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Department Allergy and Clinical Immunology
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Treatment & Services

  • Allergy Immunotherapy
  • Allergy Skin Tests
  • Allergy Tests
  • Blood Tests
  • Clinical Trials
  • Diagnosing Asthma
  • Diagnostic Skin Testing for Food, Inhalant, and Drug Allergy
  • Drug Allergy Desensitization Therapy
  • Drug Challenge
  • Drug Desensitization
  • Exhaled Breath Analysis
  • Food Challenge Test
  • Health Screening and Testing
  • Immunodeficiency Evaluation
  • Immunotherapy
  • Intravenous Immunoglobulin Therapy
  • Peak Flow Meter
  • Pulmonary Function Testing
  • Subcutaneous Immunoglobulin Therapy
  • Treating Asthma with Bronchodilators
View all 20 Treatment & Services +

Specialty in Diseases & Conditions

  • Acute Sinusitis
  • Airborne Allergens
  • Allergic Conjunctivitis
  • Allergic Disorders
  • Allergic Rhinitis
  • Allergies
  • Anaphylaxis
  • Angioedema
  • Asthma
  • Bee Stings
  • Dermatitis
  • Drug Allergy
  • Eczema
  • Egg Allergy
  • Environmental Allergies
  • Eosinophilia
  • Fish Allergy
  • Food Allergies
  • Hay Fever
  • Hereditary Angioedema
  • Hives (Urticaria)
  • Idiopathic Angioedema
  • Immunodeficiency
  • Insect Sting Allergies
  • Latex Allergy
  • Mastocytosis
  • Medication Allergies
  • Milk Allergy
  • Nasal Polyps
  • Nut Allergy
  • Ocular Allergies
  • Seasonal Allergies
  • Shellfish Allergy
  • Soy Allergy
  • Urticaria
  • Wheat Allergy
View all 36 Specialties +


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About Lily Pien, MD, MHPE

Lily C. Pien, MD, MHPE is Staff Attending in the Department of Allergy and Immunology in the Respiratory Institute. She is Associate Director of Faculty Development in the Center for Educational Resources.  Dr. Pien is a Professor of Medicine in the Cleveland Clinic Lerner College of Medicine.

She is certified by the American Board of Internal Medicine and the American Board of Allergy and Immunology.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Graduate School - University of Illinois at Chicago College of Medicine
Chicago, IL

Fellowship - Northwestern Memorial Hospital
Chicago, IL

Residency - Northwestern Memorial Hospital
Internal Medicine
Chicago, IL

Internship - Northwestern Memorial Hospital
Internal Medicine
Chicago, IL

Medical Education - Northwestern University Feinberg School of Medicine
Chicago, IL

Undergraduate - Northwestern University
Evanston, IL

Additional Training

  • Cleveland Clinic Medical Education Fellowship
  • Case Western Reserve University Scholars Collaboration in Teaching and Learning


  • Internal Medicine
  • Allergy and Immunology

Specialty Interests

Allergic Rhinitis, Asthma, medical education

Awards & Honors

  • Case Western Reserve University Scholarships in Teaching Award
  • Resident Educator and Life Camp Leader Resident Development Award 2008
  • Teacher of the Year, Cleveland Clinic Allergy and Immunology Department
  • America's Top Doctors
  • Cleveland Magazine Best Doctors
Research & Publications

Research & Publications

See publications for Lily Pien, MD, MHPE.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 4/1/2024, Dr. Pien has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

63 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.5 out of 5
Explains 4.5
Courtesy, Respect & Concern 4.6
Patient Rating of Doctor 4.6

15 Patient Comments

Reviewed on May 3, 2024

Dr Pien was easy to talk to and I felt like she cared about me and suggested I call my local ENT to be evaluated further and she also ordered bloodwork.

Reviewed on May 2, 2024

This lady has been my doctor for about 30 years. I've never had an issue and I don't plan on changing anything.

Reviewed on May 1, 2024

Dr Pien is the best Doctor

Reviewed on May 1, 2024

Five stars for Dr Pien

Reviewed on Apr 3, 2024

She was very respectful of my condition and of the questions I asked

Reviewed on Mar 1, 2024

Felt very dismissive about my health and wellbeing and as if she didn't really care much. Will not be recommending this doctor to anyone and will not be returning to her

Reviewed on Feb 1, 2024

Very easy to contact Dr. Pien and schedule an appointment.

Reviewed on Feb 1, 2024

Excellent visit -- Dr. Pien is very knowledgeable, professional and caring.

Reviewed on Jan 12, 2024

Dr. Puente is fantastic. She listens, she's knowledgeable, gives options and follows up. Can't recommend her highly enough!

Reviewed on Dec 14, 2023

I was very pleased with Dr Pien in all aspects of my consult with her.

Reviewed on Nov 9, 2023

I had an amazing experience at the Cleveland Clinic. Unfortunately, Dr. Pien was not able to help me with my Long Haul Covid symptoms of shortness of breath.

Reviewed on Oct 19, 2023

Dr Pien is very gracious. She listened, answered questions and offered clear explanations.

Reviewed on Sep 21, 2023

Whereas Dr. Pien acknowledged having no expertise with the underlying health issue that precipitated my seeming allergic responses, again, it's impossible for me to answer any questions re "usefulness" of this appt. Otherwise, Dr. Pien impressed me with her professionalism, forthrightness, intelligence, and caring demeanor.

Reviewed on Jul 21, 2023

Dr. Pien is a caring and kind physician who is also a skilled communicator and teacher. I enjoy our dialogue and feel comfortable asking questions. I also appreciate that if she needs to do additional research to respond to an inquiry she takes the time to answer questions fully and completely.

Reviewed on Jun 8, 2023

Dr Pien is AMAZING. She is incredibly knowledgeable. I never feel rushed, she answers all my questions. She is caring. Rare find in the medical field. BEST DR

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