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Natalie Silver, MD

Natalie Silver, MD
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Title Director, Head and Neck Cancer Research
Department Head and Neck Institute
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon Yes
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Treatment & Services

  • Diagnostic Head and Neck
  • Flexible Fiberoptic Laryngoscopy
  • Flexible Fiberoptic Nasal Endoscopy
  • Head and Neck Cancer Surgery
  • Laryngoscopy
  • Neck Surgery
  • Parotidectomy
  • Tracheostomy
  • Voice and Larynx Surgery
View all 9 Treatment & Services +

Specialty in Diseases & Conditions

  • Cancer
  • Carcinoma of Unknown Primary
  • Carotid Body Tumor
  • Congenital Head and Neck Masses
  • Goiter
  • Head and Neck Cancer
  • Head and Neck Masses
  • Head and Neck Paragangliomas
  • Head and Neck Tumors
  • Hypopharyngeal Cancer
  • Laryngeal Cancer
  • Lip and Oral Cavity Cancer
  • Melanoma
  • Mouth Lesions
  • Nasopharyngeal Cancer
  • Oropharyngeal Cancer
  • Parathyroid Cancer
  • Parathyroid Disease
  • Parotid Tumors
  • Pediatric Salivary Gland Tumors
  • Pediatric Thyroid Cancer
  • Pediatric Thyroid Masses
  • Pediatric Tumors
  • Salivary Gland Diseases
  • Skin Cancer
  • Soft Tissue Sarcoma
  • Thyroid Cancer
  • Thyroid Disease
  • Thyroid Nodule
View all 29 Specialties +


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About Natalie Silver, MD

Natalie Silver MD, MS, FACS, is Staff at the Cleveland Clinic Head & Neck Institute and serves as the Director of Head and Neck Cancer Research. Dr. Silver is a surgeon-scientist with a translational research lab studying oral cancer in the Center of Immunotherapy and Precision Immuno-Oncology in the Cleveland Clinic Lerner Research Institute.

Dr. Silver obtained her medical degree from Georgetown University College of Medicine in Washington, DC. She also received her Master's Degree in Tumor Biology from the Georgetown University Graduate School of Arts and Sciences. She completed her Otolaryngology-Head and Neck surgery residency at the University of Kentucky. She then went to UT MD Anderson Cancer Center, in Houston Texas, for advanced training in head and neck cancer and completed both a research and clinical fellowship. She spent one year as a research fellow conducting basic science research and her clinical year was spent learning advanced surgical techniques for head and neck cancer. While faculty at the University of Florida, Dr. Silver served as the UF Health Cancer Center Head and Neck Cancer Disease Site Group Research Leader for six years and was site-Prinicpal Investigator (PI) for many head and neck cancer clinical trials.

Dr. Silver is a member of the American Board of Orolaryngology, American Head and Neck Society, American College of Surgeons, the Society for Immunotherapy for Cancer, and the American Association for Cancer Research. She has received several research grants (including a National Institutes of Health (NIH K08 award) and has published multiple research articles in peer-reviewed journals, as well as having contributed abstracts and presentations at a number of professional association meetings. Her lab research focus is on developing therapeutic mRNA nano-vaccines for head and neck cancer, and exploring the role of the microbiome in oral cancer.

Dr. Silver is an active head and neck surgical oncologist specializing in ablative head and neck cancer surgery and endocrine surgery. Her goal is to provide the best surgical care for her patients in a multi-disciplinary setting, ensuring that the patient is offered the best, most advanced, individualized care. In additional to providing excellent surgical care, Dr. Silver is working toward building a better future for her patients by studying cancer in the laboratory and translating these discoveries to the clinic.

Listen to Dr. Silver on our Head and Neck Innovations podcast: The Latest on Oral Cancer Clinical Trials

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - University of Texas- Anderson Cancer Center
Surgical Oncology
Houston, TX

Residency - University of Kentucky College of Medicine
Otolaryngology - Head and Neck Surgery
Lexington, KY

Medical Education - Georgetown Univ. School of Medicine
Washington, DC

Graduate School - Georgetown Univeristy Graduate School of Arts and Sciences



  • Otolaryngology - Head and Neck Surgery
Research & Publications

Research & Publications

See publications for Natalie Silver, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 4/5/2024, Dr. Silver has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

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