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Department Cardiovascular Medicine
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English, Italian
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Treatment & Services

  • Cardiac Electrophysiology and Pacing Section
View all 1 Treatment & Services +


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About Pasquale Santangeli, MD, PhD

Pasquale Santangeli, MD, PhD, is associate section head and director of the ventricular tachycardia (VT) program in the Cardiac Electrophysiology and Pacing Section of the Tomsich Family Department of Cardiovascular Medicine, Miller Family Heart, Vascular & Thoracic Institute. He sees patients at Main Campus.

Specialty Interests: Catheter ablation, ventricular tachycardia (VT), ventricular fibrillation, premature ventricular complexes, atrial fibrillation (AF), atrial flutter, supraventricular tachycardia, arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, left atrial appendage closure, Wolff-Parkinson-White syndrome (WPW), biventricular pacemaker (CRT), implantable cardioverter defibrillator (ICD)

Experience: The Cardiac Electrophysiology and Pacing Section offers a range of highly specialized approaches to diagnose and treat patients with heart rhythm problems (arrhythmia). The Section’s specialists annually perform nearly 6,000 procedures in the Electrophysiology Lab, including pacemaker and defibrillator implantations, ablations of various types of arrhythmias and cardioversions.

Success Rates: Cleveland Clinic is nationally and internationally renowned for the world’s best cardiovascular care, drawing patients from across the country and around the world. To learn about patient outcomes for specific conditions and procedures at Cleveland Clinic, go to http://my.clevelandclinic.org/heart/about-heart-vascular-institute/treatment-outcomes.aspx

Education: Dr. Santangeli holds a doctorate in medicine from Catholic University of the Sacred Heart, Rome, Italy, and a doctorate in medical and epidemiological sciences from the University of Foggia, Foggia, Italy. After completing his studies, he remained at Catholic University for his cardiovascular diseases fellowship.

Dr. Santangeli began his subspecialty training as a research fellow in cardiac electrophysiology at Texas Cardiac Arrhythmia Institute, St. David’s Medical Center, Austin, Texas. He continued his training with two fellowships in clinical cardiac electrophysiology, first at Stanford University School of Medicine, Stanford, Calif., and finishing at Hospital of the University of Pennsylvania, Philadelphia.

Prior to joining the Cleveland Clinic medical staff in 2022, Dr. Santangeli was a staff electrophysiologist, associate professor of medicine, director of the Catheter Ablation Research Program, co-director of the Penn Ventricular Tachycardia Center of Excellence and director of EP Innovation and Clinical Research at Hospital of the University of Pennsylvania.

Research, Publications and Speaking: Dr. Santangeli has served as principal investigator for clinical studies to determine the efficacy and improve safety of catheter ablation of atrial fibrillation (AF) and ventricular tachycardia (VT).
Dr. Santangeli has coauthored more than 500 research papers, abstracts, editorials, review papers and case reports published in leading medical journals. He has editorial responsibilities with a number of prestigious journals, including Circulation: Arrhythmia and Electrophysiology, Heart Rhythm Journal and JACC: Clinical Electrophysiology and also has coauthored more than a dozen chapters for electrophysiology textbooks. He is a frequent invited lecturer and presenter at medical meetings in the United States and internationally, speaking on all aspects of catheter ablation of cardiac rhythm disorders.

An innovator in his field, Dr. Santangeli has developed several new techniques and technologies for treating AF and VT, typically in patients with complicated arrhythmias or challenging anatomy.

About Dr. Santangeli: “It is a privilege to serve patients with cardiac arrhythmia disorders, and my greatest reward is to solve their arrhythmia problems and restore quality of life. I am committed to delivering excellent clinical outcomes through compassionate, evidence-based and innovative care.”

Leisure Activities: In his leisure time, Dr. Santangeli enjoys travel, nature, hiking and spending time with family.
Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Medical Education - University of Foggia
Foggia, Puglia, Italy

Fellowship - Hospital of the University of Pennsylvania
Cardiac Electrophysiology
Philadelphia, PA United States

Fellowship - Stanford School of Medicine
Cardiac Electrophysiology
Stanford, CA

Fellowship - Texas Cardiac Arrhythmia Institute
Austin, TX United States

Medical Education - Catholic University of Sacred Heart
Rome, Italy


  • Internal Medicine - Cardiovascular Disease

Awards & Honors

  • 2022 :  Abstract finalist, Mark E. Josephson Abstract Competition & VT Innovation Award, VT            Symposium 2022, New York
    2020 :  First Mid-Atlantic Medical Awards recipient, Philadelphia
    2018 : Knight of the Order of Merit of the Italian Republic
    2014, 2015 : Best Reviewer, Annals of Internal Medicine
    2014 : Best Fellow-in-Training Abstract Award, American College of Cardiology Scientific Session,    Washington, DC
    2013 : Early-Career Best Poster Award, American Heart Association Scientific Session, Dallas
    2012 : Best Paper Award, European Cardiac Arrhythmia Society Congress, Munich
               Best Paper Award, World Society of Arrhythmias Congress, Athens
    2011 : Best Oral Abstract Presentation Award, Best Poster Abstract Presentation Award, CardioRhythm    2011, Hong Kong
Research & Publications

Research & Publications

See publications for Pasquale Santangeli, MD, PhD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 9/25/2023, Dr. Santangeli has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Santangeli receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • Medical Device Business Services, Inc., formerly Depuy, Inc.
  • Boston Scientific Corporation
  • Abbott Laboratories

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

273 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 4.4
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

61 Patient Comments

Reviewed on Jun 24, 2024

Have already recommended provider to others.

Reviewed on Jun 10, 2024

I had an excellent evperiance with all my health providers at CC

Reviewed on Jun 5, 2024

I have a great deal of confidence in my physician's ability. The brevity of the consult made it difficult to develop rapport. The six to seven month wait time before my procedure was distressing.

Reviewed on May 20, 2024

The doctor was very friendly and down to earth.

Reviewed on May 8, 2024

Dr Santangeli is amazing!

Reviewed on Apr 29, 2024

Dr. Santangeli is the best !

Reviewed on Apr 29, 2024

Dr Santangeli was even more helpful and attuned to my situation than we had expected.

Reviewed on Apr 29, 2024

First time a doctor actually listened to me and looked at my information as a medical professional myself

Reviewed on Apr 29, 2024

Dr. Santangeli, is a great doctor that cares about his patients, He is a doctor that has a plan and knows what he wants to do, and also has a backup plan. His explanation of what procedure he too was very good and made me feel like I was relaxed and knowledgeable of my procedures.

Reviewed on Apr 29, 2024

I can't speak highly enough about my experiences at Cleveland clinic and Dr Santangeli and his staff. I rave about it to everyone who will listen and recommend Cleveland Clinic as tops in the field.

Reviewed on Apr 29, 2024

Dr Santangeli is a blessing. I am so thankful for the care he has provided me and forever grateful for all he has done to help me. Please let him know..

Reviewed on Apr 10, 2024

Excellent Dr is the best

Reviewed on Apr 10, 2024

Dr. Santangeli is a gem. I aired for him to do my procedure. He offered a partner sooner, but I had complete confidence in his ability. If one meets him, one wants to stay with him.

Reviewed on Apr 10, 2024

The wait times for medical care universally are not great. Dr. Santangeli is out 6 months. Not his or your fault. It is what it is.

Reviewed on Mar 27, 2024

The provider discerned the heart procedure I needed, quickly, perhaps in part based on the lengthy written comments I had provided on the office survey I filled out ahead of time. I had full confidence in him, from the initial meeting. My initially scheduled one hour visit was concluded in 15 minutes -- I wish he had explained more to me, in layman's terms, exactly what this type of surgery we'd agreed on would entail. I took a few notes and that's all I remember from the brief time I was with this provider. He is excellent. I have every confidence in his skill as a healer. I just feel "in the dark" about next steps.The provider told me that someone would call me from his scheduling office, within a week of my initial visit. I called today (7 days after first visit) and was told that calls back from this provider's office take 2 weeks. I hope he remembered to talk to his schedulers and relayed the same information to them that he told me.

Reviewed on Mar 25, 2024

What can I say , one of the most professional doctors I have ever dealt with. His concern and understanding of my health was outstanding and truly appreciated. I only wish more doctors were even somewhat on par with Dr Santangeli.

Reviewed on Mar 13, 2024

Dr Santangeli is an amazing person . He listened very patiently to everything I had to say. I was really nervous about my condition both time I visited him. But he always put me and my wife at ease. He answers all questions and sometimes even when I am not able tr explain myself properly, he still somehow knows everything and answers us very patiently . He is a great doctor and an amazing human being

Reviewed on Mar 13, 2024

Life changing. In a single visit Dr. Santangeli was able to diagnose and correct the problem with my pacemaker. I didn't even know that it was possible. It felt like the harness came off my heart. The relief was so great it was almost hard to believe. It was the best I have felt since the May 5th ablation in Colorado. I thank God I came to Cleveland and the wonderful care I have received. I feel hope again.

Reviewed on Mar 13, 2024

We have a much better understanding of my health and agree that if further procedures or surgery is needed we will come back. Also we will be using video/telemedicine for care.

Reviewed on Mar 13, 2024

Dr. Santangeli was outstanding, one of the best ever!

Reviewed on Feb 26, 2024

This comment doesn't reflect the care and advice of the doctors, when speaking to him over the phone he was very clear.

Reviewed on Feb 19, 2024

Absolutely an excellent, knowledgeable Dr! My heart problems addressed and referred for other issues. Dr Pasquale Santangeli is compassionate, extremely knowledgeable and an asset to The Cleveland Clinic.

Reviewed on Feb 12, 2024

Dr. SantanGeli was amazing. He explained everything very well, provided helpful information, he was not rushed (which was greatly appreciated), and seemed genuinely interested in making sure he answered all questions.

Reviewed on Jan 31, 2024

Very nice Doctor,,, well explained my problem,,, His staff was very nice, I was well pleased with me visit,

Reviewed on Jan 29, 2024

Dr. Santangeli explained everything in great detail and put both my wife and I at ease regarding the procedure.

Reviewed on Jan 3, 2024

I was so impressed with Dr. Santangeli. Very, very bright, great communicator, very thorough, carefully explained every aspect of the problem and possible treatments.Very easy to talk to

Reviewed on Dec 20, 2023

The provider is very kind, knowledgeable and helpful. He added the ZIO Monitor and personally placed the order to make sure that I would get it ASAP.

Reviewed on Dec 18, 2023

Dr. Santangeli was genuinely happy with my results. His supportive and positive demeanor validated my choice to come to Cleveland Clinic and the blessing that I was assigned Dr. Santangeli.

Reviewed on Dec 18, 2023

Everyone was way better than expected. Very impressed...especially with my doctor!

Reviewed on Dec 6, 2023

Staff is great, Amanda RN was awesome. Having nurses do vitals and assessing pts before MD is what sets apart from other Medical Centers. The value of a nurse assessing patients is well worth It. That is why outcomes are better when compared to other medical Centers. Access to system is like all health care these days scheduling 90 -120 days out seems outlandish.

Reviewed on Dec 4, 2023

Nurses and the doctor worked great with me getting it set-up quickly.

Reviewed on Dec 4, 2023

I'm so pleased with the care of my doctor and the attention that he provide to me about my conditions.

Reviewed on Dec 4, 2023

All staff and all my doctors are professional and care about my health.

Reviewed on Dec 4, 2023

So well organized for such a large and busy complex! All of the staff from registration staff, EKG tech, nurses and Physicians were so friendly and efficient!

Reviewed on Dec 4, 2023

Great Physician, friendly and easy to understand. Obviously an excellent Physician!

Reviewed on Nov 27, 2023

I was very impressed with the doctor and his manner to both my wife and myself.

Reviewed on Nov 27, 2023

I feel Dr. Santangeli could not have chosen a better endeavor for his personality. It is more than just a job to him, his natural compassion for human life is obvious. I feel so very blessed to have him as my heart doctor.

Reviewed on Nov 27, 2023

Dr. Santangeli cared about what mattered to me, explained approach to my condition with evidence and statistics.

Reviewed on Nov 27, 2023

I have complete confidence in my physician.

Reviewed on Nov 22, 2023

Dr. Santangelli has great bedside manner, he listened to all of my concerns and helped create an individual plan to fit my needs. I am very grateful to have been under his care.

Reviewed on Nov 20, 2023

Dr Sangangeli was everything I hoped for and more. He explained everything to me, my husband, and son and listened to all our questions and concerns!!!

Reviewed on Oct 30, 2023

Dr. Santangeli is not only brilliant, but very personable, and makes sure to give great explanations.

Reviewed on Oct 30, 2023

The doctor & all the staff at CC are kind, compassionate & professional!!

Reviewed on Oct 25, 2023

Dr Santangeli was exceptional. Very thankful and grateful to have been referred to him.

Reviewed on Oct 25, 2023

Dr Santangeli is an amazing physician!

Reviewed on Oct 16, 2023

Outstanding Dr. Traveled from Boston to Cleveland for this appt - glad to have done so.

Reviewed on Sep 27, 2023

Dr Santangeli was very caring and professional

Reviewed on Sep 18, 2023

Very good. The nurse was very competent during the intake. Dr Santangeli was very calming and thorough and reassuring.

Reviewed on Sep 18, 2023

Wonderful Dr with perfect patient rapport! Very courteous and knowledgeable.

Reviewed on Sep 18, 2023

Very good Doctor

Reviewed on Sep 13, 2023

Dr. Santangeli is outstanding

Reviewed on Aug 30, 2023

Dr. Santangeli was excellent in all phases of care.He is professional, confident, and kind.

Reviewed on Aug 30, 2023

Dr. Santangeli and his fellow were exhumed professionalism! He went out of his way to communicate to myself and wife.

Reviewed on Aug 30, 2023

I did have one concern. I was given light sedation. I overheard the anesthesiologist tell the CRNa that it was a general anesthetic.As a physician raised by an anesthesiologist I do question that. It may be an ethical issue??

Reviewed on Aug 28, 2023

Dr. Santangeli is just wonderful! He took his time and explained everything to me. He answered all my questions and concerns. This was a three month follow up visit for my surgery. It was so nice to have a doctor who really cares about how I am doing, how I feel and is supportive and understanding. I couldn't ask for a better doctor than Dr. Santangeli !

Reviewed on Aug 28, 2023

Dr. Is a wonderful person and fantastic Dr.I have recommended him to 2 of my family members.

Reviewed on Aug 21, 2023

Doctor was very friendly, very professional, spent time answering questions

Reviewed on Jul 19, 2023

Very impressed with everything and every provider I met; especially Dr Santatali.

Reviewed on Jul 11, 2023

During my stay, I was mostly under the direct care of my Doctor's PA. She was fantastic and very thorough.

Reviewed on Jul 11, 2023

*Dr. Santangeli was patient thorough and understanding.

Reviewed on Jul 5, 2023

*Dr. Shay Naklla & team in OR the best.

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