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Department Cardiovascular Medicine
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English, Italian
Surgeon No
Locations Specialties & Treatments

Treatment & Services

  • Cardiac Electrophysiology and Pacing Section
View all 1 Treatment & Services +


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About Pasquale Santangeli, MD, PhD

Pasquale Santangeli, MD, PhD, is associate section head and director of the ventricular tachycardia (VT) program in the Cardiac Electrophysiology and Pacing Section of the Tomsich Family Department of Cardiovascular Medicine, Miller Family Heart, Vascular & Thoracic Institute. He sees patients at Main Campus.

Specialty Interests: Catheter ablation, ventricular tachycardia (VT), ventricular fibrillation, premature ventricular complexes, atrial fibrillation (AF), atrial flutter, supraventricular tachycardia, arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, left atrial appendage closure, Wolff-Parkinson-White syndrome (WPW), biventricular pacemaker (CRT), implantable cardioverter defibrillator (ICD)

Experience: The Cardiac Electrophysiology and Pacing Section offers a range of highly specialized approaches to diagnose and treat patients with heart rhythm problems (arrhythmia). The Section’s specialists annually perform nearly 6,000 procedures in the Electrophysiology Lab, including pacemaker and defibrillator implantations, ablations of various types of arrhythmias and cardioversions.

Success Rates: Cleveland Clinic has been rated the top heart center in the United States by U.S. News & World Report for more than 20 consecutive years, drawing patients from across the country and around the world. To learn about patient outcomes for specific conditions and procedures at Cleveland Clinic, go to

Education: Dr. Santangeli holds a doctorate in medicine from Catholic University of the Sacred Heart, Rome, Italy, and a doctorate in medical and epidemiological sciences from the University of Foggia, Foggia, Italy. After completing his studies, he remained at Catholic University for his cardiovascular diseases fellowship.

Dr. Santangeli began his subspecialty training as a research fellow in cardiac electrophysiology at Texas Cardiac Arrhythmia Institute, St. David’s Medical Center, Austin, Texas. He continued his training with two fellowships in clinical cardiac electrophysiology, first at Stanford University School of Medicine, Stanford, Calif., and finishing at Hospital of the University of Pennsylvania, Philadelphia.

Prior to joining the Cleveland Clinic medical staff in 2022, Dr. Santangeli was a staff electrophysiologist, associate professor of medicine, director of the Catheter Ablation Research Program, co-director of the Penn Ventricular Tachycardia Center of Excellence and director of EP Innovation and Clinical Research at Hospital of the University of Pennsylvania.

Research, Publications and Speaking: Dr. Santangeli has served as principal investigator for clinical studies to determine the efficacy and improve safety of catheter ablation of atrial fibrillation (AF) and ventricular tachycardia (VT).
Dr. Santangeli has coauthored more than 500 research papers, abstracts, editorials, review papers and case reports published in leading medical journals. He has editorial responsibilities with a number of prestigious journals, including Circulation: Arrhythmia and Electrophysiology, Heart Rhythm Journal and JACC: Clinical Electrophysiology and also has coauthored more than a dozen chapters for electrophysiology textbooks. He is a frequent invited lecturer and presenter at medical meetings in the United States and internationally, speaking on all aspects of catheter ablation of cardiac rhythm disorders.

An innovator in his field, Dr. Santangeli has developed several new techniques and technologies for treating AF and VT, typically in patients with complicated arrhythmias or challenging anatomy.

About Dr. Santangeli: “It is a privilege to serve patients with cardiac arrhythmia disorders, and my greatest reward is to solve their arrhythmia problems and restore quality of life. I am committed to delivering excellent clinical outcomes through compassionate, evidence-based and innovative care.”

Leisure Activities: In his leisure time, Dr. Santangeli enjoys travel, nature, hiking and spending time with family.
Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Medical Education - University of Foggia
Foggia, Puglia, Italy

Fellowship - Hospital of the University of Pennsylvania
Cardiac Electrophysiology
Philadelphia, PA USA

Fellowship - Stanford School of Medicine
Cardiac Electrophysiology
Stanford, CA USA

Fellowship - Texas Cardiac Arrhythmia Institute
Austin, TX USA

Medical Education - Catholic University of Sacred Heart
Rome, Italy

Awards & Honors

  • 2022 :  Abstract finalist, Mark E. Josephson Abstract Competition & VT Innovation Award, VT            Symposium 2022, New York
    2020 :  First Mid-Atlantic Medical Awards recipient, Philadelphia
    2018 : Knight of the Order of Merit of the Italian Republic
    2014, 2015 : Best Reviewer, Annals of Internal Medicine
    2014 : Best Fellow-in-Training Abstract Award, American College of Cardiology Scientific Session,    Washington, DC
    2013 : Early-Career Best Poster Award, American Heart Association Scientific Session, Dallas
    2012 : Best Paper Award, European Cardiac Arrhythmia Society Congress, Munich
               Best Paper Award, World Society of Arrhythmias Congress, Athens
    2011 : Best Oral Abstract Presentation Award, Best Poster Abstract Presentation Award, CardioRhythm    2011, Hong Kong
Research & Publications

Research & Publications

See publications for Pasquale Santangeli, MD, PhD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 9/28/2022, Dr. Santangeli has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Santangeli receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • Abbott Laboratories
  • Biosense Webster, Inc.
  • Baylis Medical Company, Inc.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

157 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

29 Patient Comments

Reviewed on May 15, 2023

Dr. Sangateli was very nice. Upfront and caring!

Reviewed on May 10, 2023

Dr Santangeli is great!

Reviewed on May 1, 2023

Doctor was very well informed and was very thoughtful in answering my questions.

Reviewed on May 1, 2023

Great doctor and staff

Reviewed on Apr 24, 2023

Excellent physician!

Reviewed on Apr 24, 2023

Dr. Santangeli was very knowledgeable and informative about my concerns. He provided positive feedback and put me more at ease. We drove from Philadelphia and we will absolutely do it again. Everything was organized and everyone was friendly and welcoming. It made coming to a place where you are probably scared to begin with a lot easier.

Reviewed on Apr 24, 2023

Dr.S was amazing. He made sure I understood everything. He gave me options and explained the pros and cons of each. He let me choose the option that I felt was best for me. He answered all my questions and made sure I understood his answers. He was positive, kind and caring. He took his time with me. I did not feel rushed. I had a great experience with this doctor!

Reviewed on Apr 17, 2023

I travel to Cleveland for my visits. I think so much of Dr. Santangeli that I would travel to wherever he is located.

Reviewed on Apr 17, 2023

Love my doctor

Reviewed on Apr 12, 2023

Doctor Santangeli was very friendly, easy to talk to about my problems, showed a genuine concern and elaborated about ongoing therapy.

Reviewed on Apr 10, 2023

Glad this doctor was a better choice based on my care

Reviewed on Mar 15, 2023

Dr. Santangeli was excellent in explaining my upcoming procedure. Didn't rush , took time ,

Reviewed on Mar 6, 2023

Both the NP and Doctor were outstanding in their knowledge and care. They both spent enough time asking questions and answering any I had.

Reviewed on Mar 1, 2023

The Dr. And the Fellow were excellent kind and very professional. I felt very safe in their hands.

Reviewed on Mar 1, 2023

I would highly recommend my Dr. And Cleveland Clinic.

Reviewed on Feb 27, 2023

We were very pleased with the care we received from Dr. Santangeli & Cleveland Clinic.

Reviewed on Feb 6, 2023

Dr. Santangeli and staff were wonderful very professional, friendly, and knowledgeable.

Reviewed on Jan 30, 2023

Dr. Santangeli is a superstar!

Reviewed on Jan 16, 2023

Dr. Santangeli is absolutely the best. Professional, caring and takes the time necessary to explain med issues in language that I can understand and process.

Reviewed on Jan 9, 2023

My experience so far with your hospital has been great! A much needed breath of fresh air after my recent doctors visits In the Toledo area. I feel very comfortable with my new doctor and nurses.

Reviewed on Dec 21, 2022

The Doctor was great and very calming and informative. The nurse was not very friendly, or understanding. She is probably over worked.

Reviewed on Dec 21, 2022

My answers refer to Dr. Pasquale SantangeliFantastic Doctor.

Reviewed on Dec 21, 2022

Dr was amazing, listened and explained course of treatment including me in decisions!

Reviewed on Dec 21, 2022

Doctor Santangeli was excellent. He thoroughly explained all testing results and findings and answered my questions with evidenced based responses. He was thorough, thoughtful, and an a gifted communicator!

Reviewed on Dec 19, 2022

Doctor Santangeli is an amazing electrophysiologist and compassionate person who took the time to explain the details of my ablation; he followed up regularly himself during my stay in the hospital. During my consultation visits prior to my procedure he knew all the details of my medical records and wasted no time getting right the next steps. I was extremely impressed!

Reviewed on Dec 5, 2022

The doctor was great. He answered most of our questions before we even asked them. Very personable.

Reviewed on Nov 7, 2022

First rate doctor & team.

Reviewed on Oct 31, 2022

Explained surgical process in detail that I had never knew from previous surgery with another provider. Gave us options and choices. Would have liked more explanation of why arythmia was occurring and where and how in the heart it affects and occurs. A bit of diagramming and physiology

Reviewed on Oct 10, 2022

If you have a heart problem Dr. Santangeli is the expert to see!

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