me as part of the team and always answers questions and communicates in a timely manner.

Reviewed on Aug 31, 2022

Dr Mandell took time and listened to me and talked with me and my daughter. I was really impressed!

Reviewed on Aug 31, 2022

Great visit but I traveled 8 hrs to get to appt. Will do it again if dr recommends.

Reviewed on Aug 30, 2022

Dr Mandell is the best Physician at CCF which says a lot!

Reviewed on Jul 13, 2022

The best! I am so happy with Dr. Mandel.

Reviewed on Jul 6, 2022

Dr MAndell is the best.

Reviewed on Jul 6, 2022

Dr Mandel Is a wonderful doctor !!

Reviewed on Jun 15, 2022

Excellent Physician

Reviewed on Jun 8, 2022

Dr. Mandel has always listened to my concerns and helped decide best way to continue my care. He has encouraged me to message with any problems that my ariise.

Reviewed on Jun 7, 2022

Dr Mandela was professional and knowledgeable. However he agreed there was nothing he can do to assist with my situation.

Reviewed on May 25, 2022

Dr. Mandell was truly a breath of hope & confidence in my health saga of over a year. He immediately put my fears aside and explained what was happening with my body. It was a gift to meet him and for him to hear my concerns.

Reviewed on May 23, 2022

Dr. Mandell was very compassionate. He took his time and really reviewed my case before my appt. Although he was not able to give me answers, he was extremely helpful in connecting me to the doctor I should see. I was very impressed with him!

Reviewed on May 17, 2022

I have been a patient of Dr. Mandell s for over 20 years. He is the best!!

Reviewed on May 11, 2022

I wish my primary physician was as great as Dr. Mandala!

Reviewed on May 10, 2022

Dr. Mandell is a wonderful person. Knowledgeable and caring and thorough. Glad he's mt doctor.

Reviewed on May 9, 2022

Dr. Mandela was great! Very respectful, and funnny.

Reviewed on Apr 26, 2022

Dr Mandell returned my call and set up the video appointment very promptly.

Reviewed on Apr 26, 2022

Dr Mandell was exceptional at answering questions and providing all information regarding my condition. He clearly states the plan he had for my treatment and covers all bases.

Reviewed on Apr 26, 2022

Dr Mandell and his staff are exceptional.

Reviewed on Apr 20, 2022

Dr Mandell has always been very responsive to patient needs. As I a from out of state, he has been very accommodating to schedule when I can be there and goes to extra effort to ensure I get top quality care during the time I am available.

Reviewed on Apr 20, 2022

Dr Mandell has been the most reliable and trust worthy doctor I have had during my diagnosis and treatments. I have been blessed and lucky to have found such an incredible and knowledgable medical professional.

Reviewed on Apr 13, 2022

I've rated how well the staff worked together to care for me as good. But, I have no idea how well they work as providers' visits with me are independent, they are one after another.

Reviewed on Mar 29, 2022

Dr Brian Mandell is the best

Reviewed on Mar 29, 2022

*Dr. Mandell is the most caring dr. we have ever had. I would recommend her to everyone.

Reviewed on Mar 9, 2022

Dr. Mandell is wonderful. He has a great doctor patient relationship. He is willing to answer questions and will respond quickly to email inquiries through the portal.

Reviewed on Mar 7, 2022

Dr Brian Mandell is the best, been with him more than 20 yrs. Have referred many fiends.

Reviewed on Mar 1, 2022

It was a very good visit with Dr. Mandell. Listened and took his time with me. Felt very comfortable that he will find out what is going on.

Reviewed on Feb 15, 2022

EXCELLENT, this Doctor LISTENED too me

Reviewed on Feb 8, 2022

In dealing with dr.mandell it has always been wonderful he truly cares and it shows in the way his team response to you. They are always willing to go the extra mile to show you that they care about you and try to help because of dealing with his team Its a pleasure to deal with CCF

Reviewed on Feb 8, 2022

I can't not say enough about Dr. Mandell, when I first came to him I was in pain both physically and mentally. I had no hope of ever being rid of this burden I carried. But through the years he has worked wonders , if he could not fixed the problems he knew Dr's that would. I never invision that my life could take such a turn. But Thanks to his Knowledge , his Ability, and to Care about you as a person has made the difference in my life.

Reviewed on Jan 24, 2022

Excellent doctor and staff

Reviewed on Jan 20, 2022

Dr Mandela is an excellent clinician and has a very caring bedside manner

Reviewed on Jan 19, 2022

This doctor is excellent. One of the best I've ever had.

Reviewed on Jan 18, 2022

Great and caring physician

Reviewed on Jan 12, 2022

Dr. Mandel took all the time necessary to tease out the issues that were troubling me. Never did he seem rushed or impatient with me. He explained his thoughts thoroughly and without jargon.

Reviewed on Jan 5, 2022

Dr Mandell is the best

Reviewed on Dec 30, 2021

Very thorough exam. Necessary tests were done the same day. Very kind personable doctor.

Reviewed on Dec 10, 2021

Excellent visit with a caring and thorough provider

Reviewed on Nov 24, 2021

Dr. Mandela was very knowledgeable, thorough and personable.

Reviewed on Nov 24, 2021

Dr. Mandell was wonderful, actually the best doctor I've seen in a long time.

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