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Department Cardiovascular Medicine
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English, Italian
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Treatment & Services

  • Cardiac Electrophysiology and Pacing Section
View all 1 Treatment & Services +


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About Pasquale Santangeli, MD, PhD

Pasquale Santangeli, MD, PhD, is associate section head and director of the ventricular tachycardia (VT) program in the Cardiac Electrophysiology and Pacing Section of the Tomsich Family Department of Cardiovascular Medicine, Miller Family Heart, Vascular & Thoracic Institute. He sees patients at Main Campus.

Specialty Interests: Catheter ablation, ventricular tachycardia (VT), ventricular fibrillation, premature ventricular complexes, atrial fibrillation (AF), atrial flutter, supraventricular tachycardia, arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, left atrial appendage closure, Wolff-Parkinson-White syndrome (WPW), biventricular pacemaker (CRT), implantable cardioverter defibrillator (ICD)

Experience: The Cardiac Electrophysiology and Pacing Section offers a range of highly specialized approaches to diagnose and treat patients with heart rhythm problems (arrhythmia). The Section’s specialists annually perform nearly 6,000 procedures in the Electrophysiology Lab, including pacemaker and defibrillator implantations, ablations of various types of arrhythmias and cardioversions.

Success Rates: Cleveland Clinic is nationally and internationally renowned for the world’s best cardiovascular care, drawing patients from across the country and around the world. To learn about patient outcomes for specific conditions and procedures at Cleveland Clinic, go to http://my.clevelandclinic.org/heart/about-heart-vascular-institute/treatment-outcomes.aspx

Education: Dr. Santangeli holds a doctorate in medicine from Catholic University of the Sacred Heart, Rome, Italy, and a doctorate in medical and epidemiological sciences from the University of Foggia, Foggia, Italy. After completing his studies, he remained at Catholic University for his cardiovascular diseases fellowship.

Dr. Santangeli began his subspecialty training as a research fellow in cardiac electrophysiology at Texas Cardiac Arrhythmia Institute, St. David’s Medical Center, Austin, Texas. He continued his training with two fellowships in clinical cardiac electrophysiology, first at Stanford University School of Medicine, Stanford, Calif., and finishing at Hospital of the University of Pennsylvania, Philadelphia.

Prior to joining the Cleveland Clinic medical staff in 2022, Dr. Santangeli was a staff electrophysiologist, associate professor of medicine, director of the Catheter Ablation Research Program, co-director of the Penn Ventricular Tachycardia Center of Excellence and director of EP Innovation and Clinical Research at Hospital of the University of Pennsylvania.

Research, Publications and Speaking: Dr. Santangeli has served as principal investigator for clinical studies to determine the efficacy and improve safety of catheter ablation of atrial fibrillation (AF) and ventricular tachycardia (VT).
Dr. Santangeli has coauthored more than 500 research papers, abstracts, editorials, review papers and case reports published in leading medical journals. He has editorial responsibilities with a number of prestigious journals, including Circulation: Arrhythmia and Electrophysiology, Heart Rhythm Journal and JACC: Clinical Electrophysiology and also has coauthored more than a dozen chapters for electrophysiology textbooks. He is a frequent invited lecturer and presenter at medical meetings in the United States and internationally, speaking on all aspects of catheter ablation of cardiac rhythm disorders.

An innovator in his field, Dr. Santangeli has developed several new techniques and technologies for treating AF and VT, typically in patients with complicated arrhythmias or challenging anatomy.

About Dr. Santangeli: “It is a privilege to serve patients with cardiac arrhythmia disorders, and my greatest reward is to solve their arrhythmia problems and restore quality of life. I am committed to delivering excellent clinical outcomes through compassionate, evidence-based and innovative care.”

Leisure Activities: In his leisure time, Dr. Santangeli enjoys travel, nature, hiking and spending time with family.
Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Medical Education - University of Foggia
Foggia, Puglia, Italy

Fellowship - Hospital of the University of Pennsylvania
Cardiac Electrophysiology
Philadelphia, PA USA

Fellowship - Stanford School of Medicine
Cardiac Electrophysiology
Stanford, CA USA

Fellowship - Texas Cardiac Arrhythmia Institute
Austin, TX USA

Medical Education - Catholic University of Sacred Heart
Rome, Italy


  • Internal Medicine - Cardiovascular Disease

Awards & Honors

  • 2022 :  Abstract finalist, Mark E. Josephson Abstract Competition & VT Innovation Award, VT            Symposium 2022, New York
    2020 :  First Mid-Atlantic Medical Awards recipient, Philadelphia
    2018 : Knight of the Order of Merit of the Italian Republic
    2014, 2015 : Best Reviewer, Annals of Internal Medicine
    2014 : Best Fellow-in-Training Abstract Award, American College of Cardiology Scientific Session,    Washington, DC
    2013 : Early-Career Best Poster Award, American Heart Association Scientific Session, Dallas
    2012 : Best Paper Award, European Cardiac Arrhythmia Society Congress, Munich
               Best Paper Award, World Society of Arrhythmias Congress, Athens
    2011 : Best Oral Abstract Presentation Award, Best Poster Abstract Presentation Award, CardioRhythm    2011, Hong Kong
Research & Publications

Research & Publications

See publications for Pasquale Santangeli, MD, PhD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 9/25/2023, Dr. Santangeli has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Santangeli receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • Medical Device Business Services, Inc., formerly Depuy, Inc.
  • Boston Scientific Corporation
  • Abbott Laboratories

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

248 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 4.6
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

53 Patient Comments

Reviewed on Jan 3, 2024

I was so impressed with Dr. Santangeli. Very, very bright, great communicator, very thorough, carefully explained every aspect of the problem and possible treatments.Very easy to talk to

Reviewed on Dec 20, 2023

The provider is very kind, knowledgeable and helpful. He added the ZIO Monitor and personally placed the order to make sure that I would get it ASAP.

Reviewed on Dec 18, 2023

Dr. Santangeli was genuinely happy with my results. His supportive and positive demeanor validated my choice to come to Cleveland Clinic and the blessing that I was assigned Dr. Santangeli.

Reviewed on Dec 18, 2023

Everyone was way better than expected. Very impressed...especially with my doctor!

Reviewed on Dec 6, 2023

Staff is great, Amanda RN was awesome. Having nurses do vitals and assessing pts before MD is what sets apart from other Medical Centers. The value of a nurse assessing patients is well worth It. That is why outcomes are better when compared to other medical Centers. Access to system is like all health care these days scheduling 90 -120 days out seems outlandish.

Reviewed on Dec 4, 2023

Nurses and the doctor worked great with me getting it set-up quickly.

Reviewed on Dec 4, 2023

I'm so pleased with the care of my doctor and the attention that he provide to me about my conditions.

Reviewed on Dec 4, 2023

All staff and all my doctors are professional and care about my health.

Reviewed on Dec 4, 2023

So well organized for such a large and busy complex! All of the staff from registration staff, EKG tech, nurses and Physicians were so friendly and efficient!

Reviewed on Dec 4, 2023

Great Physician, friendly and easy to understand. Obviously an excellent Physician!

Reviewed on Nov 27, 2023

I was very impressed with the doctor and his manner to both my wife and myself.

Reviewed on Nov 27, 2023

I feel Dr. Santangeli could not have chosen a better endeavor for his personality. It is more than just a job to him, his natural compassion for human life is obvious. I feel so very blessed to have him as my heart doctor.

Reviewed on Nov 27, 2023

Dr. Santangeli cared about what mattered to me, explained approach to my condition with evidence and statistics.

Reviewed on Nov 27, 2023

I have complete confidence in my physician.

Reviewed on Nov 22, 2023

Dr. Santangelli has great bedside manner, he listened to all of my concerns and helped create an individual plan to fit my needs. I am very grateful to have been under his care.

Reviewed on Nov 20, 2023

Dr Sangangeli was everything I hoped for and more. He explained everything to me, my husband, and son and listened to all our questions and concerns!!!

Reviewed on Oct 30, 2023

Dr. Santangeli is not only brilliant, but very personable, and makes sure to give great explanations.

Reviewed on Oct 30, 2023

The doctor & all the staff at CC are kind, compassionate & professional!!

Reviewed on Oct 25, 2023

Dr Santangeli was exceptional. Very thankful and grateful to have been referred to him.

Reviewed on Oct 25, 2023

Dr Santangeli is an amazing physician!

Reviewed on Oct 16, 2023

Outstanding Dr. Traveled from Boston to Cleveland for this appt - glad to have done so.

Reviewed on Sep 27, 2023

Dr Santangeli was very caring and professional

Reviewed on Sep 18, 2023

Very good. The nurse was very competent during the intake. Dr Santangeli was very calming and thorough and reassuring.

Reviewed on Sep 18, 2023

Wonderful Dr with perfect patient rapport! Very courteous and knowledgeable.

Reviewed on Sep 18, 2023

Very good Doctor

Reviewed on Sep 13, 2023

Dr. Santangeli is outstanding

Reviewed on Aug 30, 2023

Dr. Santangeli was excellent in all phases of care.He is professional, confident, and kind.

Reviewed on Aug 30, 2023

Dr. Santangeli and his fellow were exhumed professionalism! He went out of his way to communicate to myself and wife.

Reviewed on Aug 30, 2023

I did have one concern. I was given light sedation. I overheard the anesthesiologist tell the CRNa that it was a general anesthetic.As a physician raised by an anesthesiologist I do question that. It may be an ethical issue??

Reviewed on Aug 28, 2023

Dr. Santangeli is just wonderful! He took his time and explained everything to me. He answered all my questions and concerns. This was a three month follow up visit for my surgery. It was so nice to have a doctor who really cares about how I am doing, how I feel and is supportive and understanding. I couldn't ask for a better doctor than Dr. Santangeli !

Reviewed on Aug 28, 2023

Dr. Is a wonderful person and fantastic Dr.I have recommended him to 2 of my family members.

Reviewed on Aug 21, 2023

Doctor was very friendly, very professional, spent time answering questions

Reviewed on Jul 19, 2023

Very impressed with everything and every provider I met; especially Dr Santatali.

Reviewed on Jul 11, 2023

During my stay, I was mostly under the direct care of my Doctor's PA. She was fantastic and very thorough.

Reviewed on Jul 11, 2023

*Dr. Santangeli was patient thorough and understanding.

Reviewed on Jul 5, 2023

*Dr. Shay Naklla & team in OR the best.

Reviewed on May 15, 2023

Dr. Sangateli was very nice. Upfront and caring!

Reviewed on May 10, 2023

Dr Santangeli is great!

Reviewed on May 1, 2023

Doctor was very well informed and was very thoughtful in answering my questions.

Reviewed on May 1, 2023

Great doctor and staff

Reviewed on Apr 24, 2023

Excellent physician!

Reviewed on Apr 24, 2023

Dr. Santangeli was very knowledgeable and informative about my concerns. He provided positive feedback and put me more at ease. We drove from Philadelphia and we will absolutely do it again. Everything was organized and everyone was friendly and welcoming. It made coming to a place where you are probably scared to begin with a lot easier.

Reviewed on Apr 24, 2023

Dr.S was amazing. He made sure I understood everything. He gave me options and explained the pros and cons of each. He let me choose the option that I felt was best for me. He answered all my questions and made sure I understood his answers. He was positive, kind and caring. He took his time with me. I did not feel rushed. I had a great experience with this doctor!

Reviewed on Apr 17, 2023

I travel to Cleveland for my visits. I think so much of Dr. Santangeli that I would travel to wherever he is located.

Reviewed on Apr 17, 2023

Love my doctor

Reviewed on Apr 12, 2023

Doctor Santangeli was very friendly, easy to talk to about my problems, showed a genuine concern and elaborated about ongoing therapy.

Reviewed on Apr 10, 2023

Glad this doctor was a better choice based on my care

Reviewed on Mar 15, 2023

Dr. Santangeli was excellent in explaining my upcoming procedure. Didn't rush , took time ,

Reviewed on Mar 6, 2023

Both the NP and Doctor were outstanding in their knowledge and care. They both spent enough time asking questions and answering any I had.

Reviewed on Mar 1, 2023

The Dr. And the Fellow were excellent kind and very professional. I felt very safe in their hands.

Reviewed on Mar 1, 2023

I would highly recommend my Dr. And Cleveland Clinic.

Reviewed on Feb 27, 2023

We were very pleased with the care we received from Dr. Santangeli & Cleveland Clinic.

Reviewed on Feb 6, 2023

Dr. Santangeli and staff were wonderful very professional, friendly, and knowledgeable.

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