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Department Rheumatologic and Immunologic Disease
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Locations Specialties & Treatments

Treatment & Services

  • Administration of Injectable Medications for Osteoporosis
  • Adult Rheumatology
  • Arthritic Knee Conditions
  • Bone Density Testing
  • Clinical Trials
  • Cortisone Injections
  • Diagnosis of Osteoporosis
  • Dual Energy X-Ray Absorptiometry (DXA)
  • General Rheumatology
  • General Rheumatology Including Lupus
  • Hyaluronic Acid (HA)
  • Hyaluronic Acid Injections
  • Immunoglobulin Infusion
  • Immunotherapy
  • Infusion Therapy
  • Infusions of Biologic Agents on Site
  • Joint Aspiration
  • Joint Injections
  • Joint Preservation Center
  • Medical Management of Early Osteoarthritis
  • Medication Management
  • Musculoskeletal Evaluation
  • Musculoskeletal Medicine
  • Musculoskeletal Treatment for Joint Pain
  • Rheumatology
  • Steroid Injections
  • Therapeutic Injections
  • Ultrasound-guided Procedures
  • Viscosupplementation
  • Viscosupplementation Injections
View all 30 Treatment & Services +

Specialty in Diseases & Conditions

  • AIDS and HIV
  • Ankylosing Spondylitis
  • Antiphospholipid Syndrome
  • Arthritic Knee Problems
  • Arthritis
  • Arthritis of the Hip
  • Arthritis of the Knee
  • Arthritis of the Thumb Base
  • Arthritis of the Wrist and Hand
  • Autoimmune Disease
  • Autoinflammatory Syndromes
  • Behcet's Disease
  • Benign Hypermobility Joint Syndrome
  • Buerger's Disease
  • Bursitis
  • Calcification Tendinitis
  • Calcinosis
  • Central Nervous System Vasculitis
  • Chondrocalcinosis (Pseudo Gout)
  • Churg-Strauss Syndrome
  • Connective Tissue Diseases
  • Connective Tissue Disorders
  • Cryoglobulinemia
  • Dermatomyositis
  • EGPA (Eosinophilic Granulomatosis with Polyangiitis)
  • Elbow Arthritis
  • Familial Mediterranean Fever
  • Familial Mediterranean Fever (FMF) Syndrome
  • Giant Cell Arteritis
  • Gout
  • Gout Arthritis
  • Granulomatosis with Polyangiitis (Wegener’s)
  • Hand and Wrist Arthritis
  • Hand Pain
  • Hand Problems
  • Henoch Schonlein Purpura
  • Hip Arthritis
  • Hip Disorders
  • Hip Pain
  • Immunodeficiency
  • Immunosuppression
  • Inflammatory Arthritis
  • Iritis
  • Joint Pain
  • Knee Arthritis
  • Knee Joint Disorders
  • Knee Pain
  • Lupus
  • Lupus Anticoagulant
  • Lupus Nephritis
  • Metabolic Bone Disease
  • Metabolic Diseases
  • Microscopic Polyangiitis (MPA)
  • Musculoskeletal Disorders
  • Musculoskeletal Impairments
  • Musculoskeletal Pain
  • Myositis
  • Osteoarthritis
  • Osteoarthritis of the Hips and Knees in the Elderly
  • Painful Joints
  • Palindromic Rheumatism
  • Panuveitis
  • Polyarteritis Nodosa
  • Polymyalgia Rheumatica
  • Polymyositis
  • Pseudogout
  • Psoriatic Arthritis
  • Radiculopathy
  • Raynaud's Phenomenon
  • Reactive Arthritis
  • Relapsing Polychondritis
  • Retroperitoneal Fibrosis
  • Rheumatoid Arthritis
  • Rheumatoid Arthritis and Heart Disease
  • Rheumatoid Arthritis: How to Treat
  • Sacroiliitis
  • Sarcoidosis
  • Scleritis
  • Scleroderma
  • Shoulder Arthritis
  • Shoulder Pain
  • Sjogren's Syndrome
  • Spondylitis
  • Spondyloarthopathy
  • Spondyloarthropathies
  • Spondylosis
  • Systemic Autoimmune Diseases
  • Systemic Lupus
  • Systemic Lupus Erythematosus
  • Tendinosis
  • Tendonitis
  • Tenosynovitis
  • Trigger Finger
  • Uveitis
  • Vasculitis
View all 95 Specialties +


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About Brian Mandell, MD, PhD

Brian Mandell, MD, PhD, is board-certified in internal medicine and rheumatology. He is Director of Scholarly Activities of the Internal Medicine Residency Program at Cleveland Clinic, and serves on the Clinic's Board of Governors, the Graduate Medical Education Council, Continuing Health Sciences Education Committee, and Education Governing Group.

Dr. Mandell is also Editor-in-Chief, Cleveland Clinic Journal of Medicine.
Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Hospital of the University of Pennsylvania
Philadelphia, PA USA

Residency - Hospital of the University of Pennsylvania
Internal Medicine
Philadelphia, PA USA

Internship - Hospital of the University of Pennsylvania
Internal Medicine
Philadelphia, PA USA

Medical Education - New York University School of Medicine
New York, NY USA

Medical Education - Washington University School of Medicine
St. Louis, MO USA

Undergraduate - Washington University
St. Louis, MO USA

Additional Training

  • Stanford University Clinical Teaching Faculty Development Program

Professional Highlights

  • Editor, Rheumatology and Allergy Sections, The Merck Manual (home and professional editions)
  • Chair of Annual Scientific Meeting American College Rheumatology
  • Chair of Annual American College of Physicians Annual Meeting


  • Internal Medicine
  • Internal Medicine - Rheumatology

Specialty Interests

Vasculitis, gout, systemic lupus, myositis, multi-system involvement in autoimmune disease

Awards & Honors

  • Cleveland Best Doctors list for many years


  • Association Program Director of Internal Medicine
  • Fellow American College of Rheumatology
  • Fellow American College of Physicians
Research & Publications

Research & Publications

See publications for Brian Mandell, MD, PhD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 3/21/2023, Dr. Mandell has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Mandell receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • Horizon CME, Inc.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

176 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

55 Patient Comments

Reviewed on May 9, 2023

Dr. Brian Mandell was excellent taking time to explain everything and our options for treatment.

Reviewed on Apr 19, 2023

Dr Mandell was one of the best doctors I have ever been treated by. He listened to all of my concerns, was incredibly knowledgeable and thorough, and was very kind. He went out of his way to lessen my anxieties and I appreciate that so much.

Reviewed on Apr 13, 2023

Dr Mandell was one of the most conscientious doctors I have ever seen . He was kind and wanted to get to the source of problem . He never rushed

Reviewed on Apr 13, 2023

I initially did a self referral . The very next day I had an appt scheduled . Dr Mandell has reported all my test to me personally

Reviewed on Mar 30, 2023

Wonderful caring and a great doctor!!

Reviewed on Mar 28, 2023

Dr. Mandell went above and beyond to fit my appointment in. I come from out of state for these treatments and he made it possible to see me, so I would not have to make another trip to Ohio.

Reviewed on Mar 28, 2023

Dr Brian Mandell is the best

Reviewed on Mar 27, 2023

Dr. Mandell is always so pleasant. He is very thorough snd really listens

Reviewed on Mar 27, 2023

Dr Mandel was very thorough in going over lab results and informing me about next steps. He is quick to respond via online portal.

Reviewed on Mar 22, 2023

So pleased with Dr. Mandel. So informative, came home knowing I had seen just the right doctor.

Reviewed on Mar 15, 2023

Dr. Mandell is one of, if not the best, doctor I've had. He is friendly, caring and very knowledgeable. He answers my questions thoroughly and is always responsive to my concerns either in person or online. He's the best!

Reviewed on Mar 15, 2023

He is the most amazing doctor. He always makes me feel like his top priority and that he really cares about my well being. I would definitely recommend him to everyone.

Reviewed on Mar 13, 2023

Have always received highest quality of care from Dr Mandell

Reviewed on Mar 13, 2023

Dr. Mandell expressed sincere concern about my health issues, made me feel heard, was patient in addressing the concerns that both myself and my husband had and went above by addressing additional health concerns without waiting for appt with primary care physician. Due to the concern of this provider, I have made the decision in switching to Cleveland Clinic for all of my needs, even though I was apprehensive about the amount of walking from parking to reach appts, a provider such as he makes it worth it.

Reviewed on Mar 8, 2023

Dr. Mandell is always professional, attentive, sincere...

Reviewed on Mar 2, 2023

Dr. Mandell has a wonderful personality and communicates with care.

Reviewed on Feb 27, 2023

My health improved with the care from parking the car to the staff and doctors visits. I trusted and believed I was was getting the very best care possible. And I did

Reviewed on Feb 27, 2023

I had a very good experience with Dr.Mandel

Reviewed on Feb 23, 2023

The lady who scheduled my appointments for me was the most courteous kindest lady I have met in a very long time for the reasons I was there she took very good interest when the date did not coincide with what I needed she did her best she found me an appointment with a very good doctor

Reviewed on Feb 23, 2023

Dr Mandell answered all my questions with easy to understand language. He was incredibly considerate of my previous Rheumatology team.

Reviewed on Feb 21, 2023

Dr Mandel has been very helpful with my situation.

Reviewed on Feb 20, 2023

Dr. Mandell is aways caring and knowledgeable.

Reviewed on Feb 20, 2023

Dr. Mandel - A1

Reviewed on Feb 14, 2023

Dr. Mandell's assistant scheduled for me.

Reviewed on Feb 14, 2023

5 isn't high enough to rate Dr. Mandell. He is a 10! He practices medicine the good old fashioned way - he takes an excellent history and examines me. He does shared decision making. I really appreciate his skill and knowledge.

Reviewed on Feb 14, 2023

Dr Mandell is caring, professional, and always puts me at ease by answering my question. Best doctor I have!

Reviewed on Feb 8, 2023

Dr. Mandell NEVER makes it seem like he is in a rush, and he listens carefully to all concerns. Thank you!

Reviewed on Feb 2, 2023

Excellent provider

Reviewed on Feb 1, 2023

Dr Mandell always takes the time to address my concerns/questions. We have a good doctor/patient relationship.

Reviewed on Jan 30, 2023

Have NEVER had a doctor spend so much time questioning, recommending and explaining. Amazing!!

Reviewed on Jan 25, 2023

Dr. Mandell was extremely thorough and knowledgeable. He was very kind and spent so much time with me getting a health history and answering questions. I have never had a physician spend so much time and not rush the exam.

Reviewed on Jan 19, 2023

Wonderful and caring Dr.Brian Mandel!!! Excellence all around!!!

Reviewed on Jan 17, 2023

Dr. Mandell is a very caring and knowledgeable doctor.

Reviewed on Jan 16, 2023

Excellent doctor.

Reviewed on Jan 10, 2023

Ive seen over 20 doctors in the past 18 months and Dr. Mandell is the by far the best for too many reasons to list.

Reviewed on Jan 9, 2023

Dr Mandell spent a lot of time with me. He looked at all aspects of my lifestyle and made recommendations.

Reviewed on Dec 14, 2022

Dr Mandell was wonderful. He listened, gave thorough feedback, was genuine and kind, and made me feel heard and confident I received the care I needed.

Reviewed on Nov 16, 2022

I was changed to this doctor after many years seeing another doctor. I continue to find this department outstanding and Dr. Mandell did a great reviewing my health In a short period of time.

Reviewed on Nov 8, 2022

Dr Mandell is very professional and courteous! I didn't feel rushed or as though my concerns weren't valid. He explained things clearly and easily for me while calming any fears or anxieties on my part. Thank you!!

Reviewed on Nov 1, 2022

Excellent physician! That's the reason for coming to Cleveland Clinic.

Reviewed on Oct 19, 2022

Love visiting with Dr Mandell, his staff is very helpful

Reviewed on Oct 18, 2022

Dr. Mandell always makes time to explain and answer any of my questions or concerns.

Reviewed on Oct 17, 2022

So grateful for Dr Mandell and to be as his patient! He diagnosed my polymyositis in 2016 after 5 months of lots of dr appointments, tests, and no answers. After 2 big flares since Nov 2021, he was so caring and helpful regarding where I am today, actions my local Dr and I can take to continue my recovery and how to approach my immunocompromised state with flu season and Covid risk. He is hands down the best doctor I've ever interacted with. So blessed to be his patient.

Reviewed on Sep 13, 2022

Dr Mandel always considers me as part of the team and always answers questions and communicates in a timely manner.

Reviewed on Aug 31, 2022

Dr Mandell took time and listened to me and talked with me and my daughter. I was really impressed!

Reviewed on Aug 31, 2022

Great visit but I traveled 8 hrs to get to appt. Will do it again if dr recommends.

Reviewed on Aug 30, 2022

Dr Mandell is the best Physician at CCF which says a lot!

Reviewed on Jul 13, 2022

The best! I am so happy with Dr. Mandel.

Reviewed on Jul 6, 2022

Dr MAndell is the best.

Reviewed on Jul 6, 2022

Dr Mandel Is a wonderful doctor !!

Reviewed on Jun 15, 2022

Excellent Physician

Reviewed on Jun 8, 2022

Dr. Mandel has always listened to my concerns and helped decide best way to continue my care. He has encouraged me to message with any problems that my ariise.

Reviewed on Jun 7, 2022

Dr Mandela was professional and knowledgeable. However he agreed there was nothing he can do to assist with my situation.

Reviewed on May 25, 2022

Dr. Mandell was truly a breath of hope & confidence in my health saga of over a year. He immediately put my fears aside and explained what was happening with my body. It was a gift to meet him and for him to hear my concerns.

Reviewed on May 23, 2022

Dr. Mandell was very compassionate. He took his time and really reviewed my case before my appt. Although he was not able to give me answers, he was extremely helpful in connecting me to the doctor I should see. I was very impressed with him!

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